UTNet: A Hybrid Transformer Architecture for Medical Image Segmentation
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Abstract (arXiv)
Transformer architecture has emerged to be successful in a number of natural language processing tasks. However, its applications to medical vision remain largely unexplored. In this study, we present UTNet, a simple yet powerful hybrid Transformer architecture that integrates self-attention into a convolutional neural network for enhancing medical image segmentation. UTNet applies self-attention modules in both encoder and decoder for capturing long-range dependency at different scales with minimal overhead. To this end, we propose an efficient self-attention mechanism along with relative position encoding that reduces the complexity of self-attention operation significantly from O(n2) to approximate O(n). A new self-attention decoder is also proposed to recover fine-grained details from the skipped connections in the encoder. Our approach addresses the dilemma that Transformer requires huge amounts of data to learn vision inductive bias. Our hybrid layer design allows the initialization of Transformer into convolutional networks without a need of pre-training. We have evaluated UTNet on the multi-label, multi-vendor cardiac magnetic resonance imaging cohort. UTNet demonstrates superior segmentation performance and robustness against the state-of-the-art approaches, holding the promise to generalize well on other medical image segmentations.
Key facts. Cited by 116 papers in the map (data through 7 Oct 2026). Builds on 23 of its 31 references that are in the map. First posted on arXiv 2 Jul 2021.
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23 of 31 references.
References · 23
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11 more
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Citing papers per year: 2021: 3; 2022: 32; 2023: 28; 2024: 30; 2025: 15; 2026: 8.
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- 2022Transformers in Medical Imaging: A Surveycited by 245
- 2024nnU-Net Revisited: A Call for Rigorous Validation in 3D Medical Image Segmentationcited by 235
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- 2023MIS-FM: 3D Medical Image Segmentation using Foundation Models Pretrained on a Large-Scale Unannotated Datasetcited by 25
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- 2024Semi-Mamba-UNet: Pixel-Level Contrastive and Pixel-Level Cross-Supervised Visual Mamba-based UNet for Semi-Supervised Medical Image Segmentationcited by 20
- 2022Multimodal Multi-Head Convolutional Attention with Various Kernel Sizes for Medical Image Super-Resolutioncited by 17
- 2022DeepRecon: Joint 2D Cardiac Segmentation and 3D Volume Reconstruction via A Structure-Specific Generative Methodcited by 17
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- 2021CyTran: A Cycle-Consistent Transformer with Multi-Level Consistency for Non-Contrast to Contrast CT Translationcited by 15
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- 2023Boundary Difference Over Union Loss For Medical Image Segmentationcited by 13
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- 2024Clustering Propagation for Universal Medical Image Segmentationcited by 11
- 2022Toward Unpaired Multi-modal Medical Image Segmentation via Learning Structured Semantic Consistencycited by 10
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- 2025MSLAU-Net: A Hybrid CNN-Transformer Network for Medical Image Segmentation24 May 2025
- 2025The Application of Deep Learning for Lymph Node Segmentation: A Systematic Review9 May 2025
- 2025DFEN: Dual Feature Equalization Network for Medical Image Segmentation9 May 2025
- 2025Med-2D SegNet: A Light Weight Deep Neural Network for Medical 2D Image Segmentation20 Apr 2025
- 2025Primus: Enforcing Attention Usage for 3D Medical Image Segmentation3 Mar 2025
- 2025TransGUNet: Transformer Meets Graph-based Skip Connection for Medical Image Segmentation14 Feb 2025
- 2025Merging Context Clustering with Visual State Space Models for Medical Image Segmentation3 Jan 2025
- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation11 Dec 2024
