The Rise of Small Language Models in Healthcare: A Comprehensive Survey
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Abstract (arXiv)
Despite substantial progress in healthcare applications driven by large language models (LLMs), growing concerns around data privacy, and limited resources; the small language models (SLMs) offer a scalable and clinically viable solution for efficient performance in resource-constrained environments for next-generation healthcare informatics. Our comprehensive survey presents a taxonomic framework to identify and categorize them for healthcare professionals and informaticians. The timeline of healthcare SLM contributions establishes a foundational framework for analyzing models across three dimensions: NLP tasks, stakeholder roles, and the continuum of care. We present a taxonomic framework to identify the architectural foundations for building models from scratch; adapting SLMs to clinical precision through prompting, instruction fine-tuning, and reasoning; and accessibility and sustainability through compression techniques. Our primary objective is to offer a comprehensive survey for healthcare professionals, introducing recent innovations in model optimization and equipping them with curated resources to support future research and development in the field. Aiming to showcase the groundbreaking advancements in SLMs for healthcare, we present a comprehensive compilation of experimental results across widely studied NLP tasks in healthcare to highlight the transformative potential of SLMs in healthcare. The updated repository is available at Github
Key facts. Cited by 18 papers in the map (data through 14 Oct 2026). Builds on 123 of its 234 references that are in the map. First posted on arXiv 23 Apr 2025.
Builds on
123 of 234 references.
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Citing papers per year: 2025: 5; 2026: 13.
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- 2025Menta: A Small Language Model for On-Device Mental Health Predictioncited by 3
- 2026Automatic Prompt Optimization for Dataset-Level Feature Discoverycited by 3
- 2026LoopMTP: A looped transformer guided by latent multi-token predictioncited by 3
- 2026Reinforcement Learning Improves LLM Accuracy and Reasoning in Disease Classification from Radiology Reportscited by 2
- 2025Second Opinion Matters: Towards Adaptive Clinical AI via the Consensus of Expert Model Ensemblecited by 1
- 2026DepthWeave-KV: Token-Adaptive Cross-Layer Residual Factorization for Long-Context KV Cache Compressioncited by 1
- 2026Benchmarking the Benchmarks: Evaluating Automated Safety Benchmarks for Small Language Modelscited by 1
- 2025Small Language Models for Emergency Departments Decision Support: A Benchmark Studycited by 0
- 2025Dual-stage and Lightweight Patient Chart Summarization for Emergency Physicianscited by 0
- 2025Benchmarking and Adapting On-Device LLMs for Clinical Decision Supportcited by 0
- 2026Can Small Language Models Handle Context-Summarized Multi-Turn Customer-Service QA? A Synthetic Data-Driven Comparative Evaluationcited by 0
- 2026Small Language Models for Privacy-Preserving Clinical Information Extraction in Low-Resource Languagescited by 0
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- 2026FreqDepthKV: Frequency-Guided Depth Sharing for Robust KV Cache Compression in Long-Context LLM Inferencecited by 0
- 2026In-Context Learning for Wound Classification with Small Multimodal Language Modelscited by 0
- 2026HARISSA: Inference-Time Self-Checks for Efficient and Safe Local Language Model Deploymentcited by 0
- 2026HARISSA: Inference-Time Self-Checks for Efficient and Safe Local Language Model Deployment29 Sep 2026
- 2026Benchmarking the Benchmarks: Evaluating Automated Safety Benchmarks for Small Language Models17 Aug 2026
- 2026LoopMTP: A looped transformer guided by latent multi-token prediction4 Aug 2026
- 2026In-Context Learning for Wound Classification with Small Multimodal Language Models21 Jul 2026
