Multi-Compound Transformer for Accurate Biomedical Image Segmentation
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Abstract (arXiv)
The recent vision transformer(i.e.for image classification) learns non-local attentive interaction of different patch tokens. However, prior arts miss learning the cross-scale dependencies of different pixels, the semantic correspondence of different labels, and the consistency of the feature representations and semantic embeddings, which are critical for biomedical segmentation. In this paper, we tackle the above issues by proposing a unified transformer network, termed Multi-Compound Transformer (MCTrans), which incorporates rich feature learning and semantic structure mining into a unified framework. Specifically, MCTrans embeds the multi-scale convolutional features as a sequence of tokens and performs intra- and inter-scale self-attention, rather than single-scale attention in previous works. In addition, a learnable proxy embedding is also introduced to model semantic relationship and feature enhancement by using self-attention and cross-attention, respectively. MCTrans can be easily plugged into a UNet-like network and attains a significant improvement over the state-of-the-art methods in biomedical image segmentation in six standard benchmarks. For example, MCTrans outperforms UNet by 3.64%, 3.71%, 4.34%, 2.8%, 1.88%, 1.57% in Pannuke, CVC-Clinic, CVC-Colon, Etis, Kavirs, ISIC2018 dataset, respectively. Code is available at https://github.com/JiYuanFeng/MCTrans.
Key facts. Cited by 42 papers in the map (data through 7 Oct 2026). Builds on 19 of its 26 references that are in the map. First posted on arXiv 28 Jun 2021.
Builds on
19 of 26 references.
References · 19
- 2017Attention Is All You Needcited by 59,932
- 2015Deep Residual Learning for Image Recognitioncited by 51,809
- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 29,915
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
- 2014Very Deep Convolutional Networks for Large-Scale Image Recognitioncited by 15,267
- 2020End-to-End Object Detection with Transformerscited by 7,384
- 2014Fully Convolutional Networks for Semantic Segmentationcited by 4,845
- 2020Deformable DETR: Deformable Transformers for End-to-End Object Detectioncited by 3,410
- 2016DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFscited by 3,239
- 2016Pyramid Scene Parsing Networkcited by 2,472
- 2017Non-local Neural Networkscited by 2,290
- 2021TransUNet: Transformers Make Strong Encoders for Medical Image Segmentationcited by 1,552
7 more
- 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,518
- 2018Attention U-Net: Learning Where to Look for the Pancreascited by 1,420
- 2019Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)cited by 657
- 2019CE-Net: Context Encoder Network for 2D Medical Image Segmentationcited by 219
- 2020Context Prior for Scene Segmentationcited by 121
- 2021Segmenting Transparent Object in the Wild with Transformercited by 13
- 2020UXNet: Searching Multi-level Feature Aggregation for 3D Medical Image Segmentationcited by 11
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Citing papers per year: 2021: 2; 2022: 11; 2023: 13; 2024: 8; 2025: 3; 2026: 5.
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- 2022Transformers in Medical Imaging: A Surveycited by 245
- 2021UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformercited by 197
- 2021TransAttUnet: Multi-level Attention-guided U-Net with Transformer for Medical Image Segmentationcited by 60
- 2022Transformers in Medical Image Analysis: A Reviewcited by 41
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
- 2023ACC-UNet: A Completely Convolutional UNet model for the 2020scited by 26
- 2022A Survey on Deep Learning for Skin Lesion Segmentationcited by 22
- 2022TransFusion: Multi-view Divergent Fusion for Medical Image Segmentation with Transformerscited by 21
- 2023Transformers in Healthcare: A Surveycited by 17
- 2024LaB-GATr: geometric algebra transformers for large biomedical surface and volume meshescited by 12
- 2022Do we really need temporal convolutions in action segmentation?cited by 10
- 2022The Lighter The Better: Rethinking Transformers in Medical Image Segmentation Through Adaptive Pruningcited by 9
30 more
- 2023Attention Mechanisms in Medical Image Segmentation: A Surveycited by 9
- 2023Narrowing the semantic gaps in U-Net with learnable skip connections: The case of medical image segmentationcited by 9
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- 2023The Multiscale Surface Vision Transformercited by 6
