mlsanityData to 7 Oct 2026

Clinical Prompt Learning with Frozen Language Models

arXiv 2205.05535 ↗First posted 11 May 2022cs.CLcited by 19

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Abstract (arXiv)

Prompt learning is a new paradigm in the Natural Language Processing (NLP) field which has shown impressive performance on a number of natural language tasks with common benchmarking text datasets in full, few-shot, and zero-shot train-evaluation setups. Recently, it has even been observed that large but frozen pre-trained language models (PLMs) with prompt learning outperform smaller but fine-tuned models. However, as with many recent NLP trends, the performance of even the largest PLMs such as GPT-3 do not perform well on specialized domains (e.g. medical text), and the common practice to achieve State of the Art (SoTA) results still consists of pre-training and fine-tuning the PLMs on downstream tasks. The reliance on fine-tuning large PLMs is problematic in clinical settings where data is often held in non-GPU environments, and more resource efficient methods of training specialized domain models is crucial. We investigated the viability of prompt learning on clinically meaningful decision tasks and directly compared with more traditional fine-tuning methods. Results are partially in line with the prompt learning literature, with prompt learning able to match or improve on traditional fine-tuning with substantially fewer trainable parameters and requiring less training data. We argue that prompt learning therefore provides lower computational resource costs applicable to clinical settings, that can serve as an alternative to fine-tuning ever increasing in size PLMs. Complementary code to reproduce experiments presented in this work can be found at: https://github.com/NtaylorOX/Public_Clinical_Prompt.

Key facts. Cited by 19 papers in the map (data through 7 Oct 2026). Builds on 36 of its 48 references that are in the map. First posted on arXiv 11 May 2022.

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36 of 48 references.

References · 36

  1. 2018BERT: Pre-training of Deep Bidirectional Transformers for Language Understandingcited by 40,204
  2. 2020Language Models are Few-Shot Learnerscited by 32,199
  3. 2019Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformercited by 14,491
  4. 2021Prefix-Tuning: Optimizing Continuous Prompts for Generationcited by 3,878
  5. 2021The Power of Scale for Parameter-Efficient Prompt Tuningcited by 3,769
  6. 2022OPT: Open Pre-trained Transformer Language Modelscited by 3,464
  7. 2021Pre-train, Prompt, and Predict: A Systematic Survey of Prompting Methods in Natural Language Processingcited by 2,222
  8. 2019BioBERT: a pre-trained biomedical language representation model for biomedical text miningcited by 1,935
  9. 2020Don't Stop Pretraining: Adapt Language Models to Domains and Taskscited by 1,548
  10. 2021Multitask Prompted Training Enables Zero-Shot Task Generalizationcited by 1,462
  11. 2020Domain-Specific Language Model Pretraining for Biomedical Natural Language Processingcited by 996
  12. 2019Publicly Available Clinical BERT Embeddingscited by 995
24 more
  1. 2020Exploiting Cloze Questions for Few Shot Text Classification and Natural Language Inferencecited by 934
  2. 2018Adafactor: Adaptive Learning Rates with Sublinear Memory Costcited by 896
  3. 2021P-Tuning v2: Prompt Tuning Can Be Comparable to Fine-tuning Universally Across Scales and Taskscited by 686
  4. 2021Multimodal Few-Shot Learning with Frozen Language Modelscited by 657
  5. 2018Annotation Artifacts in Natural Language Inference Datacited by 656
  6. 2022Using DeepSpeed and Megatron to Train Megatron-Turing NLG 530B, A Large-Scale Generative Language Modelcited by 557
  7. 2019ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmissioncited by 487
  8. 2019Transfer Learning in Biomedical Natural Language Processing: An Evaluation of BERT and ELMo on Ten Benchmarking Datasetscited by 298
  9. 2021WARP: Word-level Adversarial ReProgrammingcited by 220
  10. 2019Probing Neural Network Comprehension of Natural Language Argumentscited by 212
  11. 2021Knowledgeable Prompt-tuning: Incorporating Knowledge into Prompt Verbalizer for Text Classificationcited by 183
  12. 2020Recall and Learn: Fine-tuning Deep Pretrained Language Models with Less Forgettingcited by 169
  13. 2021Pretrained Transformers as Universal Computation Enginescited by 162
  14. 2021OpenPrompt: An Open-source Framework for Prompt-learningcited by 148
  15. 2019MIMIC-Extract: A Data Extraction, Preprocessing, and Representation Pipeline for MIMIC-IIIcited by 121
  16. 2022Code Synonyms Do Matter: Multiple Synonyms Matching Network for Automatic ICD Codingcited by 52
  17. 2021Clinical Outcome Prediction from Admission Notes using Self-Supervised Knowledge Integrationcited by 43
  18. 2021GPT-3 Models are Poor Few-Shot Learners in the Biomedical Domaincited by 36
  19. 2021Robust Transfer Learning with Pretrained Language Models through Adapterscited by 35
  20. 2022HealthPrompt: A Zero-shot Learning Paradigm for Clinical Natural Language Processingcited by 26
  21. 2018Few-shot Learning for Named Entity Recognition in Medical Textcited by 19
  22. 2020Med7: a transferable clinical natural language processing model for electronic health recordscited by 15
  23. 2021Rationale production to support clinical decision-makingcited by 3
  24. 2022Unsupervised Pre-Training on Patient Population Graphs for Patient-Level Predictionscited by 2

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Citing papers per year: 2022: 3; 2023: 7; 2024: 8; 2025: 1.

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  1. 2023Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Modelscited by 58
  2. 2023Prompt Engineering for Healthcare: Methodologies and Applicationscited by 52
  3. 2023Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physicscited by 49
  4. 2022Knowledge Injected Prompt Based Fine-tuning for Multi-label Few-shot ICD Codingcited by 40
  5. 2024Few-shot Adaptation of Medical Vision-Language Modelscited by 22
  6. 2023Identifying and Extracting Rare Disease Phenotypes with Large Language Modelscited by 18
  7. 2022Multi-label Few-shot ICD Coding as Autoregressive Generation with Promptcited by 16
  8. 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practicescited by 13
  9. 2022Exploiting prompt learning with pre-trained language models for Alzheimer's Disease detectioncited by 6
  10. 2023Surpassing GPT-4 Medical Coding with a Two-Stage Approachcited by 6
  11. 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Taskscited by 4
  12. 2025ChronoLLM: Customizing Language Models for Physics-Based Simulation Code Generationcited by 3
7 more
  1. 2023Leveraging GPT-4 for Food Effect Summarization to Enhance Product-Specific Guidance Development via Iterative Promptingcited by 2
  2. 2024Detecting the Clinical Features of Difficult-to-Treat Depression using Synthetic Data from Large Language Modelscited by 2
  3. 2024Clinical information extraction for Low-resource languages with Few-shot learning using Pre-trained language models and Promptingcited by 2
  4. 2024Bespoke Large Language Models for Digital Triage Assistance in Mental Health Carecited by 1
  5. 2024Developing Healthcare Language Model Embedding Spacescited by 1
  6. 2023Eye-SpatialNet: Spatial Information Extraction from Ophthalmology Notescited by 0
  7. 2024Large Language Models Perform on Par with Experts Identifying Mental Health Factors in Adolescent Online Forumscited by 0