Deep Generative Models for 3D Medical Image Synthesis
Not on the map. Why?
Abstract (arXiv)
Deep generative modeling has emerged as a powerful tool for synthesizing realistic medical images, driving advances in medical image analysis, disease diagnosis, and treatment planning. This chapter explores various deep generative models for 3D medical image synthesis, with a focus on Variational Autoencoders (VAEs), Generative Adversarial Networks (GANs), and Denoising Diffusion Models (DDMs). We discuss the fundamental principles, recent advances, as well as strengths and weaknesses of these models and examine their applications in clinically relevant problems, including unconditional and conditional generation tasks like image-to-image translation and image reconstruction. We additionally review commonly used evaluation metrics for assessing image fidelity, diversity, utility, and privacy and provide an overview of current challenges in the field.
Key facts. Cited by 14 papers in the map (data through 14 Oct 2026). Builds on 89 of its 140 references that are in the map. First posted on arXiv 23 Oct 2024.
Builds on
89 of 140 references.
References · 89
- 2017Attention Is All You Needcited by 60,361
- 2020Denoising Diffusion Probabilistic Modelscited by 21,076
- 2021High-Resolution Image Synthesis with Latent Diffusion Modelscited by 18,863
- 2018The Unreasonable Effectiveness of Deep Features as a Perceptual Metriccited by 11,177
- 2020Denoising Diffusion Implicit Modelscited by 9,781
- 2021Diffusion Models Beat GANs on Image Synthesiscited by 8,255
- 2015Deep Unsupervised Learning using Nonequilibrium Thermodynamicscited by 7,058
- 2017Neural Discrete Representation Learningcited by 4,712
- 2019Analyzing and Improving the Image Quality of StyleGANcited by 3,588
- 2017Quo Vadis, Action Recognition? A New Model and the Kinetics Datasetcited by 3,270
- 2020Taming Transformers for High-Resolution Image Synthesiscited by 3,253
- 2016Improved Techniques for Training GANscited by 2,970
38 more
- 2018Large Scale GAN Training for High Fidelity Natural Image Synthesiscited by 2,626
- 2017Improved Training of Wasserstein GANscited by 2,235
- 2015Variational Inference with Normalizing Flowscited by 2,170
- 2023Consistency Modelscited by 1,822
- 2016WaveNet: A Generative Model for Raw Audiocited by 1,722
- 2018Spectral Normalization for Generative Adversarial Networkscited by 1,636
- 2015LSUN: Construction of a Large-scale Image Dataset using Deep Learning with Humans in the Loopcited by 1,355
- 2018Demystifying MMD GANscited by 1,293
- 2016Least Squares Generative Adversarial Networkscited by 1,001
- 2019Improved Precision and Recall Metric for Assessing Generative Modelscited by 944
- 2021Diffusion Probabilistic Models for 3D Point Cloud Generationcited by 735
- 2023Extracting Training Data from Diffusion Modelscited by 732
- 2023Erasing Concepts from Diffusion Modelscited by 539
- 2021Tackling the Generative Learning Trilemma with Denoising Diffusion GANscited by 516
- 2018Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challengecited by 511
- 2018Assessing Generative Models via Precision and Recallcited by 406
- 2019Med3D: Transfer Learning for 3D Medical Image Analysiscited by 288
- 2022Brain Imaging Generation with Latent Diffusion Modelscited by 268
- 2018GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classificationcited by 242
- 2022Diffusion Models for Medical Anomaly Detectioncited by 232
- 2018A Note on the Inception Scorecited by 226
- 2021Diffusion Models for Implicit Image Segmentation Ensemblescited by 198
- 2022MedSegDiff: Medical Image Segmentation with Diffusion Probabilistic Modelcited by 180
