A Deep Generative Model of Neonatal Cortical Surface Development
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Abstract (arXiv)
The neonatal cortical surface is known to be affected by preterm birth, and the subsequent changes to cortical organisation have been associated with poorer neurodevelopmental outcomes. Deep Generative models have the potential to lead to clinically interpretable models of disease, but developing these on the cortical surface is challenging since established techniques for learning convolutional filters are inappropriate on non-flat topologies. To close this gap, we implement a surface-based CycleGAN using mixture model CNNs (MoNet) to translate sphericalised neonatal cortical surface features (curvature and T1w/T2w cortical myelin) between different stages of cortical maturity. Results show our method is able to reliably predict changes in individual patterns of cortical organisation at later stages of gestation, validated by comparison to longitudinal data; and translate appearance between preterm and term gestation (> 37 weeks gestation), validated through comparison with a trained term/preterm classifier. Simulated differences in cortical maturation are consistent with observations in the literature.
Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Builds on 24 of its 48 references that are in the map. First posted on arXiv 15 Jun 2022.
Builds on
24 of 48 references.
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12 more
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Citing papers per year: 2024: 1.
1 paper.
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