Large-scale Long-tailed Disease Diagnosis on Radiology Images
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Abstract (arXiv)
Developing a generalist radiology diagnosis system can greatly enhance clinical diagnostics. In this paper, we introduce RadDiag, a foundational model supporting 2D and 3D inputs across various modalities and anatomies, using a transformer-based fusion module for comprehensive disease diagnosis. Due to patient privacy concerns and the lack of large-scale radiology diagnosis datasets, we utilize high-quality, clinician-reviewed radiological images available online with diagnosis labels. Our dataset, RP3D-DiagDS, contains 40,936 cases with 195,010 scans covering 5,568 disorders (930 unique ICD-10-CM codes). Experimentally, our RadDiag achieves 95.14% AUC on internal evaluation with the knowledge-enhancement strategy. Additionally, RadDiag can be zero-shot applied or fine-tuned to external diagnosis datasets sourced from various hospitals, demonstrating state-of-the-art results. In conclusion, we show that publicly shared medical data on the Internet is a tremendous and valuable resource that can potentially support building a generalist AI for healthcare.
Key facts. Cited by 17 papers in the map (data through 7 Oct 2026). Builds on 54 of its 107 references that are in the map. First posted on arXiv 26 Dec 2023.
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54 of 107 references.
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Citing papers per year: 2023: 1; 2024: 3; 2025: 8; 2026: 5.
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- 2025CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-raycited by 10
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- 2025From Generic to Specialized: A Subspecialty Diagnostic System Powered by Self-Supervised Learning for Cervical Histopathology11 Oct 2025
- 2025Ontology-Based Concept Distillation for Radiology Report Retrieval and Labeling27 Aug 2025
- 2025Chiron-o1: Igniting Multimodal Large Language Models towards Generalizable Medical Reasoning via Mentor-Intern Collaborative Search20 Jun 2025
- 2025CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-ray9 Jun 2025
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- 2025Empowering Functional Neuroimaging: A Pre-trained Generative Framework for Unified Representation of Neural Signals3 Jun 2025
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- 2023Large-Vocabulary Segmentation for Medical Images with Text Prompts28 Dec 2023
- 2024RaTEScore: A Metric for Radiology Report Generationcited by 65
- 2023Large-Vocabulary Segmentation for Medical Images with Text Promptscited by 60
- 2024Large Language Model Benchmarks in Medical Taskscited by 16
- 2025CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-raycited by 10
- 2025Rethinking Whole-Body CT Image Interpretation: An Abnormality-Centric Approachcited by 2
- 2025R2Seg: Training-Free OOD Medical Tumor Segmentation via Anatomical Reasoning and Statistical Rejectioncited by 1
- 2026ProFound: A moderate-sized vision foundation model for multi-task prostate imagingcited by 1
- 2025Empowering Functional Neuroimaging: A Pre-trained Generative Framework for Unified Representation of Neural Signalscited by 0
- 2025From Generic to Specialized: A Subspecialty Diagnostic System Powered by Self-Supervised Learning for Cervical Histopathologycited by 0
- 2026Early Intervention for VFM-based Multimodal Medical Image Classificationcited by 0
- 2026Dementia Etiology Diagnosis via Collaborative Meta Knowledge Enhancementcited by 0
- 2026Generalized Biomedicine Discoverycited by 0
- 2026Generalized Biomedicine Discovery9 Sep 2026
- 2026Dementia Etiology Diagnosis via Collaborative Meta Knowledge Enhancement24 Jul 2026
- 2026Early Intervention for VFM-based Multimodal Medical Image Classification18 Mar 2026
- 2026ProFound: A moderate-sized vision foundation model for multi-task prostate imaging4 Mar 2026
- 2025R2Seg: Training-Free OOD Medical Tumor Segmentation via Anatomical Reasoning and Statistical Rejection16 Nov 2025
- 2025From Generic to Specialized: A Subspecialty Diagnostic System Powered by Self-Supervised Learning for Cervical Histopathology11 Oct 2025
- 2025CXR-LT 2024: A MICCAI challenge on long-tailed, multi-label, and zero-shot disease classification from chest X-ray9 Jun 2025
- 2025Rethinking Whole-Body CT Image Interpretation: An Abnormality-Centric Approach3 Jun 2025
- 2025Empowering Functional Neuroimaging: A Pre-trained Generative Framework for Unified Representation of Neural Signals3 Jun 2025
- 2024Large Language Model Benchmarks in Medical Tasks28 Oct 2024
- 2024RaTEScore: A Metric for Radiology Report Generation24 Jun 2024
- 2023Large-Vocabulary Segmentation for Medical Images with Text Prompts28 Dec 2023