Revisiting Multiple Instance Neural Networks
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Abstract (arXiv)
Recently neural networks and multiple instance learning are both attractive topics in Artificial Intelligence related research fields. Deep neural networks have achieved great success in supervised learning problems, and multiple instance learning as a typical weakly-supervised learning method is effective for many applications in computer vision, biometrics, nature language processing, etc. In this paper, we revisit the problem of solving multiple instance learning problems using neural networks. Neural networks are appealing for solving multiple instance learning problem. The multiple instance neural networks perform multiple instance learning in an end-to-end way, which take a bag with various number of instances as input and directly output bag label. All of the parameters in a multiple instance network are able to be optimized via back-propagation. We propose a new multiple instance neural network to learn bag representations, which is different from the existing multiple instance neural networks that focus on estimating instance label. In addition, recent tricks developed in deep learning have been studied in multiple instance networks, we find deep supervision is effective for boosting bag classification accuracy. In the experiments, the proposed multiple instance networks achieve state-of-the-art or competitive performance on several MIL benchmarks. Moreover, it is extremely fast for both testing and training, e.g., it takes only 0.0003 second to predict a bag and a few seconds to train on a MIL datasets on a moderate CPU.
Key facts. Cited by 119 papers in the map (data through 7 Oct 2026). First posted on arXiv 8 Oct 2016.
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Citing papers per year: 2021: 15; 2022: 26; 2023: 36; 2024: 19; 2025: 15; 2026: 8.
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- 2021TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classificationcited by 549
- 2022DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classificationcited by 254
- 2022Catching Both Gray and Black Swans: Open-set Supervised Anomaly Detectioncited by 104
- 2023Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Imagescited by 91
- 2023Dual Memory Units with Uncertainty Regulation for Weakly Supervised Video Anomaly Detectioncited by 88
- 2021Weakly Supervised Object Localization and Detection: A Surveycited by 84
- 2021Explainable Deep Few-shot Anomaly Detection with Deviation Networkscited by 69
- 2023Multiple Instance Learning Framework with Masked Hard Instance Mining for Whole Slide Image Classificationcited by 58
- 2022Bi-directional Weakly Supervised Knowledge Distillation for Whole Slide Image Classificationcited by 42
- 2022Towards Label-efficient Automatic Diagnosis and Analysis: A Comprehensive Survey of Advanced Deep Learning-based Weakly-supervised, Semi-supervised and Self-supervised Techniques in Histopathological Image Analysiscited by 29
- 2023Diagnose Like a Pathologist: Transformer-Enabled Hierarchical Attention-Guided Multiple Instance Learning for Whole Slide Image Classificationcited by 27
- 2024Generalizable Whole Slide Image Classification with Fine-Grained Visual-Semantic Interactioncited by 27
38 more
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- 2023Inherently Interpretable Time Series Classification via Multiple Instance Learningcited by 23
- 2021ProtoMIL: Multiple Instance Learning with Prototypical Parts for Whole-Slide Image Classificationcited by 22
- 2023Rethinking Multiple Instance Learning for Whole Slide Image Classification: A Good Instance Classifier is All You Needcited by 21
- 2022Multi-Instance Causal Representation Learning for Instance Label Prediction and Out-of-Distribution Generalizationcited by 17
