Large Deformation Diffeomorphic Image Registration with Laplacian Pyramid Networks
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Abstract (arXiv)
Deep learning-based methods have recently demonstrated promising results in deformable image registration for a wide range of medical image analysis tasks. However, existing deep learning-based methods are usually limited to small deformation settings, and desirable properties of the transformation including bijective mapping and topology preservation are often being ignored by these approaches. In this paper, we propose a deep Laplacian Pyramid Image Registration Network, which can solve the image registration optimization problem in a coarse-to-fine fashion within the space of diffeomorphic maps. Extensive quantitative and qualitative evaluations on two MR brain scan datasets show that our method outperforms the existing methods by a significant margin while maintaining desirable diffeomorphic properties and promising registration speed.
Key facts. Cited by 136 papers in the map (data through 13 Oct 2026). First posted on arXiv 29 Jun 2020.
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Citing papers per year: 2021: 8; 2022: 23; 2023: 28; 2024: 37; 2025: 26; 2026: 14.
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- 2021Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learningcited by 125
- 2021Conditional Deformable Image Registration with Convolutional Neural Networkcited by 59
- 2023A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyondcited by 55
- 2024uniGradICON: A Foundation Model for Medical Image Registrationcited by 55
- 2022textttGradICON: Approximate Diffeomorphisms via Gradient Inverse Consistencycited by 40
- 2024Correlation-aware Coarse-to-fine MLPs for Deformable Medical Image Registrationcited by 37
- 2022Affine Medical Image Registration with Coarse-to-Fine Vision Transformercited by 35
- 2022Learning the Effect of Registration Hyperparameters with HyperMorphcited by 35
- 2022Fourier-Net: Fast Image Registration with Band-limited Deformationcited by 22
- 2022Learning Whole Heart Mesh Generation From Patient Images For Computational Simulationscited by 21
- 2023Non-iterative Coarse-to-fine Transformer Networks for Joint Affine and Deformable Image Registrationcited by 21
- 2022Diffeomorphic Image Registration with Neural Velocity Fieldcited by 20
38 more
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- 2023FSDiffReg: Feature-wise and Score-wise Diffusion-guided Unsupervised Deformable Image Registration for Cardiac Imagescited by 18
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- 2021Test-Time Training for Deformable Multi-Scale Image Registrationcited by 17
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- 2022Unsupervised Deformable Image Registration with Absent Correspondences in Pre-operative and Post-Recurrence Brain Tumor MRI Scanscited by 15
- 2023SAMConvex: Fast Discrete Optimization for CT Registration using Self-supervised Anatomical Embedding and Correlation Pyramidcited by 14
- 2024MemWarp: Discontinuity-Preserving Cardiac Registration with Memorized Anatomical Filterscited by 13
- 2021Enhancing Medical Image Registration via Appearance Adjustment Networkscited by 12
- 2023Inverse Consistency by Construction for Multistep Deep Registrationcited by 12
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- 2021Deep learning based geometric registration for medical images: How accurate can we get without visual features?cited by 10
- 2022Brain Tumor Sequence Registration with Non-iterative Coarse-to-fine Networks and Dual Deep Supervisioncited by 10
- 2024Vector Field Attention for Deformable Image Registrationcited by 10
- 2022Robust Image Registration with Absent Correspondences in Pre-operative and Follow-up Brain MRI Scans of Diffuse Glioma Patientscited by 9
- 2023Deformable Cross-Attention Transformer for Medical Image Registrationcited by 9
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- 2023SITReg: Multi-resolution architecture for symmetric, inverse consistent, and topology preserving image registrationcited by 7
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- 2024RegWSI: Whole Slide Image Registration using Combined Deep Feature- and Intensity-Based Methods: Winner of the ACROBAT 2023 Challengecited by 7
- 2021Recursive Refinement Network for Deformable Lung Registration between Exhale and Inhale CT Scanscited by 6