- 2026DepthWeave-KV: Token-Adaptive Cross-Layer Residual Factorization for Long-Context KV Cache Compression7 Jul 2026
- 2026FreqDepthKV: Frequency-Guided Depth Sharing for Robust KV Cache Compression in Long-Context LLM Inference7 Jul 2026
- 2026TRACE: A taxonomy-grounded synthetic dataset for teaching-program generation and session interpretation in Applied Behavior Analysis24 May 2026
- 2026Wasserstein Equilibrium Decoding for Reliable Medical Visual Question Answering18 May 2026
- 2026Reinforcement Learning Improves LLM Accuracy and Reasoning in Disease Classification from Radiology Reports21 Apr 2026
- 2026Resource-Conscious Modeling for Next- Day Discharge Prediction Using Clinical Notes3 Apr 2026
- 2026Small Language Models for Privacy-Preserving Clinical Information Extraction in Low-Resource Languages24 Feb 2026
- 2026Can Small Language Models Handle Context-Summarized Multi-Turn Customer-Service QA? A Synthetic Data-Driven Comparative Evaluation31 Jan 2026
6 more
- 2026Automatic Prompt Optimization for Dataset-Level Feature Discovery20 Jan 2026
- 2025Benchmarking and Adapting On-Device LLMs for Clinical Decision Support18 Dec 2025
- 2025Menta: A Small Language Model for On-Device Mental Health Prediction2 Dec 2025
- 2025Dual-stage and Lightweight Patient Chart Summarization for Emergency Physicians5 Oct 2025
- 2025Small Language Models for Emergency Departments Decision Support: A Benchmark Study5 Oct 2025
- 2025Second Opinion Matters: Towards Adaptive Clinical AI via the Consensus of Expert Model Ensemble29 May 2025
- 2025Menta: A Small Language Model for On-Device Mental Health Predictioncited by 3
- 2026Automatic Prompt Optimization for Dataset-Level Feature Discoverycited by 3
- 2026LoopMTP: A looped transformer guided by latent multi-token predictioncited by 3
- 2025Second Opinion Matters: Towards Adaptive Clinical AI via the Consensus of Expert Model Ensemblecited by 1
- 2026Benchmarking the Benchmarks: Evaluating Automated Safety Benchmarks for Small Language Modelscited by 1
- 2025Small Language Models for Emergency Departments Decision Support: A Benchmark Studycited by 0
- 2025Dual-stage and Lightweight Patient Chart Summarization for Emergency Physicianscited by 0
- 2025Benchmarking and Adapting On-Device LLMs for Clinical Decision Supportcited by 0
- 2026Small Language Models for Privacy-Preserving Clinical Information Extraction in Low-Resource Languagescited by 0
- 2026Resource-Conscious Modeling for Next- Day Discharge Prediction Using Clinical Notescited by 0
- 2026TRACE: A taxonomy-grounded synthetic dataset for teaching-program generation and session interpretation in Applied Behavior Analysiscited by 0
- 2026HARISSA: Inference-Time Self-Checks for Efficient and Safe Local Language Model Deploymentcited by 0
- 2026HARISSA: Inference-Time Self-Checks for Efficient and Safe Local Language Model Deployment29 Sep 2026
- 2026Benchmarking the Benchmarks: Evaluating Automated Safety Benchmarks for Small Language Models17 Aug 2026
- 2026LoopMTP: A looped transformer guided by latent multi-token prediction4 Aug 2026
- 2026TRACE: A taxonomy-grounded synthetic dataset for teaching-program generation and session interpretation in Applied Behavior Analysis24 May 2026
- 2026Resource-Conscious Modeling for Next- Day Discharge Prediction Using Clinical Notes3 Apr 2026
- 2026Small Language Models for Privacy-Preserving Clinical Information Extraction in Low-Resource Languages24 Feb 2026
- 2026Automatic Prompt Optimization for Dataset-Level Feature Discovery20 Jan 2026
- 2025Benchmarking and Adapting On-Device LLMs for Clinical Decision Support18 Dec 2025
- 2025Menta: A Small Language Model for On-Device Mental Health Prediction2 Dec 2025
- 2025Dual-stage and Lightweight Patient Chart Summarization for Emergency Physicians5 Oct 2025
- 2025Small Language Models for Emergency Departments Decision Support: A Benchmark Study5 Oct 2025
- 2025Second Opinion Matters: Towards Adaptive Clinical AI via the Consensus of Expert Model Ensemble29 May 2025