SparseDoctor: Towards Efficient Chat Doctor with Mixture of Experts Enhanced Large Language Models
On the map: Mixture-of-experts → Medical and biomedical MoE
Abstract (arXiv)
Large language models (LLMs) have achieved great success in medical question answering and clinical decision-making, promoting the efficiency and popularization of the personalized virtual doctor in society. However, the traditional fine-tuning strategies on LLM require the updates of billions of parameters, substantially increasing the training cost, including the training time and utility cost. To enhance the efficiency and effectiveness of the current medical LLMs and explore the boundary of the representation capability of the LLMs on the medical domain, apart from the traditional fine-tuning strategies from the data perspective (i.e., supervised fine-tuning or reinforcement learning from human feedback), we instead craft a novel sparse medical LLM named SparseDoctor armed with contrastive learning enhanced LoRA-MoE (low rank adaptation-mixture of experts) architecture. To this end, the crafted automatic routing mechanism can scientifically allocate the computational resources among different LoRA experts supervised by the contrastive learning. Additionally, we also introduce a novel expert memory queue mechanism to further boost the efficiency of the overall framework and prevent the memory overflow during training. We conduct comprehensive evaluations on three typical medical benchmarks: CMB, CMExam, and CMMLU-Med. Experimental results demonstrate that the proposed LLM can consistently outperform the strong baselines such as the HuatuoGPT series.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Medical and biomedical MoE, one of 12 directions in Mixture-of-experts. Builds on 21 of its 40 references that are in the map. First posted on arXiv 15 Sep 2025.
Builds on
21 of 40 references.
References · 21
- 2023GPT-4 Technical Reportcited by 18,396
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- 2024MixLoRA: Enhancing Large Language Models Fine-Tuning with LoRA-based Mixture of Expertscited by 147
- 2023DoctorGLM: Fine-tuning your Chinese Doctor is not a Herculean Taskcited by 131
- 2023CMB: A Comprehensive Medical Benchmark in Chinesecited by 115
9 more
- 2023Mixture of Cluster-conditional LoRA Experts for Vision-language Instruction Tuningcited by 106
- 2023Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Datasetcited by 91
- 2023DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultationcited by 90
- 2023LoRAMoE: Alleviate World Knowledge Forgetting in Large Language Models via MoE-Style Plugincited by 82
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- 2024AcceLLM: Accelerating LLM Inference using Redundancy for Load Balancing and Data Localitycited by 1
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- 2024MING-MOE: Enhancing Medical Multi-Task Learning in Large Language Models with Sparse Mixture of Low-Rank Adapter Experts
- 2024The Limited Impact of Medical Adaptation of Large Language and Vision-Language Models
- 2025Generalization of Medical Large Language Models through Cross-Domain Weak Supervision
- 2025Collaboration among Multiple Large Language Models for Medical Question Answering
- 2024A Survey for Large Language Models in Biomedicine
- 2026MambaFormer: Token-Level Guided Routing Mixture-of-Experts for Accurate and Efficient Clinical Assistance
- 2023When MOE Meets LLMs: Parameter Efficient Fine-tuning for Multi-task Medical Applications
- 2025IMB: An Italian Medical Benchmark for Question Answering