- 2024DiffuseReg: Denoising Diffusion Model for Obtaining Deformation Fields in Unsupervised Deformable Image Registrationcited by 6
- 2025Improving Generalization of Medical Image Registration Foundation Modelcited by 6
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- 2023Conditional Deformable Image Registration with Spatially-Variant and Adaptive Regularizationcited by 5
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- 2022Learning deep abdominal CT registration through adaptive loss weighting and synthetic data generationcited by 4
- 2023A Hierarchical Descriptor Framework for On-the-Fly Anatomical Location Matching between Longitudinal Studiescited by 4
50 most cited of 136 All 136 (JSON)
- 2026Recursive Uncertainty-Gated Image Registration for Learning-based Algorithms23 Sep 2026
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- 2026Architectural and Regularization Components in Deep Learning Medical Image Registration: Systematic Ablation Study23 Aug 2026
- 2026An Accessible Solution for Deformable Image Registration Compared with Learning-Based Approaches3 Aug 2026
- 2026SpikeReg: Energy-Efficient 3D Deformable Medical Image Registration with Spiking Neural Networks24 May 2026
- 2026A Multimodal Clinically Informed Coarse-to-Fine Framework for Longitudinal CT Registration in Proton Therapy15 Apr 2026
- 2026CoRe: Joint Optimization with Contrastive Learning for Medical Image Registration24 Mar 2026
- 2026Polaffini: A feature-based approach for robust affine and polyaffine image registration19 Feb 2026
- 2026Deformation-Free Cross-Domain Image Registration via Position-Encoded Temporal Attention17 Feb 2026
- 2026PCReg-Net: Progressive Contrast-Guided Registration for Cross-Domain Image Alignment9 Feb 2026
38 more
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- 2025Disentangling Progress in Medical Image Registration: Beyond Trend-Driven Architectures towards Domain-Specific Strategies1 Dec 2025
- 2025MorphSeek: Fine-grained Latent Representation-Level Policy Optimization for Deformable Image Registration21 Nov 2025
- 2025Efficient Large-Deformation Medical Image Registration via Recurrent Dynamic Correlation25 Oct 2025
- 2025A Scalable Distributed Framework for Multimodal GigaVoxel Image Registration29 Sep 2025
- 2025Uncertainty Estimation for Pretrained Medical Image Registration Models via Transformation Equivariance27 Sep 2025
- 2025Deformable Medical Image Registration with KAN-based Implicit Neural Representations26 Sep 2025
- 2025SHMoAReg: Spark Deformable Image Registration via Spatial Heterogeneous Mixture of Experts and Attention Heads24 Sep 2025
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- 2025SAMIR, an efficient registration framework via robust feature learning from SAM17 Sep 2025
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- 2025Deep Biomechanically-Guided Interpolation for Keypoint-Based Brain Shift Registration19 Aug 2025
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- 2025TotalRegistrator: Towards a Lightweight Foundation Model for CT Image Registration6 Aug 2025
- 2025Modality-Aware Feature Matching in Visual and Vision-Language Applications: A Comprehensive Survey30 Jul 2025
- 2025Bridging Classical and Learning-based Iterative Registration through Deep Equilibrium Models1 Jul 2025
- 2025Deformable Medical Image Registration with Effective Anatomical Structure Representation and Divide-and-Conquer Network24 Jun 2025
- 2025Unsupervised Deformable Image Registration with Structural Nonparametric Smoothing12 Jun 2025
- 2025Implicit Deformable Medical Image Registration with Learnable Kernels2 Jun 2025
- 2025Improving Generalization of Medical Image Registration Foundation Model10 May 2025
- 2025Unwarping Screen Content Images via Structure-texture Enhancement Network and Transformation Self-estimation21 Apr 2025
- 2025Biomechanical Constraints Assimilation in Deep-Learning Image Registration: Application to sliding and locally rigid deformations7 Apr 2025
- 2025SACB-Net: Spatial-awareness Convolutions for Medical Image Registration25 Mar 2025
- 2025UniReg: Conditional Unified Model for Medical Image Registration17 Mar 2025
- 2025Reference-Free 3D Reconstruction of Brain Dissection Slabs via Learned Atlas Coordinates13 Mar 2025
- 2025Evaluation of Deformable Image Registration under Alignment-Regularity Trade-off10 Mar 2025
