Clinical Camel: An Open Expert-Level Medical Language Model with Dialogue-Based Knowledge Encoding
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Abstract (arXiv)
We present Clinical Camel, an open large language model (LLM) explicitly tailored for clinical research. Fine-tuned from LLaMA-2 using QLoRA, Clinical Camel achieves state-of-the-art performance across medical benchmarks among openly available medical LLMs. Leveraging efficient single-GPU training, Clinical Camel surpasses GPT-3.5 in five-shot evaluations on all assessed benchmarks, including 64.3% on the USMLE Sample Exam (compared to 58.5% for GPT-3.5), 77.9% on PubMedQA (compared to 60.2%), 60.7% on MedQA (compared to 53.6%), and 54.2% on MedMCQA (compared to 51.0%). In addition to these benchmarks, Clinical Camel demonstrates its broader capabilities, such as synthesizing plausible clinical notes. This work introduces dialogue-based knowledge encoding, a novel method to synthesize conversational data from dense medical texts. While benchmark results are encouraging, extensive and rigorous human evaluation across diverse clinical scenarios is imperative to ascertain safety before implementation. By openly sharing Clinical Camel, we hope to foster transparent and collaborative research, working towards the safe integration of LLMs within the healthcare domain. Significant challenges concerning reliability, bias, and the potential for outdated knowledge persist. Nonetheless, the transparency provided by an open approach reinforces the scientific rigor essential for future clinical applications.
Key facts. Cited by 71 papers in the map (data through 7 Oct 2026). Builds on 7 of its 15 references that are in the map. First posted on arXiv 19 May 2023.
Builds on
7 of 15 references.
References · 7
- 2022Survey of Hallucination in Natural Language Generationcited by 2,056
- 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
- 2022Mass-Editing Memory in a Transformercited by 976
- 2021Retrieval Augmentation Reduces Hallucination in Conversationcited by 691
- 2023Capabilities of GPT-4 on Medical Challenge Problemscited by 630
- 2023Towards Expert-Level Medical Question Answering with Large Language Modelscited by 382
- 2023MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Datacited by 282
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Citing papers per year: 2023: 2; 2024: 26; 2025: 24; 2026: 19.
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- 2025Collaboration among Multiple Large Language Models for Medical Question Answering22 May 2025
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- 2024Are Clinical T5 Models Better for Clinical Text?8 Dec 2024
- 2024The Limited Impact of Medical Adaptation of Large Language and Vision-Language Models13 Nov 2024
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- 2025Clinical-R1: Empowering Large Language Models for Faithful and Comprehensive Reasoning with Clinical Objective Relative Policy Optimizationcited by 6
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- 2025Gene-R1: Reasoning with Data-Augmented Lightweight LLMs for Gene Set Analysiscited by 1
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- 2026To Adapt or not to Adapt, Rethinking the Value of Medical Knowledge-Aware Large Language Modelscited by 1
- 2026Query-Conditioned Graph Retrieval for Contextualized LLM Reasoning in Personalized Wearable Datacited by 1
- 2026Vital Trace: Protocol-Constrained Patient-State Reasoning for Longitudinal Clinical Trajectoriescited by 0
- 2026Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Modelscited by 0
- 2026Evidence, Logic, and Compliance: Multi-Agent Structured Graph Reasoning with Expert Arbitration for Medical Referralcited by 0
- 2026Evidence, Logic, and Compliance: Multi-Agent Structured Graph Reasoning with Expert Arbitration for Medical Referral31 Aug 2026
- 2026Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Models3 Jul 2026
- 2026Query-Conditioned Graph Retrieval for Contextualized LLM Reasoning in Personalized Wearable Data10 Apr 2026
- 2026To Adapt or not to Adapt, Rethinking the Value of Medical Knowledge-Aware Large Language Models8 Apr 2026
- 2026LLaVA-LE: Large Language-and-Vision Assistant for Lunar Exploration25 Mar 2026
- 2026Vital Trace: Protocol-Constrained Patient-State Reasoning for Longitudinal Clinical Trajectories13 Feb 2026
- 2025MediEval: A Unified Medical Benchmark for Patient-Contextual and Knowledge-Grounded Reasoning in LLMs23 Dec 2025
