mlsanityData to 7 Oct 2026

Reasoning Visual Language Model for Chest X-Ray Analysis

arXiv 2510.23968 ↗First posted 28 Oct 2025cs.CVcited by 8

On the map: LLM reasoning → Clinical and biomedical applications

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Abstract (arXiv)

Vision-language models (VLMs) have shown strong promise for medical image analysis, but most remain opaque, offering predictions without the transparent, stepwise reasoning clinicians rely on. We present a framework that brings chain-of-thought (CoT) reasoning to chest X-ray interpretation. Inspired by reasoning-first training paradigms, our approach is designed to learn how experts reason, not just what they conclude, by aligning intermediate steps with observable image evidence and radiology workflow. Beyond accuracy, the explicit reasoning traces support clinical auditability: they reveal why a conclusion was reached, which alternatives were considered, and where uncertainty remains, enabling quality assurance, error analysis, and safer human-AI collaboration. Our model couples high-fidelity visual encoding with a two-stage training recipe: a reasoning-style supervised fine-tuning (SFT) followed by reinforcement learning (RL) that uses verifiable rewards over a list of X-ray abnormalities. The model outputs reasoning that mirrors radiologists systematic thought process, uncertainty, and differential diagnosis. In out-of-distribution evaluation, the approach achieves competitive multi-label classification while improving interpretability. In a reader study with expert radiologists, full reasoning traces increased confidence, supported error auditing, and reduced time to finalize reports. We release code and the model NV-Reason-CXR-3B to support community progress toward trustworthy, explainable AI in chest radiography and other medical imaging tasks where reasoning quality is as critical as prediction quality.

Key facts. Cited by 8 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 13 of its 38 references that are in the map. First posted on arXiv 28 Oct 2025.

Builds on

13 of 38 references.

References · 13

  1. 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,302
  2. 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 8,851
  3. 2023Direct Preference Optimization: Your Language Model is Secretly a Reward Modelcited by 7,916
  4. 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,146
  5. 2025Qwen2.5-VL Technical Reportcited by 5,418
  6. 2022Robust Speech Recognition via Large-Scale Weak Supervisioncited by 3,972
  7. 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
  8. 2017ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseasescited by 969
  9. 2019MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographscited by 590
  10. 2025MedGemma Technical Reportcited by 398
  11. 2024Capabilities of Gemini Models in Medicinecited by 231
  12. 2024Advancing Multimodal Medical Capabilities of Geminicited by 88
1 more
  1. 2025On the Robustness of Medical Vision-Language Models: Are they Truly Generalizable?cited by 10

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2025: 1; 2026: 7.

8 papers.

Similar, not cited

Close in wording, no citation either way

  1. 2025X-Ray-CoT: Interpretable Chest X-ray Diagnosis with Vision-Language Models via Chain-of-Thought Reasoning
  2. 2026Enhancing Visual Reasoning in Chest X-Ray Report Generation Using Reinforcement Learning
  3. 2025ChestX-Reasoner: Advancing Radiology Foundation Models with Reasoning through Step-by-Step Verification
  4. 2025CX-Mind: A Pioneering Multimodal Large Language Model for Interleaved Reasoning in Chest X-ray via Curriculum-Guided Reinforcement Learning
  5. 2024CXR-Agent: Vision-language models for chest X-ray interpretation with uncertainty aware radiology reporting
  6. 2025Enhancing Radiology Report Generation and Visual Grounding using Reinforcement Learning
  7. 2025Evaluating Reasoning Faithfulness in Medical Vision-Language Models using Multimodal Perturbations
  8. 2026Toward Guarantees for Clinical Reasoning in Vision Language Models via Formal Verification