- 2025TimeFlow: Temporal Conditioning for Longitudinal Brain MRI Registration and Aging Analysis15 Jan 2025
- 2024Advancing Deformable Medical Image Registration with Multi-axis Cross-covariance Attention24 Dec 2024
- 2024PointVoxelFormer -- Reviving point cloud networks for 3D medical imaging23 Dec 2024
- 2024Interpretable deformable image registration: A geometric deep learning perspective17 Dec 2024
- 2024LDM-Morph: Latent diffusion model guided deformable image registration23 Nov 2024
- 2024UTSRMorph: A Unified Transformer and Superresolution Network for Unsupervised Medical Image Registration27 Oct 2024
- 2024Stationary Velocity Fields on Matrix Groups for Deformable Image Registration14 Oct 2024
- 2024DiffuseReg: Denoising Diffusion Model for Obtaining Deformation Fields in Unsupervised Deformable Image Registration7 Oct 2024
- 2024Dual-Attention Frequency Fusion at Multi-Scale for Joint Segmentation and Deformable Medical Image Registration29 Sep 2024
- 2024Tumor aware recurrent inter-patient deformable image registration of computed tomography scans with lung cancer18 Sep 2024
- 2024Quantifying Knee Cartilage Shape and Lesion: From Image to Metrics11 Sep 2024
50 newest of 136 All 136 (JSON)
- 2023FSDiffReg: Feature-wise and Score-wise Diffusion-guided Unsupervised Deformable Image Registration for Cardiac Imagescited by 18
- 2024DiffuseReg: Denoising Diffusion Model for Obtaining Deformation Fields in Unsupervised Deformable Image Registrationcited by 6
- 2024LDM-Morph: Latent diffusion model guided deformable image registrationcited by 0
- 2024LDM-Morph: Latent diffusion model guided deformable image registration23 Nov 2024
- 2024DiffuseReg: Denoising Diffusion Model for Obtaining Deformation Fields in Unsupervised Deformable Image Registration7 Oct 2024
- 2023FSDiffReg: Feature-wise and Score-wise Diffusion-guided Unsupervised Deformable Image Registration for Cardiac Images22 Jul 2023
- 2021Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learningcited by 125
- 2021Conditional Deformable Image Registration with Convolutional Neural Networkcited by 59
- 2023A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyondcited by 55
- 2024uniGradICON: A Foundation Model for Medical Image Registrationcited by 55
- 2022textttGradICON: Approximate Diffeomorphisms via Gradient Inverse Consistencycited by 40
- 2024Correlation-aware Coarse-to-fine MLPs for Deformable Medical Image Registrationcited by 37
- 2022Affine Medical Image Registration with Coarse-to-Fine Vision Transformercited by 35
- 2022Learning the Effect of Registration Hyperparameters with HyperMorphcited by 35
- 2022Fourier-Net: Fast Image Registration with Band-limited Deformationcited by 22
- 2022Learning Whole Heart Mesh Generation From Patient Images For Computational Simulationscited by 21
- 2023Non-iterative Coarse-to-fine Transformer Networks for Joint Affine and Deformable Image Registrationcited by 21
- 2022Diffeomorphic Image Registration with Neural Velocity Fieldcited by 20
12 most cited of 132 All 132 (JSON)
- 2026Recursive Uncertainty-Gated Image Registration for Learning-based Algorithms23 Sep 2026
- 2026Fast and Accurate Monomodal 3D High Resolution Deep Registration of Drosophila Larval Brain Volumes10 Sep 2026
- 2026Two-Parameter Flow Map Learning for Continuous-Time Diffeomorphic Image Registration9 Sep 2026
- 2026SynthRCT: Scalable Conditional Deformation Synthesis for Synthetic Repeat CT Generation8 Sep 2026
- 2026Architectural and Regularization Components in Deep Learning Medical Image Registration: Systematic Ablation Study23 Aug 2026
- 2026An Accessible Solution for Deformable Image Registration Compared with Learning-Based Approaches3 Aug 2026
- 2026SpikeReg: Energy-Efficient 3D Deformable Medical Image Registration with Spiking Neural Networks24 May 2026
- 2026A Multimodal Clinically Informed Coarse-to-Fine Framework for Longitudinal CT Registration in Proton Therapy15 Apr 2026
- 2026CoRe: Joint Optimization with Contrastive Learning for Medical Image Registration24 Mar 2026
- 2026Polaffini: A feature-based approach for robust affine and polyaffine image registration19 Feb 2026
- 2026Deformation-Free Cross-Domain Image Registration via Position-Encoded Temporal Attention17 Feb 2026
- 2026PCReg-Net: Progressive Contrast-Guided Registration for Cross-Domain Image Alignment9 Feb 2026
12 newest of 132 All 132 (JSON)