- 2021Label Cleaning Multiple Instance Learning: Refining Coarse Annotations on Single Whole-Slide Imagescited by 13
- 2022Interventional Multi-Instance Learning with Deconfounded Instance-Level Predictioncited by 13
- 2022Non-Markovian Reward Modelling from Trajectory Labels via Interpretable Multiple Instance Learningcited by 13
- 2023CAMIL: Context-Aware Multiple Instance Learning for Cancer Detection and Subtyping in Whole Slide Imagescited by 13
- 2024TimeMIL: Advancing Multivariate Time Series Classification via a Time-aware Multiple Instance Learningcited by 12
- 2023Reproducibility in Multiple Instance Learning: A Case For Algorithmic Unit Testscited by 11
- 2024Agent Aggregator with Mask Denoise Mechanism for Histopathology Whole Slide Image Analysiscited by 11
- 2022Model Agnostic Interpretability for Multiple Instance Learningcited by 10
- 2022DSCA: A Dual-Stream Network with Cross-Attention on Whole-Slide Image Pyramids for Cancer Prognosiscited by 10
- 2023Disambiguated Attention Embedding for Multi-Instance Partial-Label Learningcited by 9
- 2023A Unified Approach to Count-Based Weakly-Supervised Learningcited by 9
- 2023Probabilistic Attention based on Gaussian Processes for Deep Multiple Instance Learningcited by 8
- 2022EGFR Mutation Prediction of Lung Biopsy Images using Deep Learningcited by 7
- 2023Detecting Heart Disease from Multi-View Ultrasound Images via Supervised Attention Multiple Instance Learningcited by 7
- 2024From Correlation to Causation: Max-Pooling-Based Multi-Instance Learning Leads to More Robust Whole Slide Image Classificationcited by 7
- 2024MergeUp-augmented Semi-Weakly Supervised Learning for WSI Classificationcited by 7
- 2024Ordinal Multiple-instance Learning for Ulcerative Colitis Severity Estimation with Selective Aggregated Transformercited by 7
- 2025How Effective Can Dropout Be in Multiple Instance Learning ?cited by 7
- 2021Non-I.I.D. Multi-Instance Learning for Predicting Instance and Bag Labels using Variational Auto-Encodercited by 6
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- 2023Multi-level Multiple Instance Learning with Transformer for Whole Slide Image Classificationcited by 6
- 2023PDL: Regularizing Multiple Instance Learning with Progressive Dropout Layerscited by 6
- 2023Data efficient deep learning for medical image analysis: A surveycited by 6
- 2023SC-MIL: Sparsely Coded Multiple Instance Learning for Whole Slide Image Classificationcited by 6
- 2024Integrative Graph-Transformer Framework for Histopathology Whole Slide Image Representation and Classificationcited by 6
- 2024Learning from Partial Label Proportions for Whole Slide Image Segmentationcited by 6
- 2024SAM-MIL: A Spatial Contextual Aware Multiple Instance Learning Approach for Whole Slide Image Classificationcited by 6
- 2025Self-Supervision Enhances Instance-based Multiple Instance Learning Methods in Digital Pathology: A Benchmark Studycited by 6
- 2021Learning with Group Noisecited by 5
- 2022Psychophysiological Arousal in Young Children Who Stutter: An Interpretable AI Approachcited by 5
- 2023Attention2Minority: A salient instance inference-based multiple instance learning for classifying small lesions in whole slide imagescited by 5
50 most cited of 119 All 119 (JSON)
- 2026MoSPR: Histology-to-Gene Expression Prediction with Morpho-Spatial Macrostates and Low-Rank Molecular Programs28 Sep 2026
- 2026Towards Whole-Study Screening for Congenital Heart Disease in Fetal Ultrasound Using Multiple Instance Learning25 Sep 2026
- 2026Statistical Testing for Multiple Instance Learning via Selective Inference with Applications to Computational Pathology21 Sep 2026
- 2026Weakly-supervised Kidney Tumor Classification from CT Scans with Multi-Instance Learning and Anatomical Filtering7 Sep 2026
- 2026Rethinking EEG-Based Disease Diagnosis: Decoupling Instance Representation Learning from Subject-Level Supervision29 Jul 2026
