Rethinking Visual Attribution for Chest X-ray Reasoning in Large Vision Language Models
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Large Vision Language Models (LVLMs) show promise in medical applications, but their inability to faithfully ground responses in visual evidence raises serious concerns about clinical trustworthiness. While visual attribution methods are widely used to explain LVLM predictions, whether these explanations actually reflect the visual evidence underlying the model's decision is largely unverified, since ground-truth annotations for internal model reasoning are typically unavailable. We address this question for chest X-ray (CXR) reasoning by developing a causal evaluation framework that retains only CXR-VQA samples for which the expert-annotated region is verified, via counterfactual editing, to be causally responsible for the model's prediction. Using this framework across 11 attribution methods, six open-source LVLMs, and two output modes (direct answer and step-by-step reasoning), we find that existing attribution methods often fail to identify the evidence used by LVLMs. To address this failure, we propose MedFocus, a concept-based attribution method that localizes clinically meaningful anatomical regions via unbalanced optimal transport and measures their causal effect on model outputs through targeted interventions. MedFocus produces spatial, concept-level, and token-level attributions and substantially outperforms prior methods, taking a step toward more trustworthy attribution for medical LVLMs. Our data and code are available at https://github.com/gzxiong/medfocus/.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 16 of its 79 references that are in the map. First posted on arXiv 19 May 2026.
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References · 16
- 2025Qwen2.5-VL Technical Reportcited by 5,587
- 2013Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Mapscited by 2,371
- 2023Qwen-VL: A Versatile Vision-Language Model for Understanding, Localization, Text Reading, and Beyondcited by 2,224
- 2025Gemma 3 Technical Reportcited by 1,824
- 2025SAM 3: Segment Anything with Conceptscited by 906
- 2023Capabilities of GPT-4 on Medical Challenge Problemscited by 638
- 2019MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographscited by 597
- 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 475
- 2025MedGemma Technical Reportcited by 436
- 2025OmniGen2: Towards Instruction-Aligned Multimodal Generationcited by 253
- 2025MedSAM2: Segment Anything in 3D Medical Images and Videoscited by 96
- 2025Grounded Chain-of-Thought for Multimodal Large Language Modelscited by 59
4 more
- 2025MedSAM3: Delving into Segment Anything with Medical Conceptscited by 26
- 2024Generative Enhancement for 3D Medical Imagescited by 14
- 2026CT-Bench: A Benchmark for Multimodal Lesion Understanding in Computed Tomographycited by 3
- 2026Med-V1: Small Language Models for Zero-shot and Scalable Biomedical Evidence Attributioncited by 2
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- 2026MC-CXR: A Multi-Context Chest X-ray Benchmark for Context-Induced Disruption in Vision-Language Models
- 2026CheXthought: A global multimodal dataset of clinical chain-of-thought reasoning and visual attention for chest X-ray interpretation
- 2025Reasoning Visual Language Model for Chest X-Ray Analysis
- 2025Evaluating Reasoning Faithfulness in Medical Vision-Language Models using Multimodal Perturbations
- 2025XBench: A Comprehensive Benchmark for Visual-Language Explanations in Chest Radiography
- 2025CXReasonBench: A Benchmark for Evaluating Structured Diagnostic Reasoning in Chest X-rays
- 2026Medical Context Distorts Decisions in Clinical Vision Language Models
- 2026Vision-language models for chest radiography do not always need the image