- 2025Clinical-R1: Empowering Large Language Models for Faithful and Comprehensive Reasoning with Clinical Objective Relative Policy Optimization29 Nov 2025
- 2025Gene-R1: Reasoning with Data-Augmented Lightweight LLMs for Gene Set Analysis11 Sep 2025
- 2025Exploring Efficiency Frontiers of Thinking Budget in Medical Reasoning: Scaling Laws between Computational Resources and Reasoning Quality16 Aug 2025
- 2025ALFA: Aligning LLMs to Ask Good Questions A Case Study in Clinical Reasoning20 Feb 2025
- 2024Small Language Models Learn Enhanced Reasoning Skills from Medical Textbooks30 Mar 2024
- 2025Aligned but Blind: Alignment Increases Implicit Bias by Reducing Awareness of Racecited by 15
- 2026Health-ORSC-Bench: A Benchmark for Measuring Over-Refusal and Safety Completion in Health Contextcited by 4
- 2026ProMedical: Hierarchical Fine-Grained Criteria Modeling for Medical LLM Alignment via Explicit Injectioncited by 2
- 2026PrivMedChat: End-to-End Differentially Private RLHF for Medical Dialogue Systemscited by 0
- 2026ProMedical: Hierarchical Fine-Grained Criteria Modeling for Medical LLM Alignment via Explicit Injection9 Apr 2026
- 2026PrivMedChat: End-to-End Differentially Private RLHF for Medical Dialogue Systems3 Mar 2026
- 2026Health-ORSC-Bench: A Benchmark for Measuring Over-Refusal and Safety Completion in Health Context25 Jan 2026
- 2025Aligned but Blind: Alignment Increases Implicit Bias by Reducing Awareness of Race30 May 2025
- 2025From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discoverycited by 74
- 2025A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontierscited by 34
- 2026CuraView: A Multi-Agent Framework for Medical Hallucination Detection with GraphRAG-Enhanced Knowledge Verificationcited by 1
- 2026CuraView: A Multi-Agent Framework for Medical Hallucination Detection with GraphRAG-Enhanced Knowledge Verification5 May 2026
- 2025A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers28 Aug 2025
- 2025From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery18 Aug 2025
- 2023MEDITRON-70B: Scaling Medical Pretraining for Large Language Modelscited by 272
- 2024Capabilities of Gemini Models in Medicinecited by 231
- 2024ECG-FM: An Open Electrocardiogram Foundation Modelcited by 89
- 2024Med42-v2: A Suite of Clinical LLMscited by 89
- 2024Advancing Multimodal Medical Capabilities of Geminicited by 88
- 2024Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Datacited by 65
- 2023MedAlign: A Clinician-Generated Dataset for Instruction Following with Electronic Medical Recordscited by 54
- 2024Med42 -- Evaluating Fine-Tuning Strategies for Medical LLMs: Full-Parameter vs. Parameter-Efficient Approachescited by 51
- 2024DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer's Disease Questions with Scientific Literaturecited by 50
- 2025MedResearcher-R1: Expert-Level Medical Deep Researcher via A Knowledge-Informed Trajectory Synthesis Frameworkcited by 22
- 2024Biomedical Large Languages Models Seem not to be Superior to Generalist Models on Unseen Medical Datacited by 21
- 2024OpenMedLM: Prompt engineering can out-perform fine-tuning in medical question-answering with open-source large language modelscited by 20
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- 2026Dissecting Neuro-Symbolic Quality Assurance for Synthetic Oncology Data Generation22 Aug 2026
- 2026How sensitive do we want AI to be? Socio-communicative competencies of large language models in healthcare29 Jun 2026
- 2026When Cases Get Rare: A Retrieval Benchmark for Off-Guideline Clinical Question Answering20 May 2026
- 2026Can Continual Pre-training Bridge the Performance Gap between General-purpose and Specialized Language Models in the Medical Domain?21 Apr 2026
- 2026Emulating Clinician Cognition via Self-Evolving Deep Clinical Research11 Mar 2026
- 2026PET-F2I: A Comprehensive Benchmark and Parameter-Efficient Fine-Tuning of LLMs for PET/CT Report Impression Generation11 Mar 2026
- 2025Towards Explainable Conversational AI for Early Diagnosis with Large Language Models19 Dec 2025
- 2025Mitigating hallucinations in healthcare LLMs with granular fact-checking and domain-specific adaptation18 Dec 2025
- 2025Enhancing the Medical Context-Awareness Ability of LLMs via Multifaceted Self-Refinement Learning13 Nov 2025
- 2025Citrus-V: Advancing Medical Foundation Models with Unified Medical Image Grounding for Clinical Reasoning23 Sep 2025
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