Reimagining Urban Science: Scaling Causal Inference with Large Language Models

Urban causal research is essential for understanding the complex, dynamic processes that shape cities and for informing evidence-based policies. However, current practices are often constrained by inefficient and biased hypothesis formulation, challenges in integrating multimodal data, and fragile experimental methodologies. Imagine a system that automatically estimates the causal impact of congestion pricing on commute times by income group or measures how new green spaces affect asthma rates across neighborhoods using satellite imagery and health reports, and then generates comprehensive, policy-ready outputs, including causal estimates, subgroup analyses, and actionable recommendations. In this Perspective, we propose UrbanCIA, an LLM-driven conceptual framework composed of four distinct modular agents responsible for hypothesis generation, data engineering, experiment design and execution, and results interpretation with policy insights. We begin by examining the current landscape of urban causal research through a structured taxonomy of research topics, data sources, and methodological approaches, revealing systemic limitations across the workflow. Next, we introduce the design principles and technological roadmap for the four modules in the proposed framework. We also propose evaluation criteria to assess the rigor and transparency of these AI-augmented processes. Finally, we reflect on the broader implications for human-AI collaboration, equity, and accountability. We call for a new research agenda that embraces LLM-driven tools as catalysts for more scalable, reproducible, and inclusive urban research.