HERMES: A Unified Open-Source Framework for Realtime Multimodal Physiological Sensing, Edge AI, and Intervention in Closed-Loop Smart Healthcare Applications

Intelligent assistive technologies are increasingly recognized as critical daily-use enablers for people with disabilities and age-related functional decline. Longitudinal studies, curation of quality datasets, live monitoring in activities of daily living, and intelligent intervention devices, share the largely unsolved need in reliable high-throughput multimodal sensing and processing. Streaming large heterogeneous data from distributed sensors, historically closed-source environments, and limited prior works on realtime closed-loop AI methodologies, inhibit such applications. To accelerate the emergence of clinical deployments, we deliver HERMES - an open-source high-performance Python framework for continuous multimodal sensing and AI processing at the edge. It enables synchronized data collection, and realtime streaming inference with user PyTorch models, on commodity computing devices. HERMES is applicable to fixed-lab and free-living environments, of distributed commercial and custom sensors. It is the first work to offer a holistic methodology that bridges cross-disciplinary gaps in real-world implementation strategies, and guides downstream AI model development. Its application on the closed-loop intelligent prosthesis use case illustrates the process of suitable AI model development from the generated constraints and trade-offs. Validation on the use case, with 4 synchronized hosts cooperatively capturing 18 wearable and off-body modalities, demonstrates performance and relevance of HERMES to the trajectory of the intelligent healthcare domain.