Multi-Domain Graph Foundation Models: Robust Knowledge Transfer via Topology Alignment

Recent advances in CV and NLP have inspired researchers to develop general-purpose graph foundation models through pre-training across diverse domains. However, a fundamental challenge arises from the substantial differences in graph topologies across domains. Additionally, real-world graphs are often sparse and prone to noisy connections and adversarial attacks. To address these issues, we propose the Multi-Domain Graph Foundation Model (MDGFM), a unified framework that aligns and leverages cross-domain topological information to facilitate robust knowledge transfer. MDGFM bridges different domains by adaptively balancing features and topology while refining original graphs to eliminate noise and align topological structures. To further enhance knowledge transfer, we introduce an efficient prompt-tuning approach. By aligning topologies, MDGFM not only improves multi-domain pre-training but also enables robust knowledge transfer to unseen domains. Theoretical analyses provide guarantees of MDGFM's effectiveness and domain generalization capabilities. Extensive experiments on both homophilic and heterophilic graph datasets validate the robustness and efficacy of our method.