- 2026Weakly Supervised Instance-Level Gleason Pattern Estimation Using Primary and Secondary Labels26 Jul 2026
- 2026Cell-Type Prototype-Informed Neural Network for Gene Expression Estimation from Pathology Images19 Mar 2026
- 2026Hypernetwork-Based Adaptive Aggregation for Multimodal Multiple-Instance Learning in Predicting Coronary Calcium Debulking29 Jan 2026
- 2025Calibratable Disambiguation Loss for Multi-Instance Partial-Label Learning19 Dec 2025
- 2025A deep multiple instance learning approach based on coarse labels for high-resolution land-cover mapping8 Oct 2025
- 2025Concepts in Motion: Temporal Concept Bottleneck Model for Interpretable Video Classification25 Sep 2025
- 2025Multiple Instance Learning Framework with Masked Hard Instance Mining for Gigapixel Histopathology Image Analysis15 Sep 2025
38 more
- 2025Learning from Majority Label: A Novel Problem in Multi-class Multiple-Instance Learning4 Sep 2025
- 2025Cracking Instance Jigsaw Puzzles: An Alternative to Multiple Instance Learning for Whole Slide Image Analysis10 Jul 2025
- 2025Classification of autoimmune diseases from Peripheral blood TCR repertoires by multimodal multi-instance learning7 Jul 2025
- 2025FMaMIL: Frequency-Driven Mamba Multi-Instance Learning for Weakly Supervised Lesion Segmentation in Medical Images9 Jun 2025
- 2025Dual-stream attention-guided learning for weakly supervised whole slide image classification29 May 2025
- 2025Denoising Mutual Knowledge Distillation in Bi-Directional Multiple Instance Learning17 May 2025
- 2025SimMIL: A Universal Weakly Supervised Pre-Training Framework for Multi-Instance Learning in Whole Slide Pathology Images10 May 2025
- 2025Self-Supervision Enhances Instance-based Multiple Instance Learning Methods in Digital Pathology: A Benchmark Study2 May 2025
- 2025How Effective Can Dropout Be in Multiple Instance Learning ?21 Apr 2025
- 2025Beyond Deepfake vs Real: Facial Deepfake Detection in the Open-Set Paradigm11 Mar 2025
- 2025Multi-Instance Partial-Label Learning with Margin Adjustment22 Jan 2025
- 2024Ordinal Multiple-instance Learning for Ulcerative Colitis Severity Estimation with Selective Aggregated Transformer22 Nov 2024
- 2024Advancing Histopathology with Deep Learning Under Data Scarcity: A Decade in Review18 Oct 2024
- 2024Agent Aggregator with Mask Denoise Mechanism for Histopathology Whole Slide Image Analysis18 Sep 2024
- 2024Exploiting Conjugate Label Information for Multi-Instance Partial-Label Learning26 Aug 2024
- 2024MergeUp-augmented Semi-Weakly Supervised Learning for WSI Classification23 Aug 2024
- 2024From Correlation to Causation: Max-Pooling-Based Multi-Instance Learning Leads to More Robust Whole Slide Image Classification18 Aug 2024
- 2024SAM-MIL: A Spatial Contextual Aware Multiple Instance Learning Approach for Whole Slide Image Classification25 Jul 2024
- 2024FALFormer: Feature-aware Landmarks self-attention for Whole-slide Image Classification10 Jul 2024
- 2024Multiple Instance Verification9 Jul 2024
- 2024DGR-MIL: Exploring Diverse Global Representation in Multiple Instance Learning for Whole Slide Image Classification4 Jul 2024
- 2024Enhancing Multimodal Large Language Models with Multi-instance Visual Prompt Generator for Visual Representation Enrichment5 Jun 2024
- 2024Comparing ImageNet Pre-training with Digital Pathology Foundation Models for Whole Slide Image-Based Survival Analysis20 May 2024
- 2024Learning from Partial Label Proportions for Whole Slide Image Segmentation15 May 2024
- 2024TimeMIL: Advancing Multivariate Time Series Classification via a Time-aware Multiple Instance Learning6 May 2024
- 2024Modeling Multi-Granularity Context Information Flow for Pavement Crack Detection19 Apr 2024
- 2024Integrative Graph-Transformer Framework for Histopathology Whole Slide Image Representation and Classification26 Mar 2024
- 2024Counting Network for Learning from Majority Label20 Mar 2024
