ChemArgus: Automated Scientific Diagnostics for Lab-Grade Multimodal Chemistry Reasoning: A Frontier Benchmark
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Chemistry evaluation has moved past multiple-choice probes toward open-ended expert problems, yet the benchmarks that define the current frontier still score answer endpoints alone. Such scoring conflates memorized facts with stepwise derivation, treats visual and textual inputs as interchangeable, and confounds long-horizon planning with stepwise execution. These blind spots prevent any diagnosis of where the reasoning chain breaks in a model. We present ChemArgus, a competition-level chemistry benchmark drawn from chemistry competition material, textbooks, and research papers, whose scoring replaces the answer endpoint with three measurement properties. Fine-grained scoring grades every subquestion point by point with partial credit, so a score lands at the level of the step rather than the outcome. Multimodal capability is priced on every problem containing a real image, paired with a controlled text description, so visual understanding is measured against text on identical tasks. Diagnostic attribution reads paired metrics that share one scoring unit and differ only in context construction, so a gap between two scores isolates a single cause, namely integration, propagation, or local reasoning. GPT-5.6-Sol scores 23.2% on unassisted whole-problem solving against 28.8% and 30.4% under the two sequential metrics, a gap measuring the integration burden. Through rubric partial credit and these cause-isolating score gaps, ChemArgus shows not only whether a model answers chemistry correctly but where its reasoning chain fails, so that every score it reports doubles as a diagnosis, a readout of the chain rather than a verdict, aiming to guide language models step by step on their path toward chemistry expertise, one corrected step at a time, each step priced by the rubric, point by point.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 60 of its 68 references that are in the map. First posted on arXiv 14 Oct 2026.
Builds on
60 of 68 references.
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- 2025SUPERChem: A Multimodal Reasoning Benchmark in Chemistry1 Dec
- 2025Assessing the Chemical Intelligence of Large Language Models12 May
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