Graph Relation Distillation for Efficient Biomedical Instance Segmentation

Instance-aware embeddings predicted by deep neural networks have revolutionized biomedical instance segmentation, but its resource requirements are substantial. Knowledge distillation offers a solution by transferring distilled knowledge from heavy teacher networks to lightweight yet high-performance student networks. However, existing knowledge distillation methods struggle to extract knowledge for distinguishing instances and overlook global relation information. To address these challenges, we propose a graph relation distillation approach for efficient biomedical instance segmentation, which considers three essential types of knowledge: instance-level features, instance relations, and pixel-level boundaries. We introduce two graph distillation schemes deployed at both the intra-image level and the inter-image level: instance graph distillation (IGD) and affinity graph distillation (AGD). IGD constructs a graph representing instance features and relations, transferring these two types of knowledge by enforcing instance graph consistency. AGD constructs an affinity graph representing pixel relations to capture structured knowledge of instance boundaries, transferring boundary-related knowledge by ensuring pixel affinity consistency. Experimental results on a number of biomedical datasets validate the effectiveness of our approach, enabling student models with less than 1% parameters and less than 10% inference time while achieving promising performance compared to teacher models.