Causal MAS: A Survey of Large Language Model Architectures for Discovery and Effect Estimation
On the map: LLM agents and tool use → Medical and scientific domain agents
Abstract (arXiv)
Large Language Models (LLMs) have demonstrated remarkable capabilities in various reasoning and generation tasks. However, their proficiency in complex causal reasoning, discovery, and estimation remains an area of active development, often hindered by issues like hallucination, reliance on spurious correlations, and difficulties in handling nuanced, domain-specific, or personalized causal relationships. Multi-agent systems, leveraging the collaborative or specialized abilities of multiple LLM-based agents, are emerging as a powerful paradigm to address these limitations. This review paper explores the burgeoning field of causal multi-agent LLMs. We examine how these systems are designed to tackle different facets of causality, including causal reasoning and counterfactual analysis, causal discovery from data, and the estimation of causal effects. We delve into the diverse architectural patterns and interaction protocols employed, from pipeline-based processing and debate frameworks to simulation environments and iterative refinement loops. Furthermore, we discuss the evaluation methodologies, benchmarks, and diverse application domains where causal multi-agent LLMs are making an impact, including scientific discovery, healthcare, fact-checking, and personalized systems. Finally, we highlight the persistent challenges, open research questions, and promising future directions in this synergistic field, aiming to provide a comprehensive overview of its current state and potential trajectory.
Key facts. Cited by 2 papers in the map (data through 14 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 17 of its 29 references that are in the map. First posted on arXiv 31 Aug 2025.
Builds on
17 of 29 references.
Closest ancestors · 3
Same direction, newest first
- 2025Causal-Copilot: An Autonomous Causal Analysis Agent17 Apr
- 2024Language Agents Meet Causality -- Bridging LLMs and Causal World Models25 Oct
- 2024Multi-Agent Causal Discovery Using Large Language Models21 Jul
Other references · 14
- 2022ReAct: Synergizing Reasoning and Acting in Language Modelscited by 8,695
- 2023Causal Reasoning and Large Language Models: Opening a New Frontier for Causalitycited by 353
- 2023On Generative Agents in Recommendationcited by 90
- 2023Can large language models build causal graphs?cited by 73
- 2022LMPriors: Pre-Trained Language Models as Task-Specific Priorscited by 56
- 2022e-CARE: a New Dataset for Exploring Explainable Causal Reasoningcited by 47
- 2022Can Prompt Probe Pretrained Language Models? Understanding the Invisible Risks from a Causal Viewcited by 31
- 2022WikiWhy: Answering and Explaining Cause-and-Effect Questionscited by 21
- 2024Causal Evaluation of Language Modelscited by 18
- 2024Counterfactual Debating with Preset Stances for Hallucination Elimination of LLMscited by 17
- 2024Causal-Guided Active Learning for Debiasing Large Language Modelscited by 15
- 2024ADAM: An Embodied Causal Agent in Open-World Environmentscited by 13
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Citing papers per year: 2026: 2.
2 papers.
Similar, not cited
Close in wording, no citation either way
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- 2025Unveiling Causal Reasoning in Large Language Models: Reality or Mirage?
- 2026CausalDS: Benchmarking Causal Reasoning in Data-Science Agents
- 2026CausalGame: Benchmarking Causal Thinking of LLM Agents in Games
- 2023Enhancing Causal Reasoning in Large Language Models: A Causal Attribution Model for Precision Fine-Tuning