- 2023Revisiting Computer-Aided Tuberculosis Diagnosiscited by 6
- 2022Toward Clinically Assisted Colorectal Polyp Recognition via Structured Cross-modal Representation Consistencycited by 5
- 2023MCANet: Medical Image Segmentation with Multi-Scale Cross-Axis Attentioncited by 5
- 2024HResFormer: Hybrid Residual Transformer for Volumetric Medical Image Segmentationcited by 4
- 2022ConvTransSeg: A Multi-resolution Convolution-Transformer Network for Medical Image Segmentationcited by 3
- 2023TranSOP: Transformer-based Multimodal Classification for Stroke Treatment Outcome Predictioncited by 3
- 2023HST-MRF: Heterogeneous Swin Transformer with Multi-Receptive Field for Medical Image Segmentationcited by 3
- 2024Crop and Couple: cardiac image segmentation using interlinked specialist networkscited by 2
- 2024SkinFormer: Learning Statistical Texture Representation with Transformer for Skin Lesion Segmentationcited by 2
- 2026Debunking Grad-ECLIP: A Comprehensive Study on Its Incorrectness and Fundamental Principles for Model Interpretationcited by 2
- 2022Memory-efficient Segmentation of High-resolution Volumetric MicroCT Imagescited by 1
- 2023A New Perspective to Boost Vision Transformer for Medical Image Classificationcited by 1
- 2023LCAUnet: A skin lesion segmentation network with enhanced edge and body fusioncited by 1
- 2024Q2A: Querying Implicit Fully Continuous Feature Pyramid to Align Features for Medical Image Segmentationcited by 1
- 2024Compositional Segmentation of Cardiac Images Leveraging Metadatacited by 1
- 2025Multi-label Classification with Panoptic Context Aggregation Networkscited by 1
- 2022WSC-Trans: A 3D network model for automatic multi-structural segmentation of temporal bone CTcited by 0
- 2023Switched auxiliary loss for robust training of transformer models for histopathological image segmentationcited by 0
- 2024Multi-view Cardiac Image Segmentation via Trans-Dimensional Priorscited by 0
- 2024Automatic diagnosis of cardiac magnetic resonance images based on semi-supervised learningcited by 0
- 2025MACMD: Multi-dilated Contextual Attention and Channel Mixer Decoding for Medical Image Segmentationcited by 0
- 2025TCLeaf-Net: a transformer-convolution framework with global-local attention for robust in-field lesion-level plant leaf disease detectioncited by 0
- 2026ProGiDiff: Prompt-Guided Diffusion-Based Medical Image Segmentationcited by 0
- 2026Transformer Interpretability from Perspective of Attention and Gradientcited by 0
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigmscited by 0
- 2026Unraveling the Real Working Mechanism and Inherent Flaws of GAE: A Method for Interpreting Transformer Processes from an Economic Perspectivecited by 0
- 2026Unraveling the Real Working Mechanism and Inherent Flaws of GAE: A Method for Interpreting Transformer Processes from an Economic Perspective7 Sep 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026Debunking Grad-ECLIP: A Comprehensive Study on Its Incorrectness and Fundamental Principles for Model Interpretation13 May 2026
- 2026Transformer Interpretability from Perspective of Attention and Gradient12 May 2026
- 2026ProGiDiff: Prompt-Guided Diffusion-Based Medical Image Segmentation22 Jan 2026
- 2025Multi-label Classification with Panoptic Context Aggregation Networks29 Dec 2025
- 2025TCLeaf-Net: a transformer-convolution framework with global-local attention for robust in-field lesion-level plant leaf disease detection13 Dec 2025
- 2025MACMD: Multi-dilated Contextual Attention and Channel Mixer Decoding for Medical Image Segmentation8 Nov 2025
- 2024HResFormer: Hybrid Residual Transformer for Volumetric Medical Image Segmentation16 Dec 2024
- 2024Compositional Segmentation of Cardiac Images Leveraging Metadata30 Oct 2024
- 2024SkinFormer: Learning Statistical Texture Representation with Transformer for Skin Lesion Segmentation13 Sep 2024
- 2024Automatic diagnosis of cardiac magnetic resonance images based on semi-supervised learning23 May 2024
30 more
- 2024Multi-view Cardiac Image Segmentation via Trans-Dimensional Priors25 Apr 2024
- 2024Q2A: Querying Implicit Fully Continuous Feature Pyramid to Align Features for Medical Image Segmentation15 Apr 2024
- 2024LaB-GATr: geometric algebra transformers for large biomedical surface and volume meshes12 Mar 2024
- 2024Crop and Couple: cardiac image segmentation using interlinked specialist networks14 Feb 2024
- 2023Narrowing the semantic gaps in U-Net with learnable skip connections: The case of medical image segmentation23 Dec 2023
