mlsanityData to 7 Oct 2026

Unpaired Brain MR-to-CT Synthesis using a Structure-Constrained CycleGAN

arXiv 1809.04536 ↗First posted 12 Sep 2018cs.CVcited by 31

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Abstract (arXiv)

The cycleGAN is becoming an influential method in medical image synthesis. However, due to a lack of direct constraints between input and synthetic images, the cycleGAN cannot guarantee structural consistency between these two images, and such consistency is of extreme importance in medical imaging. To overcome this, we propose a structure-constrained cycleGAN for brain MR-to-CT synthesis using unpaired data that defines an extra structure-consistency loss based on the modality independent neighborhood descriptor to constrain structural consistency. Additionally, we use a position-based selection strategy for selecting training images instead of a completely random selection scheme. Experimental results on synthesizing CT images from brain MR images demonstrate that our method is better than the conventional cycleGAN and approximates the cycleGAN trained with paired data.

Key facts. Cited by 31 papers in the map (data through 7 Oct 2026). First posted on arXiv 12 Sep 2018.

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Citing papers per year: 2021: 4; 2022: 7; 2023: 6; 2024: 8; 2025: 6.

31 papers.

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  1. 2022Unsupervised Medical Image Translation with Adversarial Diffusion Modelscited by 191
  2. 2021ResViT: Residual vision transformers for multi-modal medical image synthesiscited by 177
  3. 2022Diffusion Deformable Model for 4D Temporal Medical Image Generationcited by 65
  4. 2023Synthetic CT Generation from MRI using 3D Transformer-based Denoising Diffusion Modelcited by 29
  5. 2024Self-Consistent Recursive Diffusion Bridge for Medical Image Translationcited by 26
  6. 2024I2I-Mamba: Multi-modal medical image synthesis via selective state space modelingcited by 26
  7. 2023Structure-Preserving Synthesis: MaskGAN for Unpaired MR-CT Translationcited by 19
  8. 2022HACA3: A Unified Approach for Multi-site MR Image Harmonizationcited by 17
  9. 2024Data-Efficient Unsupervised Interpolation Without Any Intermediate Frame for 4D Medical Imagescited by 15
  10. 2021METGAN: Generative Tumour Inpainting and Modality Synthesis in Light Sheet Microscopycited by 9
  11. 2023This Intestine Does Not Exist: Multiscale Residual Variational Autoencoder for Realistic Wireless Capsule Endoscopy Image Generationcited by 9
  12. 2024Structural Attention: Rethinking Transformer for Unpaired Medical Image Synthesiscited by 8
19 more
  1. 2024Quantitative Metrics for Benchmarking Medical Image Harmonizationcited by 6
  2. 2021Unsupervised-learning-based method for chest MRI-CT transformation using structure constrained unsupervised generative attention networkscited by 4
  3. 2022Deep learning based domain adaptation for mitochondria segmentation on EM volumescited by 2
  4. 2022Unsupervised Joint Image Transfer and Uncertainty Quantification Using Patch Invariant Networkscited by 2
  5. 2023A Novel Deep Learning Technique for Morphology Preserved Fetal ECG Extraction from Mother ECG using 1D-CycleGANcited by 2
  6. 2024Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PETcited by 2
  7. 2025From Traditional to Deep Learning Approaches in Whole Slide Image Registration: A Methodological Reviewcited by 2
  8. 2025Multiscale Vector-Quantized Variational Autoencoder for Endoscopic Image Synthesiscited by 2
  9. 2022A Deep Generative Model of Neonatal Cortical Surface Developmentcited by 1
  10. 2022Longitudinal Prediction of Postnatal Brain Magnetic Resonance Images via a Metamorphic Generative Adversarial Networkcited by 1
  11. 2024Cross-Domain Distribution Alignment for Segmentation of Private Unannotated 3D Medical Imagescited by 1
  12. 2024Enhancing frozen histological section images using permanent-section-guided deep learning with nuclei attentioncited by 1
  13. 2025Coarse-to-Fine Joint Registration of MR and Ultrasound Images via Imaging Style Transfercited by 1
  14. 2025Biology-driven assessment of deep learning super-resolution imaging of the porosity network in dentincited by 1
  15. 2025MCR-VQGAN: A Scalable and Cost-Effective Tau PET Synthesis Approach for Alzheimer's Disease Imagingcited by 1
  16. 2021Exploring constraints on CycleGAN-based CBCT enhancement for adaptive radiotherapycited by 0
  17. 2023Harmonization Across Imaging Locations(HAIL): One-Shot Learning for Brain MRIcited by 0
  18. 2023Constrained CycleGAN for Effective Generation of Ultrasound Sector Images of Improved Spatial Resolutioncited by 0
  19. 2025Plasticine: A Traceable Diffusion Model for Medical Image Translationcited by 0