mlsanityData to 7 Oct 2026

GAMENet: Graph Augmented MEmory Networks for Recommending Medication Combination

arXiv 1809.01852 ↗First posted 6 Sep 2018cs.AI cs.LG stat.MLcited by 79

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Abstract (arXiv)

Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing approaches either do not customize based on patient health history, or ignore existing knowledge on drug-drug interactions (DDI) that might lead to adverse outcomes. To fill this gap, we propose the Graph Augmented Memory Networks (GAMENet), which integrates the drug-drug interactions knowledge graph by a memory module implemented as a graph convolutional networks, and models longitudinal patient records as the query. It is trained end-to-end to provide safe and personalized recommendation of medication combination. We demonstrate the effectiveness and safety of GAMENet by comparing with several state-of-the-art methods on real EHR data. GAMENet outperformed all baselines in all effectiveness measures, and also achieved 3.60% DDI rate reduction from existing EHR data.

Key facts. Cited by 79 papers in the map (data through 7 Oct 2026). First posted on arXiv 6 Sep 2018.

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Citing papers per year: 2021: 8; 2022: 11; 2023: 16; 2024: 13; 2025: 17; 2026: 14.

79 papers.

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  1. 2021Graph Representation Learning in Biomedicinecited by 79
  2. 2023GraphCare: Enhancing Healthcare Predictions with Personalized Knowledge Graphscited by 57
  3. 2021SafeDrug: Dual Molecular Graph Encoders for Recommending Effective and Safe Drug Combinationscited by 51
  4. 2021Change Matters: Medication Change Prediction with Recurrent Residual Networkscited by 37
  5. 2021Heterogeneous Similarity Graph Neural Network on Electronic Health Recordscited by 29
  6. 2022Conditional Generation Net for Medication Recommendationcited by 28
  7. 2021How to Leverage Multimodal EHR Data for Better Medical Predictions?cited by 26
  8. 2024Large Language Model Distilling Medication Recommendation Modelcited by 25
  9. 2023ManyDG: Many-domain Generalization for Healthcare Applicationscited by 23
  10. 2023A Review on Knowledge Graphs for Healthcare: Resources, Applications, and Promisescited by 13
  11. 2022DialMed: A Dataset for Dialogue-based Medication Recommendationcited by 12
  12. 2022Old can be Gold: Better Gradient Flow can Make Vanilla-GCNs Great Againcited by 11
38 more
  1. 2024Leave No Patient Behind: Enhancing Medication Recommendation for Rare Disease Patientscited by 11
  2. 2024Rethinking Fair Graph Neural Networks from Re-balancingcited by 11
  3. 2023Synthesize High-dimensional Longitudinal Electronic Health Records via Hierarchical Autoregressive Language Modelcited by 8
  4. 2022Enabling Homogeneous GNNs to Handle Heterogeneous Graphs via Relation Embeddingcited by 7
  5. 2023SHAPE: A Sample-adaptive Hierarchical Prediction Network for Medication Recommendationcited by 7
  6. 2024CausalMed: Causality-Based Personalized Medication Recommendation Centered on Patient health statecited by 7
  7. 2021Knowledge Grounded Conversational Symptom Detection with Graph Memory Networkscited by 6
  8. 2023StratMed: Relevance Stratification between Biomedical Entities for Sparsity on Medication Recommendationcited by 6
  9. 2023VITA: 'Carefully Chosen and Weighted Less' Is Better in Medication Recommendationcited by 6
  10. 2023Collaborative Synthesis of Patient Records through Multi-Visit Health State Inferencecited by 6
  11. 2024Contrastive Learning on Medical Intents for Sequential Prescription Recommendationcited by 6
  12. 2024RareAgents: Autonomous Multi-disciplinary Team for Rare Disease Diagnosis and Treatmentcited by 6
  13. 2025Biomedical Knowledge Graph: A Survey of Domains, Tasks, and Real-World Applicationscited by 6
  14. 2026EHR-RAG: Bridging Long-Horizon Structured Electronic Health Records and Large Language Models via Enhanced Retrieval-Augmented Generationcited by 6
  15. 2021MeSIN: Multilevel Selective and Interactive Network for Medication Recommendationcited by 5
  16. 2022Label Dependent Attention Model for Disease Risk Prediction Using Multimodal Electronic Health Recordscited by 5
  17. 2023Out-of-Distribution Generalized Dynamic Graph Neural Network for Human Albumin Predictioncited by 5
  18. 2024L^2GC:Lorentzian Linear Graph Convolutional Networks for Node Classificationcited by 5
  19. 2025Unveiling Discrete Clues: Superior Healthcare Predictions for Rare Diseasescited by 5
  20. 2025Fine-grained List-wise Alignment for Generative Medication Recommendationcited by 5
  21. 2026Towards a Medical AI Scientistcited by 5
  22. 2022Binary Graph Convolutional Network with Capacity Explorationcited by 4
  23. 2025Natural Language-Assisted Multi-modal Medication Recommendationcited by 4
  24. 2024Automated Fusion of Multimodal Electronic Health Records for Better Medical Predictionscited by 3
  25. 2024CIDGMed: Causal Inference-Driven Medication Recommendation with Enhanced Dual-Granularity Learningcited by 3
  26. 2025Discovering Hierarchy-Grounded Domains with Adaptive Granularity for Clinical Domain Generalizationcited by 3
  27. 2026HypeMed: Enhancing Medication Recommendations with Hypergraph-Based Patient Relationshipscited by 3
  28. 2022AutoMap: Automatic Medical Code Mapping for Clinical Prediction Model Deploymentcited by 2
  29. 2022Knowledge-Driven New Drug Recommendationcited by 2
  30. 2023Clinical Note Owns its Hierarchy: Multi-Level Hypergraph Neural Networks for Patient-Level Representation Learningcited by 2
  31. 2023Sequential Condition Evolved Interaction Knowledge Graph for Traditional Chinese Medicine Recommendationcited by 2
  32. 2024OntoMedRec: Logically-Pretrained Model-Agnostic Ontology Encoders for Medication Recommendationcited by 2
  33. 2025ProtoEHR: Hierarchical Prototype Learning for EHR-based Healthcare Predictionscited by 2
  34. 2021Classification of hierarchical text using geometric deep learning: the case of clinical trials corpuscited by 1
  35. 2022GPNet: Simplifying Graph Neural Networks via Multi-channel Geometric Polynomialscited by 1
  36. 2023Graph Representation Learning for Interactive Biomolecule Systemscited by 1
  37. 2023DKINet: Medication Recommendation via Domain Knowledge Informed Deep Learningcited by 1
  38. 2023ACDNet: Attention-guided Collaborative Decision Network for Effective Medication Recommendationcited by 1

50 most cited of 79 All 79 (JSON)