T3: Test-Time Model Merging in VLMs for Zero-Shot Medical Imaging Analysis
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
In medical imaging, vision-language models face a critical duality: pretrained networks offer broad robustness but lack subtle, modality-specific characteristics, while fine-tuned expert models achieve high in-distribution accuracy yet falter under modality shift. Existing model-merging techniques, designed for natural-image benchmarks, are simple and efficient but fail to deliver consistent gains across diverse medical modalities; their static interpolation limits reliability in varied clinical tasks. To address this, we introduce Test-Time Task adaptive merging (T^3), a backpropagation-free framework that computes per-sample interpolation coefficients via the Jensen-Shannon divergence between the two models' output distributions. T^3 dynamically preserves local precision when models agree and defers to generalist robustness under drift. To overcome the inference costs of sample-wise merging, we further propose a batch-wise extension, T^3_B, that computes a merging coefficient across a batch of samples, dramatically reducing computational bottleneck. Recognizing the lack of a standardized medical-merging benchmark, we present a rigorous cross-evaluation protocol spanning in-domain, base-to-novel, and corruptions across four modalities. Empirically, T^3 sets new state-of-the-art in Top-1 accuracy and error reduction, outperforming strong baselines while maintaining efficiency, paving the way for adaptive MVLM deployment in clinical settings. Our code is available at https://github.com/Razaimam45/TCube.
Key facts. Cited by 2 papers in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 22 of its 33 references that are in the map. First posted on arXiv 31 Oct 2025.
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22 of 33 references.
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Other references · 21
- 2021Learning Transferable Visual Models From Natural Language Supervisioncited by 33,456
- 2019Benchmarking Neural Network Robustness to Common Corruptions and Perturbationscited by 2,857
- 2022Model soups: averaging weights of multiple fine-tuned models improves accuracy without increasing inference timecited by 1,366
- 2022Editing Models with Task Arithmeticcited by 1,076
- 2023TIES-Merging: Resolving Interference When Merging Modelscited by 795
- 2021Robust fine-tuning of zero-shot modelscited by 785
- 2022MedCLIP: Contrastive Learning from Unpaired Medical Images and Textcited by 564
- 2022Test-Time Prompt Tuning for Zero-Shot Generalization in Vision-Language Modelscited by 379
- 2023AdaMerging: Adaptive Model Merging for Multi-Task Learningcited by 248
- 2023Diverse Data Augmentation with Diffusions for Effective Test-time Prompt Tuningcited by 150
- 2024Twin-Merging: Dynamic Integration of Modular Expertise in Model Mergingcited by 114
- 2024EMR-Merging: Tuning-Free High-Performance Model Mergingcited by 108
9 more
- 2023Align Your Prompts: Test-Time Prompting with Distribution Alignment for Zero-Shot Generalizationcited by 100
- 2024On the test-time zero-shot generalization of vision-language models: Do we really need prompt learning?cited by 65
- 2020Stochastic Weight Averaging in Parallel: Large-Batch Training that Generalizes Wellcited by 57
- 2024DaWin: Training-free Dynamic Weight Interpolation for Robust Adaptationcited by 19
- 2024MedMNIST-C: Comprehensive benchmark and improved classifier robustness by simulating realistic image corruptionscited by 17
- 2024Test-Time Low Rank Adaptation via Confidence Maximization for Zero-Shot Generalization of Vision-Language Modelscited by 17
- 2024A comprehensive and easy-to-use multi-domain multi-task medical imaging meta-datasetcited by 12
- 2025Mixup Model Merge: Enhancing Model Merging Performance through Randomized Linear Interpolationcited by 2
- 2025In-Model Merging for Enhancing the Robustness of Medical Imaging Classification Modelscited by 1
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Citing papers per year: 2026: 2.
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- 2026When Can Test-Time Adaptation Help Zero-Shot CT Vision-Language Models?
- 2026BioMedVR: Confusion-Aware Mixture-of-Prompt Experts for Biomedical Visual Reprogramming
- 2025Few-Shot, Now for Real: Medical VLMs Adaptation without Balanced Sets or Validation
- 2026TCLA: Training-Free Class-wise Logit Adaptation for Medical Vision-Language Models
- 2025Full Conformal Adaptation of Medical Vision-Language Models
- 2025Taming Vision-Language Models for Medical Image Analysis: A Comprehensive Review