Clinical Prompt Learning with Frozen Language Models
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Abstract (arXiv)
Prompt learning is a new paradigm in the Natural Language Processing (NLP) field which has shown impressive performance on a number of natural language tasks with common benchmarking text datasets in full, few-shot, and zero-shot train-evaluation setups. Recently, it has even been observed that large but frozen pre-trained language models (PLMs) with prompt learning outperform smaller but fine-tuned models. However, as with many recent NLP trends, the performance of even the largest PLMs such as GPT-3 do not perform well on specialized domains (e.g. medical text), and the common practice to achieve State of the Art (SoTA) results still consists of pre-training and fine-tuning the PLMs on downstream tasks. The reliance on fine-tuning large PLMs is problematic in clinical settings where data is often held in non-GPU environments, and more resource efficient methods of training specialized domain models is crucial. We investigated the viability of prompt learning on clinically meaningful decision tasks and directly compared with more traditional fine-tuning methods. Results are partially in line with the prompt learning literature, with prompt learning able to match or improve on traditional fine-tuning with substantially fewer trainable parameters and requiring less training data. We argue that prompt learning therefore provides lower computational resource costs applicable to clinical settings, that can serve as an alternative to fine-tuning ever increasing in size PLMs. Complementary code to reproduce experiments presented in this work can be found at: https://github.com/NtaylorOX/Public_Clinical_Prompt.
Key facts. Cited by 19 papers in the map (data through 7 Oct 2026). Builds on 36 of its 48 references that are in the map. First posted on arXiv 11 May 2022.
Builds on
36 of 48 references.
References · 36
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24 more
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Citing papers per year: 2022: 3; 2023: 7; 2024: 8; 2025: 1.
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- 2023Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Modelscited by 58
- 2023Prompt Engineering for Healthcare: Methodologies and Applicationscited by 52
- 2023Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physicscited by 49
- 2022Knowledge Injected Prompt Based Fine-tuning for Multi-label Few-shot ICD Codingcited by 40
- 2024Few-shot Adaptation of Medical Vision-Language Modelscited by 22
- 2023Identifying and Extracting Rare Disease Phenotypes with Large Language Modelscited by 18
- 2022Multi-label Few-shot ICD Coding as Autoregressive Generation with Promptcited by 16
- 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practicescited by 13
- 2022Exploiting prompt learning with pre-trained language models for Alzheimer's Disease detectioncited by 6
- 2023Surpassing GPT-4 Medical Coding with a Two-Stage Approachcited by 6
- 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Taskscited by 4
- 2025ChronoLLM: Customizing Language Models for Physics-Based Simulation Code Generationcited by 3
7 more
- 2023Leveraging GPT-4 for Food Effect Summarization to Enhance Product-Specific Guidance Development via Iterative Promptingcited by 2
- 2024Detecting the Clinical Features of Difficult-to-Treat Depression using Synthetic Data from Large Language Modelscited by 2
- 2024Clinical information extraction for Low-resource languages with Few-shot learning using Pre-trained language models and Promptingcited by 2
- 2024Bespoke Large Language Models for Digital Triage Assistance in Mental Health Carecited by 1
- 2024Developing Healthcare Language Model Embedding Spacescited by 1
- 2023Eye-SpatialNet: Spatial Information Extraction from Ophthalmology Notescited by 0
- 2024Large Language Models Perform on Par with Experts Identifying Mental Health Factors in Adolescent Online Forumscited by 0
- 2025ChronoLLM: Customizing Language Models for Physics-Based Simulation Code Generation19 Aug 2025
- 2024Few-shot Adaptation of Medical Vision-Language Models5 Sep 2024
