GTP-4o: Modality-prompted Heterogeneous Graph Learning for Omni-modal Biomedical Representation
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Abstract (arXiv)
Recent advances in learning multi-modal representation have witnessed the success in biomedical domains. While established techniques enable handling multi-modal information, the challenges are posed when extended to various clinical modalities and practical modalitymissing setting due to the inherent modality gaps. To tackle these, we propose an innovative Modality-prompted Heterogeneous Graph for Omnimodal Learning (GTP-4o), which embeds the numerous disparate clinical modalities into a unified representation, completes the deficient embedding of missing modality and reformulates the cross-modal learning with a graph-based aggregation. Specially, we establish a heterogeneous graph embedding to explicitly capture the diverse semantic properties on both the modality-specific features (nodes) and the cross-modal relations (edges). Then, we design a modality-prompted completion that enables completing the inadequate graph representation of missing modality through a graph prompting mechanism, which generates hallucination graphic topologies to steer the missing embedding towards the intact representation. Through the completed graph, we meticulously develop a knowledge-guided hierarchical cross-modal aggregation consisting of a global meta-path neighbouring to uncover the potential heterogeneous neighbors along the pathways driven by domain knowledge, and a local multi-relation aggregation module for the comprehensive cross-modal interaction across various heterogeneous relations. We assess the efficacy of our methodology on rigorous benchmarking experiments against prior state-of-the-arts. In a nutshell, GTP-4o presents an initial foray into the intriguing realm of embedding, relating and perceiving the heterogeneous patterns from various clinical modalities holistically via a graph theory. Project page: https://gtp-4-o.github.io/.
Key facts. Cited by 7 papers in the map (data through 7 Oct 2026). Builds on 47 of its 87 references that are in the map. First posted on arXiv 8 Jul 2024.
Builds on
47 of 87 references.
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35 more
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Built on by
Citing papers per year: 2024: 3; 2025: 2; 2026: 2.
7 papers.
- 2025Distilled Prompt Learning for Incomplete Multimodal Survival Predictioncited by 10
- 2024NuSegDG: Integration of Heterogeneous Space and Gaussian Kernel for Domain-Generalized Nuclei Segmentationcited by 5
- 2024When 3D Partial Points Meets SAM: Tooth Point Cloud Segmentation with Sparse Labelscited by 5
- 2024HeGraphAdapter: Tuning Multi-Modal Vision-Language Models with Heterogeneous Graph Adaptercited by 3
- 2026Beyond Sparse Supervision: Diffusion-Guided Learning for Few-Shot Graph Fraud Detectioncited by 2
- 2025DG-STMTL: A Novel Graph Convolutional Network for Multi-Task Spatio-Temporal Traffic Forecastingcited by 0
- 2026FU-Mamba: A Frequency-Enhanced Dynamic Scanning Framework for Oralscan Image Segmentationcited by 0
- 2026FU-Mamba: A Frequency-Enhanced Dynamic Scanning Framework for Oralscan Image Segmentation27 Aug 2026
- 2026Beyond Sparse Supervision: Diffusion-Guided Learning for Few-Shot Graph Fraud Detection26 Jun 2026
- 2025DG-STMTL: A Novel Graph Convolutional Network for Multi-Task Spatio-Temporal Traffic Forecasting10 Apr 2025
- 2025Distilled Prompt Learning for Incomplete Multimodal Survival Prediction3 Mar 2025
- 2024HeGraphAdapter: Tuning Multi-Modal Vision-Language Models with Heterogeneous Graph Adapter10 Oct 2024
- 2024When 3D Partial Points Meets SAM: Tooth Point Cloud Segmentation with Sparse Labels3 Sep 2024
- 2024NuSegDG: Integration of Heterogeneous Space and Gaussian Kernel for Domain-Generalized Nuclei Segmentation21 Aug 2024