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Vox2Vox: 3D-GAN for Brain Tumour Segmentation

arXiv 2003.13653 ↗First posted 19 Mar 2020cs.CV cs.LG eess.IVcited by 30

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Abstract (arXiv)

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histological sub-regions, i.e., peritumoral edema, necrotic core, enhancing and non-enhancing tumour core. Although brain tumours can easily be detected using multi-modal MRI, accurate tumor segmentation is a challenging task. Hence, using the data provided by the BraTS Challenge 2020, we propose a 3D volume-to-volume Generative Adversarial Network for segmentation of brain tumours. The model, called Vox2Vox, generates realistic segmentation outputs from multi-channel 3D MR images, segmenting the whole, core and enhancing tumor with mean values of 87.20%, 81.14%, and 78.67% as dice scores and 6.44mm, 24.36mm, and 18.95mm for Hausdorff distance 95 percentile for the BraTS testing set after ensembling 10 Vox2Vox models obtained with a 10-fold cross-validation.

Key facts. Cited by 30 papers in the map (data through 7 Oct 2026). First posted on arXiv 19 Mar 2020.

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Citing papers per year: 2021: 3; 2022: 6; 2023: 7; 2024: 5; 2025: 7; 2026: 2.

30 papers.

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  1. 2023MedSyn: Text-guided Anatomy-aware Synthesis of High-Fidelity 3D CT Imagescited by 41
  2. 20243D MedDiffusion: A 3D Medical Latent Diffusion Model for Controllable and High-quality Medical Image Generationcited by 37
  3. 2021Data synthesis and adversarial networks: A review and meta-analysis in cancer imagingcited by 15
  4. 2021Is Image-to-Image Translation the Panacea for Multimodal Image Registration? A Comparative Studycited by 9
  5. 2022Reciprocal Adversarial Learning for Brain Tumor Segmentation: A Solution to BraTS Challenge 2021 Segmentation Taskcited by 9
  6. 2024A Data Augmentation Pipeline to Generate Synthetic Labeled Datasets of 3D Echocardiography Images using a GANcited by 6
  7. 2021HAD-Net: A Hierarchical Adversarial Knowledge Distillation Network for Improved Enhanced Tumour Segmentation Without Post-Contrast Imagescited by 5
  8. 20223D Brain and Heart Volume Generative Models: A Surveycited by 4
  9. 2024Blaze3DM: Marry Triplane Representation with Diffusion for 3D Medical Inverse Problem Solvingcited by 4
  10. 2025DMCIE: Diffusion Model with Concatenation of Inputs and Errors to Improve the Accuracy of the Segmentation of Brain Tumors in MRI Imagescited by 4
  11. 2022MDA GAN: Adversarial-Learning-based 3-D Seismic Data Interpolation and Reconstruction for Complex Missingcited by 3
  12. 2022Generative Adversarial Networks and Other Generative Modelscited by 3
18 more
  1. 2025ReCoSeg++:Extended Residual-Guided Cross-Modal Diffusion for Brain Tumor Segmentationcited by 3
  2. 2022Soft-CP: A Credible and Effective Data Augmentation for Semantic Segmentation of Medical Lesionscited by 2
  3. 2023Performance of GAN-based augmentation for deep learning COVID-19 image classificationcited by 2
  4. 2022A Deep Generative Model of Neonatal Cortical Surface Developmentcited by 1
  5. 2023Fast refacing of MR images with a generative neural network lowers re-identification risk and preserves volumetric consistencycited by 1
  6. 2023Causal Image Synthesis of Brain MR in 3Dcited by 0
  7. 2023Learned Local Attention Maps for Synthesising Vessel Segmentationscited by 0
  8. 2023DeepVox and SAVE-CT: a contrast- and dose-independent 3D deep learning approach for thoracic aorta segmentation and aneurysm prediction using computed tomography scanscited by 0
  9. 20233D EAGAN: 3D edge-aware attention generative adversarial network for prostate segmentation in transrectal ultrasound imagescited by 0
  10. 2024Interpretability of Uncertainty: Exploring Cortical Lesion Segmentation in Multiple Sclerosiscited by 0
  11. 2024Multimodal 3D Brain Tumor Segmentation with Adversarial Training and Conditional Random Fieldcited by 0
  12. 2025Comparative clinical evaluation of "memory-efficient" synthetic 3d generative adversarial networks (gan) head-to-head to state of art: results on computed tomography of the chestcited by 0
  13. 2025Memory-Efficient 3D High-Resolution Medical Image Synthesis Using CRF-Guided GANscited by 0
  14. 2025Characterizing Nash Equilibria in Zero-Sum Games: A Physics-Inspired, Parallelizable Approach with a Linear Number of Gradient Queriescited by 0
  15. 2025SYNAPSE-Net: A Unified Framework with Lesion-Aware Hierarchical Gating for Robust Segmentation of Heterogeneous Brain Lesionscited by 0
  16. 2025Precise Liver Tumor Segmentation in CT Using a Hybrid Deep Learning-Radiomics Frameworkcited by 0
  17. 2026A Novel Global Context-aware Deep Neural Network for Enhanced Brain Tumor Segmentation using Magnetic Resonance Imagescited by 0
  18. 2026TCAM-Diff: Triplane-Aware Cross-Attention Medical Diffusion Modelcited by 0