- 2024HYATT-Net is Grand: A Hybrid Attention Network for Performant Anatomical Landmark Detection9 Dec 2024
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- 2024Continuous Spatio-Temporal Memory Networks for 4D Cardiac Cine MRI Segmentation30 Oct 2024
- 2024Compositional Segmentation of Cardiac Images Leveraging Metadata30 Oct 2024
- 2024SFB-net for cardiac segmentation: Bridging the semantic gap with attention24 Oct 2024
- 2024D2-MLP: Dynamic Decomposed MLP Mixer for Medical Image Segmentation13 Sep 2024
- 2024TBConvL-Net: A Hybrid Deep Learning Architecture for Robust Medical Image Segmentation5 Sep 2024
- 2024MedSAM-U: Uncertainty-Guided Auto Multi-Prompt Adaptation for Reliable MedSAM2 Sep 2024
- 2024FedGS: Federated Gradient Scaling for Heterogeneous Medical Image Segmentation21 Aug 2024
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- 2024RaffeSDG: Random Frequency Filtering enabled Single-source Domain Generalization for Medical Image Segmentation2 May 2024
- 2024GLIMS: Attention-Guided Lightweight Multi-Scale Hybrid Network for Volumetric Semantic Segmentation27 Apr 2024
- 2024Multi-view Cardiac Image Segmentation via Trans-Dimensional Priors25 Apr 2024
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- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentationcited by 7
- 2024CAMS: Convolution and Attention-Free Mamba-based Cardiac Image Segmentationcited by 4
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- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation11 Dec 2024
- 2024CAMS: Convolution and Attention-Free Mamba-based Cardiac Image Segmentation9 Jun 2024
- 2024Semi-Mamba-UNet: Pixel-Level Contrastive and Pixel-Level Cross-Supervised Visual Mamba-based UNet for Semi-Supervised Medical Image Segmentation11 Feb 2024
- 2022Transformers in Medical Imaging: A Surveycited by 245
- 2024nnU-Net Revisited: A Call for Rigorous Validation in 3D Medical Image Segmentationcited by 235
- 2021UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformercited by 197
- 2022MALUNet: A Multi-Attention and Light-weight UNet for Skin Lesion Segmentationcited by 59
- 2022A Data-scalable Transformer for Medical Image Segmentation: Architecture, Model Efficiency, and Benchmarkcited by 45
- 2022Transformers in Medical Image Analysis: A Reviewcited by 41
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
- 2023Training Like a Medical Resident: Context-Prior Learning Toward Universal Medical Image Segmentationcited by 32
- 2021iSegFormer: Interactive Segmentation via Transformers with Application to 3D Knee MR Imagescited by 27
- 2024Data-Centric Foundation Models in Computational Healthcare: A Surveycited by 27
- 2022Surface Vision Transformers: Attention-Based Modelling applied to Cortical Analysiscited by 25
- 2023MIS-FM: 3D Medical Image Segmentation using Foundation Models Pretrained on a Large-Scale Unannotated Datasetcited by 25
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- 2026ASGNet: Adaptive Spectrum Guidance Network for Automatic Polyp Segmentation16 Apr 2026
- 2026BiSe-Unet: A Lightweight Dual-path U-Net with Attention-refined Context for Real-time Medical Image Segmentation22 Feb 2026
- 2026VariViT: A Vision Transformer for Variable Image Sizes16 Feb 2026
- 2026HUR-MACL: High-Uncertainty Region-Guided Multi-Architecture Collaborative Learning for Head and Neck Multi-Organ Segmentation8 Jan 2026
- 2025Atlas is Your Perfect Context: One-Shot Customization for Generalizable Foundational Medical Image Segmentation20 Dec 2025
- 2025Bridging spatial awareness and global context in medical image segmentation6 Dec 2025
- 2025Focal Modulation and Bidirectional Feature Fusion Network for Medical Image Segmentation23 Oct 2025
- 2025BrainPuzzle: Hybrid Physics and Data-Driven Reconstruction for Transcranial Ultrasound Tomography22 Oct 2025
- 2025Rethinking Convergence in Deep Learning: The Predictive-Corrective Paradigm for Anatomy-Informed Brain MRI Segmentation17 Oct 2025
- 2025MedDINOv3: How to adapt vision foundation models for medical image segmentation?2 Sep 2025
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