PATIENT-Psi: Using Large Language Models to Simulate Patients for Training Mental Health Professionals
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Abstract (arXiv)
Mental illness remains one of the most critical public health issues. Despite its importance, many mental health professionals highlight a disconnect between their training and actual real-world patient practice. To help bridge this gap, we propose PATIENT-Psi, a novel patient simulation framework for cognitive behavior therapy (CBT) training. To build PATIENT-Psi, we construct diverse patient cognitive models based on CBT principles and use large language models (LLMs) programmed with these cognitive models to act as a simulated therapy patient. We propose an interactive training scheme, PATIENT-Psi-TRAINER, for mental health trainees to practice a key skill in CBT -- formulating the cognitive model of the patient -- through role-playing a therapy session with PATIENT-Psi. To evaluate PATIENT-Psi, we conducted a comprehensive user study of 13 mental health trainees and 20 experts. The results demonstrate that practice using PATIENT-Psi-TRAINER enhances the perceived skill acquisition and confidence of the trainees beyond existing forms of training such as textbooks, videos, and role-play with non-patients. Based on the experts' perceptions, PATIENT-Psi is perceived to be closer to real patient interactions than GPT-4, and PATIENT-Psi-TRAINER holds strong promise to improve trainee competencies. Our code and data are released at urlhttps://github.com/ruiyiw/patient-psi.
Key facts. Cited by 19 papers in the map (data through 7 Oct 2026). Builds on 18 of its 59 references that are in the map. First posted on arXiv 30 May 2024.
Builds on
18 of 59 references.
References · 18
- 2023GPT-4 Technical Reportcited by 18,132
- 2023Sparks of Artificial General Intelligence: Early experiments with GPT-4cited by 2,579
- 2023Can Large Language Models Be an Alternative to Human Evaluations?cited by 729
- 2023Can Large Language Models Transform Computational Social Science?cited by 245
- 2020A Computational Approach to Understanding Empathy Expressed in Text-Based Mental Health Supportcited by 182
- 2021MentalBERT: Publicly Available Pretrained Language Models for Mental Healthcarecited by 159
- 2024SOTOPIA-π: Interactive Learning of Socially Intelligent Language Agentscited by 89
- 2023Cognitive Reframing of Negative Thoughts through Human-Language Model Interactioncited by 77
- 2024A Computational Framework for Behavioral Assessment of LLM Therapistscited by 61
- 2023Facilitating Self-Guided Mental Health Interventions Through Human-Language Model Interaction: A Case Study of Cognitive Restructuringcited by 53
- 2023CLASS: A Design Framework for building Intelligent Tutoring Systems based on Learning Science principlescited by 46
- 2023Empowering Psychotherapy with Large Language Models: Cognitive Distortion Detection through Diagnosis of Thought Promptingcited by 31
6 more
- 2023Enhancing Psychological Counseling with Large Language Model: A Multifaceted Decision-Support System for Non-Professionalscited by 24
- 2023Helping the Helper: Supporting Peer Counselors via AI-Empowered Practice and Feedbackcited by 23
- 2020Engagement Patterns of Peer-to-Peer Interactions on Mental Health Platformscited by 16
- 2024Social Skill Training with Large Language Modelscited by 13
- 2024IMBUE: Improving Interpersonal Effectiveness through Simulation and Just-in-time Feedback with Human-Language Model Interactioncited by 12
- 2022EmoMent: An Emotion Annotated Mental Health Corpus from two South Asian Countriescited by 7
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Citing papers per year: 2024: 4; 2025: 13; 2026: 2.
