Integrating Physiological Time Series and Clinical Notes with Transformer for Early Prediction of Sepsis
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Abstract (arXiv)
Sepsis is a leading cause of death in the Intensive Care Units (ICU). Early detection of sepsis is critical for patient survival. In this paper, we propose a multimodal Transformer model for early sepsis prediction, using the physiological time series data and clinical notes for each patient within 36 hours of ICU admission. Specifically, we aim to predict sepsis using only the first 12, 18, 24, 30 and 36 hours of laboratory measurements, vital signs, patient demographics, and clinical notes. We evaluate our model on two large critical care datasets: MIMIC-III and eICU-CRD. The proposed method is compared with six baselines. In addition, ablation analysis and case studies are conducted to study the influence of each individual component of the model and the contribution of each data modality for early sepsis prediction. Experimental results demonstrate the effectiveness of our method, which outperforms competitive baselines on all metrics.
Key facts. Cited by 14 papers in the map (data through 7 Oct 2026). Builds on 22 of its 40 references that are in the map. First posted on arXiv 28 Mar 2022.
Builds on
22 of 40 references.
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10 more
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- 2024Unveiling and Mitigating Bias in Mental Health Analysis with Large Language Modelscited by 5
- 2025DynaGraph: Interpretable Multi-Label Prediction from EHRs via Dynamic Graph Learning and Contrastive Augmentationcited by 2
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- 2024Reinforcement of Explainability of ChatGPT Prompts by Embedding Breast Cancer Self-Screening Rules into AI Responsescited by 1
- 2026CSRA: Controlled Spectral Residual Augmentation for Robust Sepsis Predictioncited by 1
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- 2026OC-Distill: Ontology-aware Contrastive Learning with Cross-Modal Distillation for ICU Risk Prediction18 Apr 2026
- 2026CSRA: Controlled Spectral Residual Augmentation for Robust Sepsis Prediction16 Apr 2026
- 2025DynaGraph: Interpretable Multi-Label Prediction from EHRs via Dynamic Graph Learning and Contrastive Augmentation28 Mar 2025
- 2024Unveiling and Mitigating Bias in Mental Health Analysis with Large Language Models17 Jun 2024
- 2024Reinforcement of Explainability of ChatGPT Prompts by Embedding Breast Cancer Self-Screening Rules into AI Responses21 Apr 2024
- 2024SportQA: A Benchmark for Sports Understanding in Large Language Models24 Feb 2024
- 2024FairEHR-CLP: Towards Fairness-Aware Clinical Predictions with Contrastive Learning in Multimodal Electronic Health Records1 Feb 2024
- 2023XAI for In-hospital Mortality Prediction via Multimodal ICU Data29 Dec 2023
- 2023Missing-modality Enabled Multi-modal Fusion Architecture for Medical Data27 Sep 2023
- 2023Metacognitive Prompting Improves Understanding in Large Language Models10 Aug 2023
- 2023Are Large Language Models Ready for Healthcare? A Comparative Study on Clinical Language Understanding9 Apr 2023