Explainable AI And Visual Reasoning: Insights From Radiology
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Why do explainable AI (XAI) explanations in radiology, despite their promise of transparency, still fail to gain human trust? Current XAI approaches provide justification for predictions, however, these do not meet practitioners' needs. These XAI explanations lack intuitive coverage of the evidentiary basis for a given classification, posing a significant barrier to adoption. We posit that XAI explanations that mirror human processes of reasoning and justification with evidence may be more useful and trustworthy than traditional visual explanations like heat maps. Using a radiology case study, we demonstrate how radiology practitioners get other practitioners to see a diagnostic conclusion's validity. Machine-learned classifications lack this evidentiary grounding and consequently fail to elicit trust and adoption by potential users. Insights from this study may generalize to guiding principles for human-centered explanation design based on human reasoning and justification of evidence.
Key facts. Cited by 5 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 12 of its 41 references that are in the map. First posted on arXiv 6 Apr 2023.
Builds on
12 of 41 references.
References · 12
- 2016Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localizationcited by 6,690
- 2016"Why Should I Trust You?": Explaining the Predictions of Any Classifiercited by 5,040
- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
- 2017Explanation in Artificial Intelligence: Insights from the Social Sciencescited by 1,201
- 2017CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learningcited by 459
- 2020COVID-Net: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases from Chest X-Ray Imagescited by 264
- 2020Can AI help in screening Viral and COVID-19 pneumonia?cited by 200
- 2017What do we need to build explainable AI systems for the medical domain?cited by 127
- 2021Expanding Explainability: Towards Social Transparency in AI systemscited by 124
- 2019Explanation in Human-AI Systems: A Literature Meta-Review, Synopsis of Key Ideas and Publications, and Bibliography for Explainable AIcited by 63
- 2020CheXplain: Enabling Physicians to Explore and UnderstandData-Driven, AI-Enabled Medical Imaging Analysiscited by 40
- 2021Principles of Explanation in Human-AI Systemscited by 25
Built on by
Citing papers per year: 2024: 4; 2025: 1.
5 papers.
- 2024Effects of Multimodal Explanations for Autonomous Driving on Driving Performance, Cognitive Load, Expertise, Confidence, and Trustcited by 3
- 2024What Did My Car Say? Impact of Autonomous Vehicle Explanation Errors and Driving Context On Comfort, Reliance, Satisfaction, and Driving Confidencecited by 3
- 2024Developing Situational Awareness for Joint Action with Autonomous Vehiclescited by 2
- 2024Predicting Trust In Autonomous Vehicles: Modeling Young Adult Psychosocial Traits, Risk-Benefit Attitudes, And Driving Factors With Machine Learningcited by 2
- 2025Visual-Conversational Interface for Evidence-Based Explanation of Diabetes Risk Predictioncited by 2
- 2025Visual-Conversational Interface for Evidence-Based Explanation of Diabetes Risk Prediction25 Jun 2025
- 2024Predicting Trust In Autonomous Vehicles: Modeling Young Adult Psychosocial Traits, Risk-Benefit Attitudes, And Driving Factors With Machine Learning13 Sep 2024
- 2024What Did My Car Say? Impact of Autonomous Vehicle Explanation Errors and Driving Context On Comfort, Reliance, Satisfaction, and Driving Confidence9 Sep 2024
- 2024Developing Situational Awareness for Joint Action with Autonomous Vehicles17 Apr 2024
- 2024Effects of Multimodal Explanations for Autonomous Driving on Driving Performance, Cognitive Load, Expertise, Confidence, and Trust8 Jan 2024
Similar, not cited
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- 2025A Survey on Human-Centered Evaluation of Explainable AI Methods in Clinical Decision Support Systems
- 2026A radiographic world model for clinical reasoning and evidence generation
- 2025Reasoning Visual Language Model for Chest X-Ray Analysis
- 2025RadAgents: Multimodal Agentic Reasoning for Chest X-ray Interpretation with Radiologist-like Workflows
- 2023Diagrammatization and Abduction to Improve AI Interpretability With Domain-Aligned Explanations for Medical Diagnosis
- 2026Towards Responsible Multimodal Medical Reasoning via Context-Aligned Vision-Language Models
- 2025Radiology's Last Exam (RadLE): Benchmarking Frontier Multimodal AI Against Human Experts and a Taxonomy of Visual Reasoning Errors in Radiology
- 2026KANEx: Translating Kolmogorov-Arnold Networks' Interpretability to Medical Explainability