mlsanityData to 7 Oct 2026

ClinEnv: An Interactive Multi-Stage Long Horizon EHR Environment for Agents

arXiv 2606.02568 ↗First posted 1 Jun 2026cs.AI cs.CL cs.ETcited by 4

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

Clinical practice is not the selection of an answer from enumerated options: a physician gathers heterogeneous information incrementally and commits to sequential, irreversible decisions under uncertainty. Static benchmarks cannot probe and existing interactive medical benchmarks each compromise on at least one of them. We present ClinEnv, an interactive benchmark that evaluates LLMs as attending physicians over real inpatient admissions under a paradigm we term Longitudinal Inpatient Simulation. Each case is automatically constructed into an ordered sequence of decision stages; at every stage the model must actively query four specialized agents before committing to medications, procedures, and diagnoses. ClinEnv scores both what the model decides, through deterministic ontology-grounded matching, and how it gathers information. Across seven models, the strongest reaches only 0.31 decision F1, and outcome quality is sharply decoupled from process quality. Difficulty concentrates in management decisions and later stages, where models recover discharge diagnoses far more reliably than management actions (0.51 vs. 0.17 F1) and continue to issue redundant queries as cases progress. ClinEnv makes this information-acquisition gap, invisible to outcome-only evaluation, directly measurable.

Key facts. Cited by 4 papers in the map (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 9 of its 21 references that are in the map. First posted on arXiv 1 Jun 2026.

Builds on

9 of 21 references.

Closest ancestors · 1

Same direction, newest first

  1. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments13 May

Other references · 8

  1. 2020Measuring Massive Multitask Language Understandingcited by 7,768
  2. 2023SWE-bench: Can Language Models Resolve Real-World GitHub Issues?cited by 3,193
  3. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  4. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  5. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  6. 2023Capabilities of GPT-4 on Medical Challenge Problemscited by 630
  7. 2019Text-to-SQL Generation for Question Answering on Electronic Medical Recordscited by 76
  8. 2026MedDialBench: Benchmarking LLM Diagnostic Robustness under Parametric Adversarial Patient Behaviorscited by 4

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2026: 4.

4 papers.

Similar, not cited

Close in wording, no citation either way

  1. 2026LongMedBench: Benchmarking Medical Agents for Long-Horizon Clinical Decision-Making
  2. 2026EHR-Complex: Benchmarking Medical Agents for Complex Clinical Reasoning
  3. 2026ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoning
  4. 2026PhysicianBench: Evaluating LLM Agents in Real-World EHR Environments
  5. 2025MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents
  6. 2025DynamiCare: A Dynamic Multi-Agent Framework for Interactive and Open-Ended Medical Decision-Making
  7. 2026EHRWorld: A Patient-Centric Medical World Model for Long-Horizon Clinical Trajectories
  8. 2026EHR-RobustGym: Benchmarking and Training Agents for Robust Clinical Reasoning