mlsanityData to 7 Oct 2026

Efficient Medical Image Segmentation Based on Knowledge Distillation

arXiv 2108.09987 ↗First posted 23 Aug 2021eess.IV cs.CVcited by 43

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Abstract (arXiv)

Recent advances have been made in applying convolutional neural networks to achieve more precise prediction results for medical image segmentation problems. However, the success of existing methods has highly relied on huge computational complexity and massive storage, which is impractical in the real-world scenario. To deal with this problem, we propose an efficient architecture by distilling knowledge from well-trained medical image segmentation networks to train another lightweight network. This architecture empowers the lightweight network to get a significant improvement on segmentation capability while retaining its runtime efficiency. We further devise a novel distillation module tailored for medical image segmentation to transfer semantic region information from teacher to student network. It forces the student network to mimic the extent of difference of representations calculated from different tissue regions. This module avoids the ambiguous boundary problem encountered when dealing with medical imaging but instead encodes the internal information of each semantic region for transferring. Benefited from our module, the lightweight network could receive an improvement of up to 32.6% in our experiment while maintaining its portability in the inference phase. The entire structure has been verified on two widely accepted public CT datasets LiTS17 and KiTS19. We demonstrate that a lightweight network distilled by our method has non-negligible value in the scenario which requires relatively high operating speed and low storage usage.

Key facts. Cited by 43 papers in the map (data through 7 Oct 2026). Builds on 42 of its 62 references that are in the map. First posted on arXiv 23 Aug 2021.

Builds on

42 of 62 references.

References · 42

  1. 2017Attention Is All You Needcited by 59,932
  2. 2015Deep Residual Learning for Image Recognitioncited by 51,809
  3. 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
  4. 2015Distilling the Knowledge in a Neural Networkcited by 10,076
  5. 2016Densely Connected Convolutional Networkscited by 6,691
  6. 2018MobileNetV2: Inverted Residuals and Linear Bottleneckscited by 4,773
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30 more
  1. 2017ShuffleNet: An Extremely Efficient Convolutional Neural Network for Mobile Devicescited by 1,194
  2. 2015Multi-Scale Context Aggregation by Dilated Convolutionscited by 1,128
  3. 2016Paying More Attention to Attention: Improving the Performance of Convolutional Neural Networks via Attention Transfercited by 1,059
  4. 2016SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <0.5MB model sizecited by 1,054
  5. 2019Relational Knowledge Distillationcited by 873
  6. 2019Contrastive Representation Distillationcited by 734
  7. 2019UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentationcited by 583
  8. 2019Similarity-Preserving Knowledge Distillationcited by 507
  9. 2019The Liver Tumor Segmentation Benchmark (LiTS)cited by 504
  10. 2019Be Your Own Teacher: Improve the Performance of Convolutional Neural Networks via Self Distillationcited by 491
  11. 2016ENet: A Deep Neural Network Architecture for Real-Time Semantic Segmentationcited by 291
  12. 2018nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentationcited by 291
  13. 2019Structured Knowledge Distillation for Dense Predictioncited by 277
  14. 2019The KiTS19 Challenge Data: 300 Kidney Tumor Cases with Clinical Context, CT Semantic Segmentations, and Surgical Outcomescited by 168
  15. 2018ESPNet: Efficient Spatial Pyramid of Dilated Convolutions for Semantic Segmentationcited by 133
  16. 2019Knowledge Adaptation for Efficient Semantic Segmentationcited by 105
  17. 2020Hi-Net: Hybrid-fusion Network for Multi-modal MR Image Synthesiscited by 86
  18. 2020Unpaired Multi-modal Segmentation via Knowledge Distillationcited by 81
  19. 2020SA-UNet: Spatial Attention U-Net for Retinal Vessel Segmentationcited by 70
  20. 2018SynSeg-Net: Synthetic Segmentation Without Target Modality Ground Truthcited by 68
  21. 2021Knowledge distillation from multi-modal to mono-modal segmentation networkscited by 68
  22. 2016Automatic Liver and Lesion Segmentation in CT Using Cascaded Fully Convolutional Neural Networks and 3D Conditional Random Fieldscited by 43
  23. 2018RA-UNet: A hybrid deep attention-aware network to extract liver and tumor in CT scanscited by 41
  24. 2020Towards Cross-modality Medical Image Segmentation with Online Mutual Knowledge Distillationcited by 38
  25. 2018Improving Fast Segmentation With Teacher-student Learningcited by 34
  26. 2019Recurrent U-Net for Resource-Constrained Segmentationcited by 27
  27. 2017Liver lesion segmentation informed by joint liver segmentationcited by 18
  28. 2016Automatic 3D liver location and segmentation via convolutional neural networks and graph cutcited by 15
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  30. 2016Do Deep Convolutional Nets Really Need to be Deep and Convolutional?cited by 8

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2022: 10; 2023: 8; 2024: 13; 2025: 8; 2026: 4.

43 papers.