- 2019Effectively Unbiased FID and Inception Score and where to find themcited by 165
- 2022Solving 3D Inverse Problems using Pre-trained 2D Diffusion Modelscited by 132
- 2023On Memorization in Diffusion Modelscited by 125
- 2022Wavelet Diffusion Models are fast and scalable Image Generatorscited by 117
- 2023Generative models improve fairness of medical classifiers under distribution shiftscited by 90
- 2023Conditional Diffusion Models for Semantic 3D Brain MRI Synthesiscited by 86
- 2024Anatomically-Controllable Medical Image Generation with Segmentation-Guided Diffusion Modelscited by 69
- 2019Generation of 3D Brain MRI Using Auto-Encoding Generative Adversarial Networkscited by 65
- 2023Adaptive Latent Diffusion Model for 3D Medical Image to Image Translation: Multi-modal Magnetic Resonance Imaging Studycited by 64
- 2020Hierarchical Amortized Training for Memory-efficient High Resolution 3D GANcited by 60
- 2021On Memorization in Probabilistic Deep Generative Modelscited by 60
- 2022Will Large-scale Generative Models Corrupt Future Datasets?cited by 59
- 2021DiffuseMorph: Unsupervised Deformable Image Registration Using Diffusion Modelcited by 58
- 2022SADM: Sequence-Aware Diffusion Model for Longitudinal Medical Image Generationcited by 56
- 2023Improving 3D Imaging with Pre-Trained Perpendicular 2D Diffusion Modelscited by 53
50 most cited of 89 All 89 (JSON)
Built on by
Citing papers per year: 2024: 4; 2025: 5; 2026: 5.
14 papers.
Sort:
By area:
- 20243D MedDiffusion: A 3D Medical Latent Diffusion Model for Controllable and High-quality Medical Image Generationcited by 37
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesiscited by 19
- 2024vesselFM: A Foundation Model for Universal 3D Blood Vessel Segmentationcited by 18
- 2024Denoising Diffusion Models for Anomaly Localization in Medical Imagescited by 3
- 2026EchoLVFM: One-Step Video Generation via Latent Flow Matching for Echocardiogram Synthesiscited by 3
- 2025Evaluation of 3D Counterfactual Brain MRI Generationcited by 2
- 2026Treatment-Conditioned Diffusion for Forecasting Neurodegenerative Disease Progressioncited by 1
- 2026Tractography-Driven Synthetic Data Generation for Fiber Bundle Segmentation in Tracer Histologycited by 1
- 2026Knowledge-Guided 3D CT Generation: A Conditioning-Centric Taxonomycited by 1
- 2025Efficient and robust 3D blind harmonization for large domain gapscited by 0
- 2025MInDI-3D: Iterative Deep Learning in 3D for Sparse-view Cone Beam Computed Tomographycited by 0
- 2025Towards Diagnostic Quality Flat-Panel Detector CT Imaging Using Diffusion Modelscited by 0
- 2026Knowledge-Guided 3D CT Generation: A Conditioning-Centric Taxonomy7 Aug 2026
- 2026Tractography-Driven Synthetic Data Generation for Fiber Bundle Segmentation in Tracer Histology25 Jun 2026
- 2026Structural MRI Synthesis for Alzheimer's Disease via Conditional Diffusion on Anatomical Masks16 Jun 2026
- 2026Treatment-Conditioned Diffusion for Forecasting Neurodegenerative Disease Progression28 May 2026
- 2026EchoLVFM: One-Step Video Generation via Latent Flow Matching for Echocardiogram Synthesis14 Mar 2026
- 2025Deep Generative Models for Enhanced Vitreous OCT Imaging2 Nov 2025
- 2025Towards Diagnostic Quality Flat-Panel Detector CT Imaging Using Diffusion Models22 Aug 2025
- 2025MInDI-3D: Iterative Deep Learning in 3D for Sparse-view Cone Beam Computed Tomography13 Aug 2025
- 2025Evaluation of 3D Counterfactual Brain MRI Generation4 Aug 2025
- 2025Efficient and robust 3D blind harmonization for large domain gaps30 Apr 2025
- 20243D MedDiffusion: A 3D Medical Latent Diffusion Model for Controllable and High-quality Medical Image Generation17 Dec 2024
