mlsanityData to 7 Oct 2026

Deep Learning in Medical Image Registration: A Survey

arXiv 1903.02026 ↗First posted 5 Mar 2019q-bio.QM cs.CV eess.IVcited by 124

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Abstract (arXiv)

The establishment of image correspondence through robust image registration is critical to many clinical tasks such as image fusion, organ atlas creation, and tumor growth monitoring, and is a very challenging problem. Since the beginning of the recent deep learning renaissance, the medical imaging research community has developed deep learning based approaches and achieved the state-of-the-art in many applications, including image registration. The rapid adoption of deep learning for image registration applications over the past few years necessitates a comprehensive summary and outlook, which is the main scope of this survey. This requires placing a focus on the different research areas as well as highlighting challenges that practitioners face. This survey, therefore, outlines the evolution of deep learning based medical image registration in the context of both research challenges and relevant innovations in the past few years. Further, this survey highlights future research directions to show how this field may be possibly moved forward to the next level.

Key facts. Cited by 124 papers in the map (data through 7 Oct 2026). First posted on arXiv 5 Mar 2019.

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Citing papers per year: 2021: 21; 2022: 27; 2023: 28; 2024: 25; 2025: 12; 2026: 11.

124 papers.

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  1. 2022Transformers in Medical Imaging: A Surveycited by 245
  2. 2021Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learningcited by 125
  3. 2021Recent advances and clinical applications of deep learning in medical image analysiscited by 104
  4. 2023Advances in Medical Image Analysis with Vision Transformers: A Comprehensive Reviewcited by 62
  5. 2024Correlation-aware Coarse-to-fine MLPs for Deformable Medical Image Registrationcited by 37
  6. 2023Geometric Visual Similarity Learning in 3D Medical Image Self-supervised Pre-trainingcited by 36
  7. 2024Local Feature Matching Using Deep Learning: A Surveycited by 26
  8. 2022A Survey on Training Challenges in Generative Adversarial Networks for Biomedical Image Analysiscited by 24
  9. 2021The Impact of Machine Learning on 2D/3D Registration for Image-guided Interventions: A Systematic Review and Perspectivecited by 22
  10. 2022Generative Myocardial Motion Tracking via Latent Space Exploration with Biomechanics-informed Priorcited by 22
  11. 2021Cross-modal Attention for MRI and Ultrasound Volume Registrationcited by 21
  12. 2021Imbalanced Big Data Oversampling: Taxonomy, Algorithms, Software, Guidelines and Future Directionscited by 21
38 more
  1. 2023Non-iterative Coarse-to-fine Transformer Networks for Joint Affine and Deformable Image Registrationcited by 21
  2. 2022Non-iterative Coarse-to-fine Registration based on Single-pass Deep Cumulative Learningcited by 20
  3. 2024Deep Learning in Medical Image Registration: Magic or Mirage?cited by 20
  4. 2022A Review of Causality for Learning Algorithms in Medical Image Analysiscited by 18
  5. 2023Deep Learning for Retrospective Motion Correction in MRI: A Comprehensive Reviewcited by 18
  6. 2023Spatially Covariant Image Registration with Text Promptscited by 18
  7. 2021Test-Time Training for Deformable Multi-Scale Image Registrationcited by 17
  8. 2023Transformers in Healthcare: A Surveycited by 17
  9. 2023Robust deformable image registration using cycle-consistent implicit representationscited by 13
  10. 2021Enhancing Medical Image Registration via Appearance Adjustment Networkscited by 12
  11. 2021Comparison of Consecutive and Re-stained Sections for Image Registration in Histopathologycited by 12
  12. 2022Self-Supervised 2D/3D Registration for X-Ray to CT Image Fusioncited by 12
  13. 2023Is attention all you need in medical image analysis? A reviewcited by 12
  14. 2024General Purpose Image Encoder DINOv2 for Medical Image Registrationcited by 11
  15. 2022Brain Tumor Sequence Registration with Non-iterative Coarse-to-fine Networks and Dual Deep Supervisioncited by 10
  16. 2025From Screens to Scenes: A Survey of Embodied AI in Healthcarecited by 10
  17. 2021Is Image-to-Image Translation the Panacea for Multimodal Image Registration? A Comparative Studycited by 9
  18. 2021Unsupervised Landmark Detection Based Spatiotemporal Motion Estimation for 4D Dynamic Medical Imagescited by 9
  19. 2022Cross-Modality Multi-Atlas Segmentation via Deep Registration and Label Fusioncited by 8
  20. 2022Deep Learning for Medical Image Registration: A Comprehensive Reviewcited by 8
  21. 2023Non-rigid Medical Image Registration using Physics-informed Neural Networkscited by 8
  22. 2025Synthetic CT image generation from CBCT: A Systematic Reviewcited by 8
  23. 2022Prior Knowledge-Guided Attention in Self-Supervised Vision Transformerscited by 7
  24. 2023Unsupervised 3D registration through optimization-guided cyclical self-trainingcited by 7
  25. 2024RegWSI: Whole Slide Image Registration using Combined Deep Feature- and Intensity-Based Methods: Winner of the ACROBAT 2023 Challengecited by 7
  26. 2024Epicardium Prompt-guided Real-time Cardiac Ultrasound Frame-to-volume Registrationcited by 7
  27. 2021Fast computation of mutual information in the frequency domain with applications to global multimodal image alignmentcited by 6
  28. 2022Weakly-supervised Biomechanically-constrained CT/MRI Registration of the Spinecited by 6
  29. 2023AutoFuse: Automatic Fusion Networks for Deformable Medical Image Registrationcited by 6
  30. 2023Full-resolution MLPs Empower Medical Dense Predictioncited by 6
  31. 2021Stochastic Planner-Actor-Critic for Unsupervised Deformable Image Registrationcited by 5
  32. 2022Adapting the Mean Teacher for keypoint-based lung registration under geometric domain shiftscited by 5
  33. 2022Medical image registration using unsupervised deep neural network: A scoping literature reviewcited by 5
  34. 2024Deep Implicit Optimization enables Robust Learnable Features for Deformable Image Registrationcited by 5
  35. 2021Cascaded Feature Warping Network for Unsupervised Medical Image Registrationcited by 4
  36. 2021MICS : Multi-steps, Inverse Consistency and Symmetric deep learning registration networkcited by 4
  37. 2022A Sub-pixel Accurate Quantification of Joint Space Narrowing Progression in Rheumatoid Arthritiscited by 4
  38. 2022Meta-Learning Initializations for Interactive Medical Image Registrationcited by 4

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