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  1. 2023Large AI Models in Health Informatics: Applications, Challenges, and the Futurecited by 61
  2. 2023Knowledge Distillation on Graphs: A Surveycited by 38
  3. 2022SSD-KD: A Self-supervised Diverse Knowledge Distillation Method for Lightweight Skin Lesion Classification Using Dermoscopic Imagescited by 11
  4. 2026ReCo-KD: Region- and Context-Aware Knowledge Distillation for Efficient 3D Medical Image Segmentationcited by 10
  5. 2022Graph Flow: Cross-layer Graph Flow Distillation for Dual Efficient Medical Image Segmentationcited by 7
  6. 2022MISSU: 3D Medical Image Segmentation via Self-distilling TransUNetcited by 7
  7. 2024Test-time generative augmentation for medical image segmentationcited by 6
  8. 2023Dice Semimetric Losses: Optimizing the Dice Score with Soft Labelscited by 5
  9. 2024Detecting Wildfires on UAVs with Real-time Segmentation Trained by Larger Teacher Modelscited by 5
  10. 2025No More Sliding Window: Efficient 3D Medical Image Segmentation with Differentiable Top-k Patch Samplingcited by 5
  11. 2022Topology-Preserving Segmentation Network: A Deep Learning Segmentation Framework for Connected Componentcited by 4
  12. 2022Med-DANet: Dynamic Architecture Network for Efficient Medical Volumetric Segmentationcited by 4
31 more
  1. 2022SlimSeg: Slimmable Semantic Segmentation with Boundary Supervisioncited by 4
  2. 2024Shape-intensity knowledge distillation for robust medical image segmentationcited by 4
  3. 2022Knowledge Distillation approach towards Melanoma Detectioncited by 3
  4. 2023LumiNet: Perception-Driven Knowledge Distillation via Statistical Logit Calibrationcited by 3
  5. 2022Exploring Generalizable Distillation for Efficient Medical Image Segmentationcited by 2
  6. 2023Volumetric medical image segmentation through dual self-distillation in U-shaped networkscited by 2
  7. 2023Rethinking Intermediate Layers design in Knowledge Distillation for Kidney and Liver Tumor Segmentationcited by 2
  8. 2024Weakly Supervised Change Detection via Knowledge Distillation and Multiscale Sigmoid Inferencecited by 2
  9. 2024Enhancing Single-Slice Segmentation with 3D-to-2D Unpaired Scan Distillationcited by 2
  10. 2024DSG-KD: Knowledge Distillation from Domain-Specific to General Language Modelscited by 2
  11. 2025Digital Staining with Knowledge Distillation: A Unified Framework for Unpaired and Paired-But-Misaligned Datacited by 2
  12. 2024Graph Relation Distillation for Efficient Biomedical Instance Segmentationcited by 1
  13. 2024Computer Vision Model Compression Techniques for Embedded Systems: A Surveycited by 1
  14. 2025DCSNet: A Lightweight Knowledge Distillation-Based Model with Explainable AI for Lung Cancer Diagnosis from Histopathological Imagescited by 1
  15. 2025RankSEG-RMA: An Efficient Segmentation Algorithm via Reciprocal Moment Approximationcited by 1
  16. 2026Multi-AD: Cross-Domain Unsupervised Anomaly Detection for Medical and Industrial Applicationscited by 1
  17. 2026Displacement Preserving Relational Distillation for Robust Medical Segmentationcited by 1
  18. 2022Knowledge Distillation from Cross Teaching Teachers for Efficient Semi-Supervised Abdominal Organ Segmentation in CTcited by 0
  19. 2022Leveraging Different Learning Styles for Improved Knowledge Distillation in Biomedical Imagingcited by 0
  20. 2023Knowledge Distillation for Adaptive MRI Prostate Segmentation Based on Limit-Trained Multi-Teacher Modelscited by 0
  21. 2023Sculpting Efficiency: Pruning Medical Imaging Models for On-Device Inferencecited by 0
  22. 2024Transferring Ultrahigh-Field Representations for Intensity-Guided Brain Segmentation of Low-Field Magnetic Resonance Imagingcited by 0
  23. 2024MedContext: Learning Contextual Cues for Efficient Volumetric Medical Segmentationcited by 0
  24. 2024Adaptive Affinity-Based Generalization For MRI Imaging Segmentation Across Resource-Limited Settingscited by 0
  25. 2024Exploring Graph-based Knowledge: Multi-Level Feature Distillation via Channels Relational Graphcited by 0
  26. 2024FedBrain-Distill: Communication-Efficient Federated Brain Tumor Classification Using Ensemble Knowledge Distillation on Non-IID Datacited by 0
  27. 2025Opening the black box of deep learning: Validating the statistical association between explainable artificial intelligence (XAI) and clinical domain knowledge in fundus image-based glaucoma diagnosiscited by 0
  28. 2025VLCD: Vision-Language Contrastive Distillation for Accurate and Efficient Automatic Placenta Analysiscited by 0
  29. 2025TOM: An Open-Source Tongue Segmentation Method with Multi-Teacher Distillation and Task-Specific Data Augmentationcited by 0
  30. 2025WeCKD: Weakly-supervised Chained Distillation Network for Efficient Multimodal Medical Imagingcited by 0
  31. 2026DiffSegLung: Diffusion Radiomic Distillation for Unsupervised Lung Pathology Segmentationcited by 0