MedLLM: An Open Medical Language Model at the Sub-Billion Scale
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Abstract (arXiv)
Open medical language models have converged on a single scale: every widely used system runs at 7B parameters or more, leaving the sub-billion regime uncharacterized. We present MedLLM, an open 0.1B-parameter medical language model trained through a fully open three-phase pipeline: general pretraining with curriculum sequence-length scheduling, domain fine-tuning on MedFineWeb, a reference-guided medical corpus we release that is selected from general web data by embedding similarity to medical question-answering (QA) data, and preference-aligned fine-tuning combining SFT with direct preference optimization (DPO). Across medical benchmarks, MedLLM shows a pattern visible only at sub-billion scale: medical competence does not degrade uniformly under compression but splits by task type. On context-grounded QA it comes within 2.9pp of a medically adapted 7B model and surpasses the instruction-tuned and general-purpose 7B baselines; on knowledge-recall QA it stays near the task floor on clinical-vignette MedQA yet significantly exceeds every 7B and sub-7B baseline on MedMCQA, indicating that where recall fails the constraint is model capacity rather than adaptation. This dissociation is masked at 7B, where both capabilities are present, and surfaces only when capacity is scarce.
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References · 24
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- 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
- 2020Domain-Specific Language Model Pretraining for Biomedical Natural Language Processingcited by 996
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- 2023MEDITRON-70B: Scaling Medical Pretraining for Large Language Models
- 2024The Limited Impact of Medical Adaptation of Large Language and Vision-Language Models
- 2024A Survey for Large Language Models in Biomedicine
- 2024OpenMedLM: Prompt engineering can out-perform fine-tuning in medical question-answering with open-source large language models
- 2025Generalization of Medical Large Language Models through Cross-Domain Weak Supervision
- 2025IIMedGPT: Promoting Large Language Model Capabilities of Medical Tasks by Efficient Human Preference Alignment
- 2024MedCare: Advancing Medical LLMs through Decoupling Clinical Alignment and Knowledge Aggregation
- 2024LLM-MedQA: Enhancing Medical Question Answering through Case Studies in Large Language Models