In defence of post-hoc explanations in medical AI
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Abstract (arXiv)
Since the early days of the Explainable AI movement, post-hoc explanations have been praised for their potential to improve user understanding, promote trust, and reduce patient safety risks in black box medical AI systems. Recently, however, critics have argued that the benefits of post-hoc explanations are greatly exaggerated since they merely approximate, rather than replicate, the actual reasoning processes that black box systems take to arrive at their outputs. In this article, we aim to defend the value of post-hoc explanations against this recent critique. We argue that even if post-hoc explanations do not replicate the exact reasoning processes of black box systems, they can still improve users' functional understanding of black box systems, increase the accuracy of clinician-AI teams, and assist clinicians in justifying their AI-informed decisions. While post-hoc explanations are not a "silver bullet" solution to the black box problem in medical AI, we conclude that they remain a useful strategy for addressing the black box problem in medical AI.
Key facts. Cited by 1 paper in the map (data through 14 Oct 2026). Builds on 19 of its 56 references that are in the map. First posted on arXiv 29 Apr 2025.
Builds on
19 of 56 references.
References · 19
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7 more
- 2022The Road to Explainability is Paved with Bias: Measuring the Fairness of Explanationscited by 41
- 2021Explanation of Machine Learning Models Using Shapley Additive Explanation and Application for Real Data in Hospitalcited by 17
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- 2024Explainable AI: Definition and attributes of a good explanation for health AI
- 2026Position: Explainability Research Must Prioritize Foundations over Ad-hoc Methods
- 2026Faithful or Just Plausible? Evaluating the Faithfulness of Closed-Source LLMs in Medical Reasoning
- 2023Diagrammatization and Abduction to Improve AI Interpretability With Domain-Aligned Explanations for Medical Diagnosis
- 2026Beyond Post-hoc Explanation: Toward Glassbox AI via Probabilistic Mediation
- 2025A Survey on Human-Centered Evaluation of Explainable AI Methods in Clinical Decision Support Systems