Why Does Grounding Hurt Medical VQA? Benchmarking, Diagnosis, and Fine-Tuning of Vision-Language Models
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
Vision-language models (VLMs) are increasingly applied to medical visual question answering (Med-VQA), yet whether they can localize the evidence behind their answers---a prerequisite for clinical auditability---is poorly characterized. We separately evaluate VQA reasoning and visual grounding for four recent frontier VLMs (GPT-5.1, GPT-5.5, Gemini-2.5-Pro, Gemini-3-Flash), two domain-specific medical VLMs (Lingshu, MedGemma), and a dedicated open-vocabulary detector (Grounding DINO) on VQA-RAD and SLAKE. Two findings challenge the intuition that ``add grounding to improve VQA.'' First, no model localizes medical targets well: every off-the-shelf system---frontier, medical-specialized, or dedicated detector---scores mean IoU 0.05--0.24 on our SLAKE grounding split, at or barely above a trivial center-box baseline (0.10), with [email protected] below 20%. Second, and counter to the common ``localize-then-answer'' paradigm, cropping to a bounding box degrades VQA even when the box is a perfect oracle: on the matched subset where oracle ground-truth boxes are applied, GT-grounding lowers closed-ended accuracy for every model (by 0.9--18.0 points versus using the full image)---consistent with the crop discarding global context the model relies on. Because the oracle box removes localization error by construction, the problem is not that perception is a recoverable bottleneck, but that grounding-by-cropping is itself the wrong interface. Finally, we show constructively that the two channels need not conflict: supervised fine-tuning of Qwen-2.5-VL-7B on answers alone silently destroys box-evidence emission (0/418 parseable boxes), whereas mixing in a small amount of grounding supervision restores localization to 0.36 IoU---above every zero-shot model---while preserving answer accuracy.
Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 18 of its 21 references that are in the map. First posted on arXiv 30 Apr 2026.
Builds on
18 of 21 references.
Closest ancestors · 2
Same direction, newest first
- 2025How Far Have Medical Vision-Language Models Come? A Comprehensive Benchmarking Study15 Jul
- 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day1 Jun
Other references · 16
- 2021Learning Transferable Visual Models From Natural Language Supervisioncited by 33,456
- 2023Segment Anythingcited by 8,158
- 2023Visual Instruction Tuningcited by 7,792
- 2025Qwen2.5-VL Technical Reportcited by 5,418
- 2024GPT-4o System Cardcited by 4,467
- 2022BLIP: Bootstrapping Language-Image Pre-training for Unified Vision-Language Understanding and Generationcited by 4,310
- 2025Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilitiescited by 3,655
- 2023Grounding DINO: Marrying DINO with Grounded Pre-Training for Open-Set Object Detectioncited by 3,274
- 2023InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Taskscited by 2,534
- 2023BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairscited by 506
- 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
- 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
4 more
- 2025GLM-4.5V and GLM-4.1V-Thinking: Towards Versatile Multimodal Reasoning with Scalable Reinforcement Learningcited by 439
- 2023Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Modelscited by 58
- 2023Q2ATransformer: Improving Medical VQA via an Answer Querying Decodercited by 31
- 2025TTRV: Test-Time Reinforcement Learning for Vision Language Modelscited by 8
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Citing papers per year: 2026: 1.
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- 2025Are Large Vision Language Models Truly Grounded in Medical Images? Evidence from Italian Clinical Visual Question Answering
- 2026Do Medical Vision Language Models Actually See? A Counterfactual Grounding Framework and Hard-Negative Contrastive Training for Visually-Reliant Medical VLMs
- 2026How Do Medical MLLMs Fail? A Study on Visual Grounding in Medical Images
- 2024SURE-VQA: Systematic Understanding of Robustness Evaluation in Medical VQA Tasks
- 2025Benchmarking and Mitigating Sycophancy in Medical Vision Language Models
- 2025CoTBox-TTT: Grounding Medical VQA with Visual Chain-of-Thought Boxes During Test-time Training