- 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practices2 May 2024
- 2024Large Language Models Perform on Par with Experts Identifying Mental Health Factors in Adolescent Online Forums25 Apr 2024
- 2024Developing Healthcare Language Model Embedding Spaces28 Mar 2024
- 2024Bespoke Large Language Models for Digital Triage Assistance in Mental Health Care28 Mar 2024
- 2024Clinical information extraction for Low-resource languages with Few-shot learning using Pre-trained language models and Prompting20 Mar 2024
- 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Tasks16 Feb 2024
- 2024Detecting the Clinical Features of Difficult-to-Treat Depression using Synthetic Data from Large Language Models12 Feb 2024
- 2023Surpassing GPT-4 Medical Coding with a Two-Stage Approach22 Nov 2023
- 2023Leveraging GPT-4 for Food Effect Summarization to Enhance Product-Specific Guidance Development via Iterative Prompting28 Jun 2023
- 2023Identifying and Extracting Rare Disease Phenotypes with Large Language Models22 Jun 2023
7 more
- 2023Eye-SpatialNet: Spatial Information Extraction from Ophthalmology Notes19 May 2023
- 2023Prompt Engineering for Healthcare: Methodologies and Applications28 Apr 2023
- 2023Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics1 Apr 2023
- 2023Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Models10 Mar 2023
- 2022Multi-label Few-shot ICD Coding as Autoregressive Generation with Prompt24 Nov 2022
- 2022Exploiting prompt learning with pre-trained language models for Alzheimer's Disease detection29 Oct 2022
- 2022Knowledge Injected Prompt Based Fine-tuning for Multi-label Few-shot ICD Coding7 Oct 2022
- 2024Few-shot Adaptation of Medical Vision-Language Modelscited by 22
- 2024Few-shot Adaptation of Medical Vision-Language Models5 Sep 2024
- 2023Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Modelscited by 58
- 2023Prompt Engineering for Healthcare: Methodologies and Applicationscited by 52
- 2023Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physicscited by 49
- 2022Knowledge Injected Prompt Based Fine-tuning for Multi-label Few-shot ICD Codingcited by 40
- 2023Identifying and Extracting Rare Disease Phenotypes with Large Language Modelscited by 18
- 2022Multi-label Few-shot ICD Coding as Autoregressive Generation with Promptcited by 16
- 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practicescited by 13
- 2022Exploiting prompt learning with pre-trained language models for Alzheimer's Disease detectioncited by 6
- 2023Surpassing GPT-4 Medical Coding with a Two-Stage Approachcited by 6
- 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Taskscited by 4
- 2025ChronoLLM: Customizing Language Models for Physics-Based Simulation Code Generationcited by 3
- 2023Leveraging GPT-4 for Food Effect Summarization to Enhance Product-Specific Guidance Development via Iterative Promptingcited by 2
12 most cited of 18 All 18 (JSON)
- 2025ChronoLLM: Customizing Language Models for Physics-Based Simulation Code Generation19 Aug 2025
- 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practices2 May 2024
- 2024Large Language Models Perform on Par with Experts Identifying Mental Health Factors in Adolescent Online Forums25 Apr 2024
- 2024Developing Healthcare Language Model Embedding Spaces28 Mar 2024
- 2024Bespoke Large Language Models for Digital Triage Assistance in Mental Health Care28 Mar 2024
- 2024Clinical information extraction for Low-resource languages with Few-shot learning using Pre-trained language models and Prompting20 Mar 2024
- 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Tasks16 Feb 2024
- 2024Detecting the Clinical Features of Difficult-to-Treat Depression using Synthetic Data from Large Language Models12 Feb 2024
- 2023Surpassing GPT-4 Medical Coding with a Two-Stage Approach22 Nov 2023
- 2023Leveraging GPT-4 for Food Effect Summarization to Enhance Product-Specific Guidance Development via Iterative Prompting28 Jun 2023
- 2023Identifying and Extracting Rare Disease Phenotypes with Large Language Models22 Jun 2023
- 2023Eye-SpatialNet: Spatial Information Extraction from Ophthalmology Notes19 May 2023
12 newest of 18 All 18 (JSON)