MedHarnessBench: A Unified Benchmark for Healthcare Agent Evaluation
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Abstract (arXiv)
Healthcare agents must transform longitudinal clinical evidence into reliable actions through heterogeneous tools and stateful workflows, conditions under which model-centric systems may lose context, misuse tools, fail to verify consequential transitions, or cross authorization boundaries. Existing medical-agent benchmarks primarily emphasize terminal task outcomes, making it difficult to determine whether execution failures arise from the agent model, the runtime harness, or their interaction. We present the Medical Harness Protocol, an outcome-preserving framework that independently evaluates seven healthcare-specific process dimensions: Care Action Fulfillment, Clinical Resource Competence, Patient-Evidence Alignment, Clinical Workflow Continuity, Clinical Auditability, Closed-Loop Verification, and Clinical Conduct Boundaries. A normalized intervention trace further tracks whether runtime support is available, activated, delivered, adopted by the agent, and propagated into subsequent behavior. We instantiate the protocol as MedHarnessBench, comprising 342 executable tasks across FHIR/EHR operations, healthcare-administration interfaces, and multimodal clinical tools. Across more than 16,000 controlled task executions, MedHarness yields broad improvements in terminal task success, intermediate subtask completion, and healthcare-specific process quality. We further evaluate MedHarness against multiple general-purpose harnesses and use controlled single-fault perturbations to verify the sensitivity and discrimination of the seven-dimensional evaluation. These results demonstrate that healthcare-specific runtime support can substantially improve both task completion and execution quality, while revealing failures that terminal outcomes alone cannot capture. Code and resources are available at https://github.com/Tomry1114/Awesome-Agent-Harness-for-Healthcare.
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References · 16
- 2022ReAct: Synergizing Reasoning and Acting in Language Modelscited by 8,695
- 2023Reflexion: Language Agents with Verbal Reinforcement Learningcited by 4,276
- 2023Voyager: An Open-Ended Embodied Agent with Large Language Modelscited by 2,191
- 2024SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineeringcited by 1,737
- 2023ExpeL: LLM Agents Are Experiential Learnerscited by 876
- 2025HealthBench: Evaluating Large Language Models Towards Improved Human Healthcited by 429
- 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 231
- 2025MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agentscited by 62
- 2026Natural-Language Agent Harnessescited by 61
- 2026Harness-Bench: Measuring Harness Effects across Models in Realistic Agent Workflowscited by 57
- 2026PhysicianBench: Evaluating LLM Agents in Real-World EHR Environmentscited by 21
- 2026HealthAdminBench: Evaluating Computer-Use Agents on Healthcare Administration Taskscited by 13
4 more
- 2026Auditing Agent Harness Safetycited by 11
- 2026CHI-Bench: Can AI Agents Automate End-to-End, Long-Horizon, Policy-Rich Healthcare Workflows?cited by 8
- 2026HealthAgentBench: A Unified Benchmark Suite of Realistic Agentic Healthcare Environments for Challenging Frontier AI Agentscited by 8
- 2026MedCTA: A Benchmark for Clinical Tool Agentscited by 3
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- 2026MedicalHarness: A Controlled Evaluation of LLMs and Agent Harnesses on Medical Tasks
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- 2025Auditing medical multi-agent AI reveals risks of false consensus
- 2026MedConsultBench: A Full-Cycle, Fine-Grained, Process-Aware Benchmark for Medical Consultation Agents
- 2026Asclepius: An Adaptive Harness for Long-Horizon Clinical Agents
- 2026MedCUA-Bench: A Screenshot-Only Benchmark for Clinical Computer-Use Agents
- 2026Measuring What Matters: Benchmarking Generative, Multimodal, and Agentic AI in Healthcare