- 2024vesselFM: A Foundation Model for Universal 3D Blood Vessel Segmentation26 Nov 2024
- 20243D MedDiffusion: A 3D Medical Latent Diffusion Model for Controllable and High-quality Medical Image Generationcited by 37
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesiscited by 19
- 2024Denoising Diffusion Models for Anomaly Localization in Medical Imagescited by 3
- 2026EchoLVFM: One-Step Video Generation via Latent Flow Matching for Echocardiogram Synthesiscited by 3
- 2025Deep Generative Models for Enhanced Vitreous OCT Imagingcited by 0
- 2026Structural MRI Synthesis for Alzheimer's Disease via Conditional Diffusion on Anatomical Maskscited by 0
- 2026Structural MRI Synthesis for Alzheimer's Disease via Conditional Diffusion on Anatomical Masks16 Jun 2026
- 2026EchoLVFM: One-Step Video Generation via Latent Flow Matching for Echocardiogram Synthesis14 Mar 2026
- 2025Deep Generative Models for Enhanced Vitreous OCT Imaging2 Nov 2025
- 20243D MedDiffusion: A 3D Medical Latent Diffusion Model for Controllable and High-quality Medical Image Generation17 Dec 2024
- 2024cWDM: Conditional Wavelet Diffusion Models for Cross-Modality 3D Medical Image Synthesis26 Nov 2024
- 2024Denoising Diffusion Models for Anomaly Localization in Medical Images31 Oct 2024
- 2024vesselFM: A Foundation Model for Universal 3D Blood Vessel Segmentationcited by 18
- 2025Evaluation of 3D Counterfactual Brain MRI Generationcited by 2
- 2026Treatment-Conditioned Diffusion for Forecasting Neurodegenerative Disease Progressioncited by 1
- 2026Tractography-Driven Synthetic Data Generation for Fiber Bundle Segmentation in Tracer Histologycited by 1
- 2026Knowledge-Guided 3D CT Generation: A Conditioning-Centric Taxonomycited by 1
- 2025Efficient and robust 3D blind harmonization for large domain gapscited by 0
- 2025MInDI-3D: Iterative Deep Learning in 3D for Sparse-view Cone Beam Computed Tomographycited by 0
- 2025Towards Diagnostic Quality Flat-Panel Detector CT Imaging Using Diffusion Modelscited by 0
- 2026Knowledge-Guided 3D CT Generation: A Conditioning-Centric Taxonomy7 Aug 2026
- 2026Tractography-Driven Synthetic Data Generation for Fiber Bundle Segmentation in Tracer Histology25 Jun 2026
- 2026Treatment-Conditioned Diffusion for Forecasting Neurodegenerative Disease Progression28 May 2026
- 2025Towards Diagnostic Quality Flat-Panel Detector CT Imaging Using Diffusion Models22 Aug 2025
- 2025MInDI-3D: Iterative Deep Learning in 3D for Sparse-view Cone Beam Computed Tomography13 Aug 2025
- 2025Evaluation of 3D Counterfactual Brain MRI Generation4 Aug 2025
- 2025Efficient and robust 3D blind harmonization for large domain gaps30 Apr 2025
- 2024vesselFM: A Foundation Model for Universal 3D Blood Vessel Segmentation26 Nov 2024
Similar, not cited
Close in wording, no citation either way
- 2025Generative Artificial Intelligence in Medical Imaging: Foundations, Progress, and Clinical Translation
- 2023Deep Learning Approaches for Data Augmentation in Medical Imaging: A Review
- 2024Generative AI for Synthetic Data Across Multiple Medical Modalities: A Systematic Review of Recent Developments and Challenges
- 2024Addressing Small and Imbalanced Medical Image Datasets Using Generative Models: A Comparative Study of DDPM and PGGANs with Random and Greedy K Sampling
- 2024Comparative Analysis of Generative Models: Enhancing Image Synthesis with VAEs, GANs, and Stable Diffusion
- 2025Regression is all you need for medical image translation
- 2024Cross-conditioned Diffusion Model for Medical Image to Image Translation
- 2023Generative AI for Medical Imaging: extending the MONAI Framework