On the Robustness of Medical Vision-Language Models: Are they Truly Generalizable?
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
Medical Vision-Language Models (MVLMs) have achieved par excellence generalization in medical image analysis, yet their performance under noisy, corrupted conditions remains largely untested. Clinical imaging is inherently susceptible to acquisition artifacts and noise; however, existing evaluations predominantly assess generally clean datasets, overlooking robustness -- i.e., the model's ability to perform under real-world distortions. To address this gap, we first introduce MediMeta-C, a corruption benchmark that systematically applies several perturbations across multiple medical imaging datasets. Combined with MedMNIST-C, this establishes a comprehensive robustness evaluation framework for MVLMs. We further propose RobustMedCLIP, a visual encoder adaptation of a pretrained MVLM that incorporates few-shot tuning to enhance resilience against corruptions. Through extensive experiments, we benchmark 5 major MVLMs across 5 medical imaging modalities, revealing that existing models exhibit severe degradation under corruption and struggle with domain-modality tradeoffs. Our findings highlight the necessity of diverse training and robust adaptation strategies, demonstrating that efficient low-rank adaptation when paired with few-shot tuning, improves robustness while preserving generalization across modalities.
Key facts. Cited by 10 papers in the map (data through 14 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 23 of its 39 references that are in the map. First posted on arXiv 21 May 2025.
Builds on
23 of 39 references.
Closest ancestors · 1
Same direction, newest first
Other references · 22
- 2021Learning Transferable Visual Models From Natural Language Supervisioncited by 33,744
- 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,380
- 2019Benchmarking Neural Network Robustness to Common Corruptions and Perturbationscited by 2,877
- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,423
- 2019MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographscited by 597
- 2023BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairscited by 520
- 2023PMC-CLIP: Contrastive Language-Image Pre-training using Biomedical Documentscited by 212
- 2024A Comprehensive Survey of Foundation Models in Medicinecited by 56
- 2022MedFuse: Multi-modal fusion with clinical time-series data and chest X-ray imagescited by 54
- 2024ROCOv2: Radiology Objects in COntext Version 2, an Updated Multimodal Image Datasetcited by 54
- 2023CLIP in Medical Imaging: A Surveycited by 40
- 2020DCT-Mask: Discrete Cosine Transform Mask Representation for Instance Segmentationcited by 27
10 more
- 2024MedMNIST-C: Comprehensive benchmark and improved classifier robustness by simulating realistic image corruptionscited by 17
- 2024Test-Time Low Rank Adaptation via Confidence Maximization for Zero-Shot Generalization of Vision-Language Modelscited by 17
- 2024BAPLe: Backdoor Attacks on Medical Foundational Models using Prompt Learningcited by 16
- 2024A comprehensive and easy-to-use multi-domain multi-task medical imaging meta-datasetcited by 12
- 2024A Survey of Medical Vision-and-Language Applications and Their Techniquescited by 11
- 2018Pre and Post-hoc Diagnosis and Interpretation of Malignancy from Breast DCE-MRIcited by 7
- 2023Frequency Domain Adversarial Training for Robust Volumetric Medical Segmentationcited by 6
- 2025Noise is an Efficient Learner for Zero-Shot Vision-Language Modelscited by 6
- 2024On Evaluating Adversarial Robustness of Volumetric Medical Segmentation Modelscited by 2
- 2025Benchmarking Robustness of Contrastive Learning Models for Medical Image-Report Retrievalcited by 1
Built on by
Citing papers per year: 2025: 3; 2026: 7.
10 papers.
- 2025Reasoning Visual Language Model for Chest X-Ray Analysiscited by 8
- 2025Decoupling Clinical and Class-Agnostic Features for Reliable Few-Shot Adaptation under Shiftcited by 3
- 2025T3: Test-Time Model Merging in VLMs for Zero-Shot Medical Imaging Analysiscited by 2
- 2026The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomycited by 2
- 2026Stride-Net: Fairness-Aware Disentangled Representation Learning for Chest X-Ray Diagnosiscited by 1
- 2026Can Experts Adapt Without Training? On Test-Time Modality Generalization in MVLMscited by 1
- 2026MedQ-Deg: A Multidimensional Benchmark for Evaluating MLLMs Across Medical Image Quality Degradationscited by 0
- 2026Assessing VLM Reliability for Medical Image Quality Evaluation Under Corruption and Biascited by 0
- 2026Vertical Fusion: Condensing Internal Representations for Robust ViT Classificationcited by 0
- 2026On the Robustness of Temporal Vision-Language Models for Surgical Endoscopy Videoscited by 0
- 2026On the Robustness of Temporal Vision-Language Models for Surgical Endoscopy Videos14 Aug 2026
- 2026Can Experts Adapt Without Training? On Test-Time Modality Generalization in MVLMs18 Jul 2026
- 2026The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomy13 Jul 2026
- 2026Vertical Fusion: Condensing Internal Representations for Robust ViT Classification11 Jul 2026
- 2026Assessing VLM Reliability for Medical Image Quality Evaluation Under Corruption and Bias2 Jul 2026
- 2026MedQ-Deg: A Multidimensional Benchmark for Evaluating MLLMs Across Medical Image Quality Degradations8 Mar 2026
- 2026Stride-Net: Fairness-Aware Disentangled Representation Learning for Chest X-Ray Diagnosis11 Feb 2026
- 2025T3: Test-Time Model Merging in VLMs for Zero-Shot Medical Imaging Analysis31 Oct 2025
- 2025Reasoning Visual Language Model for Chest X-Ray Analysis28 Oct 2025
- 2025Decoupling Clinical and Class-Agnostic Features for Reliable Few-Shot Adaptation under Shift11 Sep 2025
Similar, not cited
Close in wording, no citation either way
- 2026CoDA: Exploring Chain-of-Distribution Attacks and Post-Hoc Token-Space Repair for Medical Vision-Language Models
- 2025Perceive and Calibrate: Analyzing and Enhancing Robustness of Medical Multi-Modal Large Language Models
- 2026Calibrated Triage, Not Autonomy: Confidence Estimation for Medical Vision-Language Models
- 2024PromptSmooth: Certifying Robustness of Medical Vision-Language Models via Prompt Learning
- 2025Taming Vision-Language Models for Medical Image Analysis: A Comprehensive Review
- 2025How Far Have Medical Vision-Language Models Come? A Comprehensive Benchmarking Study
- 2026Robust Pre-Training of Medical Vision-and-Language Models with Domain-Invariant Multi-Modal Masked Reconstruction
- 2026CADRE: Stable, Parameter Efficient Adaptation of Medical Vision Language Models with Bounded Forgetting and Prior Drift