mlsanityData to 7 Oct 2026

SePA: A Search-enhanced Predictive Agent for Personalized Health Coaching

arXiv 2509.04752 ↗First posted 5 Sep 2025cs.HC cs.AI cs.LGcited by 1

On the map: Retrieval-augmented generation → Medical and biomedical RAG

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Abstract (arXiv)

This paper introduces SePA (Search-enhanced Predictive AI Agent), a novel LLM health coaching system that integrates personalized machine learning and retrieval-augmented generation to deliver adaptive, evidence-based guidance. SePA combines: (1) Individualized models predicting daily stress, soreness, and injury risk from wearable sensor data (28 users, 1260 data points); and (2) A retrieval module that grounds LLM-generated feedback in expert-vetted web content to ensure contextual relevance and reliability. Our predictive models, evaluated with rolling-origin cross-validation and group k-fold cross-validation show that personalized models outperform generalized baselines. In a pilot expert study (n=4), SePA's retrieval-based advice was preferred over a non-retrieval baseline, yielding meaningful practical effect (Cliff's δ=0.3, p=0.05). We also quantify latency performance trade-offs between response quality and speed, offering a transparent blueprint for next-generation, trustworthy personal health informatics systems.

Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation. Builds on 6 of its 26 references that are in the map. First posted on arXiv 5 Sep 2025.

Builds on

6 of 26 references.

References · 6

  1. 2024Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Datacited by 65
  2. 2024GPTCoach: Towards LLM-Based Physical Activity Coachingcited by 29
  3. 2024Towards a Personal Health Large Language Modelcited by 25
  4. 2024PhysioLLM: Supporting Personalized Health Insights with Wearables and Large Language Modelscited by 16
  5. 2024Knowledge-Infused LLM-Powered Conversational Health Agent: A Case Study for Diabetes Patientscited by 9
  6. 2017Predictive modelling of training loads and injury in Australian footballcited by 2

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Citing papers per year: 2025: 1.

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  1. 2024Transforming Wearable Data into Personal Health Insights using Large Language Model Agents
  2. 2025The Anatomy of a Personal Health Agent
  3. 2024From Barriers to Tactics: A Behavioral Science-Informed Agentic Workflow for Personalized Nutrition Coaching
  4. 2024Graph-Augmented LLMs for Personalized Health Insights: A Case Study in Sleep Analysis
  5. 2026WEQA: Wearable hEalth Question Answering with Query-Adaptive Agentic Reasoning
  6. 2026A Multi-Agent LLM Framework for Personalized Health Checkup Interpretation and Guidance
  7. 2026Retrieval-Augmented Personalization with Foundation Models for Wearable Stress Detection
  8. 2025AdaptAI: A Personalized Solution to Sense Your Stress, Fix Your Mess, and Boost Productivity ↗