mlsanityData to 7 Oct 2026

Modeling Clinical Concern Trajectories in Language Model Agents

arXiv 2604.27872 ↗First posted 30 Apr 2026cs.AIcited by 0

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

Large language model (LLM) agents deployed in clinical settings often exhibit abrupt, threshold-driven behavior, offering little visibility into accumulating risk prior to escalation. In real-world care, however, clinicians act on gradually rising concern rather than instantaneous triggers. We study whether explicit state dynamics can expose such pre-escalation signals without delegating clinical authority to the agent. We introduce a lightweight agent architecture in which a memoryless clinical risk encoder is integrated over time using first- and second-order dynamics to produce a continuous escalation pressure signal. Across synthetic ward scenarios, stateless agents exhibit sharp escalation cliffs, while second-order dynamics produce smooth, anticipatory concern trajectories despite similar escalation timing. These trajectories surface sustained unease prior to escalation, enabling human-in-the-loop monitoring and more informed intervention. Our results suggest that explicit state dynamics can make LLM agents more clinically legible by revealing how long concern has been rising, not just when thresholds are crossed.

Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 9 of its 21 references that are in the map. First posted on arXiv 30 Apr 2026.

Builds on

9 of 21 references.

Closest ancestors · 2

Same direction, newest first

  1. 2024Adaptive Reasoning and Acting in Medical Language Agents13 Oct
  2. 2024ArgMed-Agents: Explainable Clinical Decision Reasoning with LLM Disscusion via Argumentation Schemes10 Mar

Other references · 7

  1. 2024Qwen2.5 Technical Reportcited by 4,713
  2. 2021Unifying Cardiovascular Modelling with Deep Reinforcement Learning for Uncertainty Aware Control of Sepsis Treatmentcited by 16
  3. 2024A Demonstration of Adaptive Collaboration of Large Language Models for Medical Decision-Makingcited by 5
  4. 2026Controlling Long-Horizon Behavior in Language Model Agents with Explicit State Dynamicscited by 3
  5. 2021Personalized and Reliable Decision Sets: Enhancing Interpretability in Clinical Decision Support Systemscited by 1
  6. 2023Evaluating the impact of an explainable machine learning system on the interobserver agreement in chest radiograph interpretationcited by 1
  7. 2023A New Deep State-Space Analysis Framework for Patient Latent State Estimation and Classification from EHR Time Series Datacited by 1

Built on by

Not cited yet.

Similar, not cited

Close in wording, no citation either way

  1. 2026GPAgentBench-2K: Benchmarking Large Language Model Agents in Complex Clinical Action Space
  2. 2026Future Querying: Can LLMs Serve as Implicit Medical World Models?
  3. 2026Evaluating Large Language Models in Dynamic Clinical Decision-Making with Standardized Patient Cases
  4. 2025CP-Env: Evaluating Large Language Models on Clinical Pathways in a Controllable Hospital Environment
  5. 2026ChronoMedicalWorld: A Medical World Model for Learning Patient Trajectories from Longitudinal Care Data
  6. 2025BehaviorSFT: Behavioral Token Conditioning for Clinical Agents Across the Proactivity Spectrum
  7. 2026CareGuardAI: Context-Aware Multi-Agent Guardrails for Clinical Safety & Hallucination Mitigation in Patient-Facing LLMs
  8. 2026Agentifying Patient Dynamics within LLMs through Interacting with Clinical World Model