mlsanityData to 7 Oct 2026

Why Does Grounding Hurt Medical VQA? Benchmarking, Diagnosis, and Fine-Tuning of Vision-Language Models

arXiv 2604.27720 ↗First posted 30 Apr 2026cs.AIcited by 1

On the map: Multimodal LLMs / vision-language models → Medical vision-language models

Abstract (arXiv)

Vision-language models (VLMs) are increasingly applied to medical visual question answering (Med-VQA), yet whether they can localize the evidence behind their answers---a prerequisite for clinical auditability---is poorly characterized. We separately evaluate VQA reasoning and visual grounding for four recent frontier VLMs (GPT-5.1, GPT-5.5, Gemini-2.5-Pro, Gemini-3-Flash), two domain-specific medical VLMs (Lingshu, MedGemma), and a dedicated open-vocabulary detector (Grounding DINO) on VQA-RAD and SLAKE. Two findings challenge the intuition that ``add grounding to improve VQA.'' First, no model localizes medical targets well: every off-the-shelf system---frontier, medical-specialized, or dedicated detector---scores mean IoU 0.05--0.24 on our SLAKE grounding split, at or barely above a trivial center-box baseline (0.10), with [email protected] below 20%. Second, and counter to the common ``localize-then-answer'' paradigm, cropping to a bounding box degrades VQA even when the box is a perfect oracle: on the matched subset where oracle ground-truth boxes are applied, GT-grounding lowers closed-ended accuracy for every model (by 0.9--18.0 points versus using the full image)---consistent with the crop discarding global context the model relies on. Because the oracle box removes localization error by construction, the problem is not that perception is a recoverable bottleneck, but that grounding-by-cropping is itself the wrong interface. Finally, we show constructively that the two channels need not conflict: supervised fine-tuning of Qwen-2.5-VL-7B on answers alone silently destroys box-evidence emission (0/418 parseable boxes), whereas mixing in a small amount of grounding supervision restores localization to 0.36 IoU---above every zero-shot model---while preserving answer accuracy.

Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 18 of its 21 references that are in the map. First posted on arXiv 30 Apr 2026.

Builds on

18 of 21 references.

Closest ancestors · 2

Same direction, newest first

  1. 2025How Far Have Medical Vision-Language Models Come? A Comprehensive Benchmarking Study15 Jul
  2. 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day1 Jun

Other references · 16

  1. 2021Learning Transferable Visual Models From Natural Language Supervisioncited by 33,456
  2. 2023Segment Anythingcited by 8,158
  3. 2023Visual Instruction Tuningcited by 7,792
  4. 2025Qwen2.5-VL Technical Reportcited by 5,418
  5. 2024GPT-4o System Cardcited by 4,467
  6. 2022BLIP: Bootstrapping Language-Image Pre-training for Unified Vision-Language Understanding and Generationcited by 4,310
  7. 2025Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilitiescited by 3,655
  8. 2023Grounding DINO: Marrying DINO with Grounded Pre-Training for Open-Set Object Detectioncited by 3,274
  9. 2023InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Taskscited by 2,534
  10. 2023BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairscited by 506
  11. 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
  12. 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
4 more
  1. 2025GLM-4.5V and GLM-4.1V-Thinking: Towards Versatile Multimodal Reasoning with Scalable Reinforcement Learningcited by 439
  2. 2023Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Modelscited by 58
  3. 2023Q2ATransformer: Improving Medical VQA via an Answer Querying Decodercited by 31
  4. 2025TTRV: Test-Time Reinforcement Learning for Vision Language Modelscited by 8

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Citing papers per year: 2026: 1.

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  1. 2026To Agree or To Be Right? The Grounding-Sycophancy Tradeoff in Medical Vision-Language Models
  2. 2026From Reasoning to Pixels: Grounded Medical Multimodal LLMs for VQA and Segmentation
  3. 2025Are Large Vision Language Models Truly Grounded in Medical Images? Evidence from Italian Clinical Visual Question Answering
  4. 2026Do Medical Vision Language Models Actually See? A Counterfactual Grounding Framework and Hard-Negative Contrastive Training for Visually-Reliant Medical VLMs
  5. 2026How Do Medical MLLMs Fail? A Study on Visual Grounding in Medical Images
  6. 2024SURE-VQA: Systematic Understanding of Robustness Evaluation in Medical VQA Tasks
  7. 2025Benchmarking and Mitigating Sycophancy in Medical Vision Language Models
  8. 2025CoTBox-TTT: Grounding Medical VQA with Visual Chain-of-Thought Boxes During Test-time Training