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Revisiting Multiple Instance Neural Networks

arXiv 1610.02501 ↗First posted 8 Oct 2016stat.ML cs.LGcited by 119

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Abstract (arXiv)

Recently neural networks and multiple instance learning are both attractive topics in Artificial Intelligence related research fields. Deep neural networks have achieved great success in supervised learning problems, and multiple instance learning as a typical weakly-supervised learning method is effective for many applications in computer vision, biometrics, nature language processing, etc. In this paper, we revisit the problem of solving multiple instance learning problems using neural networks. Neural networks are appealing for solving multiple instance learning problem. The multiple instance neural networks perform multiple instance learning in an end-to-end way, which take a bag with various number of instances as input and directly output bag label. All of the parameters in a multiple instance network are able to be optimized via back-propagation. We propose a new multiple instance neural network to learn bag representations, which is different from the existing multiple instance neural networks that focus on estimating instance label. In addition, recent tricks developed in deep learning have been studied in multiple instance networks, we find deep supervision is effective for boosting bag classification accuracy. In the experiments, the proposed multiple instance networks achieve state-of-the-art or competitive performance on several MIL benchmarks. Moreover, it is extremely fast for both testing and training, e.g., it takes only 0.0003 second to predict a bag and a few seconds to train on a MIL datasets on a moderate CPU.

Key facts. Cited by 119 papers in the map (data through 7 Oct 2026). First posted on arXiv 8 Oct 2016.

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Citing papers per year: 2021: 15; 2022: 26; 2023: 36; 2024: 19; 2025: 15; 2026: 8.

119 papers.

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  1. 2021TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classificationcited by 549
  2. 2022DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classificationcited by 254
  3. 2022Catching Both Gray and Black Swans: Open-set Supervised Anomaly Detectioncited by 104
  4. 2023Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Imagescited by 91
  5. 2023Dual Memory Units with Uncertainty Regulation for Weakly Supervised Video Anomaly Detectioncited by 88
  6. 2021Weakly Supervised Object Localization and Detection: A Surveycited by 84
  7. 2021Explainable Deep Few-shot Anomaly Detection with Deviation Networkscited by 69
  8. 2023Multiple Instance Learning Framework with Masked Hard Instance Mining for Whole Slide Image Classificationcited by 58
  9. 2022Bi-directional Weakly Supervised Knowledge Distillation for Whole Slide Image Classificationcited by 42
  10. 2022Towards Label-efficient Automatic Diagnosis and Analysis: A Comprehensive Survey of Advanced Deep Learning-based Weakly-supervised, Semi-supervised and Self-supervised Techniques in Histopathological Image Analysiscited by 29
  11. 2023Diagnose Like a Pathologist: Transformer-Enabled Hierarchical Attention-Guided Multiple Instance Learning for Whole Slide Image Classificationcited by 27
  12. 2024Generalizable Whole Slide Image Classification with Fine-Grained Visual-Semantic Interactioncited by 27
38 more
  1. 2024DGR-MIL: Exploring Diverse Global Representation in Multiple Instance Learning for Whole Slide Image Classificationcited by 25
  2. 2023Inherently Interpretable Time Series Classification via Multiple Instance Learningcited by 23
  3. 2021ProtoMIL: Multiple Instance Learning with Prototypical Parts for Whole-Slide Image Classificationcited by 22
  4. 2023Rethinking Multiple Instance Learning for Whole Slide Image Classification: A Good Instance Classifier is All You Needcited by 21
  5. 2022Multi-Instance Causal Representation Learning for Instance Label Prediction and Out-of-Distribution Generalizationcited by 17
  6. 2021Label Cleaning Multiple Instance Learning: Refining Coarse Annotations on Single Whole-Slide Imagescited by 13
  7. 2022Interventional Multi-Instance Learning with Deconfounded Instance-Level Predictioncited by 13
  8. 2022Non-Markovian Reward Modelling from Trajectory Labels via Interpretable Multiple Instance Learningcited by 13
  9. 2023CAMIL: Context-Aware Multiple Instance Learning for Cancer Detection and Subtyping in Whole Slide Imagescited by 13
  10. 2024TimeMIL: Advancing Multivariate Time Series Classification via a Time-aware Multiple Instance Learningcited by 12
  11. 2023Reproducibility in Multiple Instance Learning: A Case For Algorithmic Unit Testscited by 11
  12. 2024Agent Aggregator with Mask Denoise Mechanism for Histopathology Whole Slide Image Analysiscited by 11
  13. 2022Model Agnostic Interpretability for Multiple Instance Learningcited by 10
  14. 2022DSCA: A Dual-Stream Network with Cross-Attention on Whole-Slide Image Pyramids for Cancer Prognosiscited by 10
  15. 2023Disambiguated Attention Embedding for Multi-Instance Partial-Label Learningcited by 9
  16. 2023A Unified Approach to Count-Based Weakly-Supervised Learningcited by 9
  17. 2023Probabilistic Attention based on Gaussian Processes for Deep Multiple Instance Learningcited by 8
  18. 2022EGFR Mutation Prediction of Lung Biopsy Images using Deep Learningcited by 7
  19. 2023Detecting Heart Disease from Multi-View Ultrasound Images via Supervised Attention Multiple Instance Learningcited by 7
  20. 2024From Correlation to Causation: Max-Pooling-Based Multi-Instance Learning Leads to More Robust Whole Slide Image Classificationcited by 7
  21. 2024MergeUp-augmented Semi-Weakly Supervised Learning for WSI Classificationcited by 7
  22. 2024Ordinal Multiple-instance Learning for Ulcerative Colitis Severity Estimation with Selective Aggregated Transformercited by 7
  23. 2025How Effective Can Dropout Be in Multiple Instance Learning ?cited by 7
  24. 2021Non-I.I.D. Multi-Instance Learning for Predicting Instance and Bag Labels using Variational Auto-Encodercited by 6
  25. 2021Multi-Attention Multiple Instance Learningcited by 6
  26. 2022Bag Graph: Multiple Instance Learning using Bayesian Graph Neural Networkscited by 6
  27. 2022All Grains, One Scheme (AGOS): Learning Multi-grain Instance Representation for Aerial Scene Classificationcited by 6
  28. 2023Multi-level Multiple Instance Learning with Transformer for Whole Slide Image Classificationcited by 6
  29. 2023PDL: Regularizing Multiple Instance Learning with Progressive Dropout Layerscited by 6
  30. 2023Data efficient deep learning for medical image analysis: A surveycited by 6
  31. 2023SC-MIL: Sparsely Coded Multiple Instance Learning for Whole Slide Image Classificationcited by 6
  32. 2024Integrative Graph-Transformer Framework for Histopathology Whole Slide Image Representation and Classificationcited by 6
  33. 2024Learning from Partial Label Proportions for Whole Slide Image Segmentationcited by 6
  34. 2024SAM-MIL: A Spatial Contextual Aware Multiple Instance Learning Approach for Whole Slide Image Classificationcited by 6
  35. 2025Self-Supervision Enhances Instance-based Multiple Instance Learning Methods in Digital Pathology: A Benchmark Studycited by 6
  36. 2021Learning with Group Noisecited by 5
  37. 2022Psychophysiological Arousal in Young Children Who Stutter: An Interpretable AI Approachcited by 5
  38. 2023Attention2Minority: A salient instance inference-based multiple instance learning for classifying small lesions in whole slide imagescited by 5

50 most cited of 119 All 119 (JSON)