- 2024Generalizable Whole Slide Image Classification with Fine-Grained Visual-Semantic Interaction29 Feb 2024
- 2024Cross-Level Multi-Instance Distillation for Self-Supervised Fine-Grained Visual Categorization16 Jan 2024
- 2023MIVC: Multiple Instance Visual Component for Visual-Language Models28 Dec 2023
- 2023A Unified Approach to Count-Based Weakly-Supervised Learning22 Nov 2023
- 2023Inherently Interpretable Time Series Classification via Multiple Instance Learning16 Nov 2023
- 2023SC-MIL: Sparsely Coded Multiple Instance Learning for Whole Slide Image Classification31 Oct 2023
- 2023Reproducibility in Multiple Instance Learning: A Case For Algorithmic Unit Tests27 Oct 2023
- 2023Case-level Breast Cancer Prediction for Real Hospital Settings19 Oct 2023
- 2023Data efficient deep learning for medical image analysis: A survey10 Oct 2023
- 2023Cross-attention-based saliency inference for predicting cancer metastasis on whole slide images18 Sep 2023
50 newest of 119 All 119 (JSON)
- 2021TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classificationcited by 549
- 2022DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classificationcited by 254
- 2022Catching Both Gray and Black Swans: Open-set Supervised Anomaly Detectioncited by 104
- 2023Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Imagescited by 91
- 2023Dual Memory Units with Uncertainty Regulation for Weakly Supervised Video Anomaly Detectioncited by 88
- 2021Weakly Supervised Object Localization and Detection: A Surveycited by 84
- 2021Explainable Deep Few-shot Anomaly Detection with Deviation Networkscited by 69
- 2023Multiple Instance Learning Framework with Masked Hard Instance Mining for Whole Slide Image Classificationcited by 58
- 2022Bi-directional Weakly Supervised Knowledge Distillation for Whole Slide Image Classificationcited by 42
- 2022Towards Label-efficient Automatic Diagnosis and Analysis: A Comprehensive Survey of Advanced Deep Learning-based Weakly-supervised, Semi-supervised and Self-supervised Techniques in Histopathological Image Analysiscited by 29
- 2023Diagnose Like a Pathologist: Transformer-Enabled Hierarchical Attention-Guided Multiple Instance Learning for Whole Slide Image Classificationcited by 27
- 2024Generalizable Whole Slide Image Classification with Fine-Grained Visual-Semantic Interactioncited by 27
12 most cited of 115 All 115 (JSON)
- 2026MoSPR: Histology-to-Gene Expression Prediction with Morpho-Spatial Macrostates and Low-Rank Molecular Programs28 Sep 2026
- 2026Towards Whole-Study Screening for Congenital Heart Disease in Fetal Ultrasound Using Multiple Instance Learning25 Sep 2026
- 2026Statistical Testing for Multiple Instance Learning via Selective Inference with Applications to Computational Pathology21 Sep 2026
- 2026Weakly-supervised Kidney Tumor Classification from CT Scans with Multi-Instance Learning and Anatomical Filtering7 Sep 2026
- 2026Rethinking EEG-Based Disease Diagnosis: Decoupling Instance Representation Learning from Subject-Level Supervision29 Jul 2026
- 2026Weakly Supervised Instance-Level Gleason Pattern Estimation Using Primary and Secondary Labels26 Jul 2026
- 2026Cell-Type Prototype-Informed Neural Network for Gene Expression Estimation from Pathology Images19 Mar 2026
- 2026Hypernetwork-Based Adaptive Aggregation for Multimodal Multiple-Instance Learning in Predicting Coronary Calcium Debulking29 Jan 2026
- 2025Calibratable Disambiguation Loss for Multi-Instance Partial-Label Learning19 Dec 2025
- 2025A deep multiple instance learning approach based on coarse labels for high-resolution land-cover mapping8 Oct 2025
- 2025Concepts in Motion: Temporal Concept Bottleneck Model for Interpretable Video Classification25 Sep 2025
- 2025Multiple Instance Learning Framework with Masked Hard Instance Mining for Gigapixel Histopathology Image Analysis15 Sep 2025
12 newest of 115 All 115 (JSON)