- 2023MCANet: Medical Image Segmentation with Multi-Scale Cross-Axis Attention14 Dec 2023
- 2023ACC-UNet: A Completely Convolutional UNet model for the 2020s25 Aug 2023
- 2023Switched auxiliary loss for robust training of transformer models for histopathological image segmentation21 Aug 2023
- 2023Revisiting Computer-Aided Tuberculosis Diagnosis6 Jul 2023
- 2023Transformers in Healthcare: A Survey30 Jun 2023
- 2023Attention Mechanisms in Medical Image Segmentation: A Survey29 May 2023
- 2023MaxViT-UNet: Multi-Axis Attention for Medical Image Segmentation15 May 2023
- 2023LCAUnet: A skin lesion segmentation network with enhanced edge and body fusion1 May 2023
- 2023HST-MRF: Heterogeneous Swin Transformer with Multi-Receptive Field for Medical Image Segmentation10 Apr 2023
- 2023The Multiscale Surface Vision Transformer21 Mar 2023
- 2023TranSOP: Transformer-based Multimodal Classification for Stroke Treatment Outcome Prediction25 Jan 2023
- 2023A New Perspective to Boost Vision Transformer for Medical Image Classification3 Jan 2023
- 2022WSC-Trans: A 3D network model for automatic multi-structural segmentation of temporal bone CT14 Nov 2022
- 2022ConvTransSeg: A Multi-resolution Convolution-Transformer Network for Medical Image Segmentation13 Oct 2022
- 2022The Lighter The Better: Rethinking Transformers in Medical Image Segmentation Through Adaptive Pruning29 Jun 2022
- 2022Toward Clinically Assisted Colorectal Polyp Recognition via Structured Cross-modal Representation Consistency23 Jun 2022
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectives2 Jun 2022
- 2022A Survey on Deep Learning for Skin Lesion Segmentation1 Jun 2022
- 2022Memory-efficient Segmentation of High-resolution Volumetric MicroCT Images31 May 2022
- 2022Do we really need temporal convolutions in action segmentation?26 May 2022
- 2022TransFusion: Multi-view Divergent Fusion for Medical Image Segmentation with Transformers21 Mar 2022
- 2022Transformers in Medical Image Analysis: A Review24 Feb 2022
- 2022Transformers in Medical Imaging: A Survey24 Jan 2022
- 2021UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformer9 Sep 2021
- 2021TransAttUnet: Multi-level Attention-guided U-Net with Transformer for Medical Image Segmentation12 Jul 2021
- 2022Transformers in Medical Imaging: A Surveycited by 245
- 2021UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformercited by 197
- 2021TransAttUnet: Multi-level Attention-guided U-Net with Transformer for Medical Image Segmentationcited by 60
- 2022Transformers in Medical Image Analysis: A Reviewcited by 41
- 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
- 2023ACC-UNet: A Completely Convolutional UNet model for the 2020scited by 26
- 2022A Survey on Deep Learning for Skin Lesion Segmentationcited by 22
- 2022TransFusion: Multi-view Divergent Fusion for Medical Image Segmentation with Transformerscited by 21
- 2023Transformers in Healthcare: A Surveycited by 17
- 2024LaB-GATr: geometric algebra transformers for large biomedical surface and volume meshescited by 12
- 2022Do we really need temporal convolutions in action segmentation?cited by 10
- 2022The Lighter The Better: Rethinking Transformers in Medical Image Segmentation Through Adaptive Pruningcited by 9
12 most cited of 41 All 41 (JSON)
- 2026Unraveling the Real Working Mechanism and Inherent Flaws of GAE: A Method for Interpreting Transformer Processes from an Economic Perspective7 Sep 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026Debunking Grad-ECLIP: A Comprehensive Study on Its Incorrectness and Fundamental Principles for Model Interpretation13 May 2026
- 2026Transformer Interpretability from Perspective of Attention and Gradient12 May 2026
- 2025Multi-label Classification with Panoptic Context Aggregation Networks29 Dec 2025
- 2025TCLeaf-Net: a transformer-convolution framework with global-local attention for robust in-field lesion-level plant leaf disease detection13 Dec 2025
- 2025MACMD: Multi-dilated Contextual Attention and Channel Mixer Decoding for Medical Image Segmentation8 Nov 2025
- 2024HResFormer: Hybrid Residual Transformer for Volumetric Medical Image Segmentation16 Dec 2024
- 2024Compositional Segmentation of Cardiac Images Leveraging Metadata30 Oct 2024
- 2024SkinFormer: Learning Statistical Texture Representation with Transformer for Skin Lesion Segmentation13 Sep 2024
- 2024Automatic diagnosis of cardiac magnetic resonance images based on semi-supervised learning23 May 2024
- 2024Multi-view Cardiac Image Segmentation via Trans-Dimensional Priors25 Apr 2024
12 newest of 41 All 41 (JSON)