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- 2025LLM Generated Persona is a Promise with a Catchcited by 77
- 2024TeachTune: Reviewing Pedagogical Agents Against Diverse Student Profiles with Simulated Studentscited by 25
- 2025EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safetycited by 21
- 2025Technological folie `a deux: Feedback Loops Between AI Chatbots and Mental Illnesscited by 14
- 2025MetaMind: Modeling Human Social Thoughts with Metacognitive Multi-Agent Systemscited by 12
- 2026MedDialogRubrics: A Comprehensive Benchmark and Evaluation Framework for Multi-turn Medical Consultations in Large Language Modelscited by 12
- 2025MindEval: Benchmarking Language Models on Multi-turn Mental Health Supportcited by 9
- 2025How Strategic Agents Respond: Comparing Analytical Models with LLM-Generated Responses in Strategic Classificationcited by 4
- 2024MentalArena: Self-play Training of Language Models for Diagnosis and Treatment of Mental Health Disorderscited by 1
- 2024Quantifying Risk Propensities of Large Language Models: Ethical Focus and Bias Detection through Role-Playcited by 1
- 2025Free Lunch for User Experience: Crowdsourcing Agents for Scalable User Studiescited by 1
- 2025DS@GT at eRisk 2025: From prompts to predictions, benchmarking early depression detection with conversational agent based assessments and temporal attention modelscited by 1
7 more
- 2025From Medical Records to Diagnostic Dialogues: A Clinical-Grounded Approach and Dataset for Psychiatric Comorbiditycited by 1
- 2026TherapyGym: Evaluating and Aligning Clinical Fidelity and Safety in Therapy Chatbotscited by 1
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counselingcited by 0
- 2025When and How to Integrate Multimodal Large Language Models in College Psychotherapy: Perspectives from Multi-stakeholderscited by 0
- 2025First, Do No Harm: AI Supervisor Scaffolds Novice Growth in Counselor Educationcited by 0
- 2025A Voice-Enabled Virtual Patient System for Interactive Training in Standardized Clinical Assessmentcited by 0
- 2025Can we use LLMs to bootstrap reinforcement learning? -- A case study in digital health behavior changecited by 0
- 2026TherapyGym: Evaluating and Aligning Clinical Fidelity and Safety in Therapy Chatbots23 Feb 2026
- 2026MedDialogRubrics: A Comprehensive Benchmark and Evaluation Framework for Multi-turn Medical Consultations in Large Language Models6 Jan 2026
- 2025MindEval: Benchmarking Language Models on Multi-turn Mental Health Support23 Nov 2025
- 2025Can we use LLMs to bootstrap reinforcement learning? -- A case study in digital health behavior change19 Nov 2025
- 2025A Voice-Enabled Virtual Patient System for Interactive Training in Standardized Clinical Assessment1 Nov 2025
- 2025From Medical Records to Diagnostic Dialogues: A Clinical-Grounded Approach and Dataset for Psychiatric Comorbidity29 Oct 2025
- 2025First, Do No Harm: AI Supervisor Scaffolds Novice Growth in Counselor Education12 Aug 2025
- 2025Technological folie `a deux: Feedback Loops Between AI Chatbots and Mental Illness25 Jul 2025
- 2025DS@GT at eRisk 2025: From prompts to predictions, benchmarking early depression detection with conversational agent based assessments and temporal attention models15 Jul 2025
- 2025Free Lunch for User Experience: Crowdsourcing Agents for Scalable User Studies29 May 2025
- 2025MetaMind: Modeling Human Social Thoughts with Metacognitive Multi-Agent Systems25 May 2025
- 2025EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safety13 Apr 2025
7 more
- 2025LLM Generated Persona is a Promise with a Catch18 Mar 2025
- 2025When and How to Integrate Multimodal Large Language Models in College Psychotherapy: Perspectives from Multi-stakeholders1 Feb 2025
- 2025How Strategic Agents Respond: Comparing Analytical Models with LLM-Generated Responses in Strategic Classification20 Jan 2025
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counseling29 Oct 2024
- 2024Quantifying Risk Propensities of Large Language Models: Ethical Focus and Bias Detection through Role-Play26 Oct 2024
- 2024MentalArena: Self-play Training of Language Models for Diagnosis and Treatment of Mental Health Disorders9 Oct 2024
- 2024TeachTune: Reviewing Pedagogical Agents Against Diverse Student Profiles with Simulated Students5 Oct 2024
- 2024TeachTune: Reviewing Pedagogical Agents Against Diverse Student Profiles with Simulated Studentscited by 25
- 2025How Strategic Agents Respond: Comparing Analytical Models with LLM-Generated Responses in Strategic Classificationcited by 4
- 2025Free Lunch for User Experience: Crowdsourcing Agents for Scalable User Studiescited by 1
- 2025DS@GT at eRisk 2025: From prompts to predictions, benchmarking early depression detection with conversational agent based assessments and temporal attention modelscited by 1
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counselingcited by 0
- 2025DS@GT at eRisk 2025: From prompts to predictions, benchmarking early depression detection with conversational agent based assessments and temporal attention models15 Jul 2025
- 2025Free Lunch for User Experience: Crowdsourcing Agents for Scalable User Studies29 May 2025
- 2025How Strategic Agents Respond: Comparing Analytical Models with LLM-Generated Responses in Strategic Classification20 Jan 2025
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counseling29 Oct 2024
- 2024TeachTune: Reviewing Pedagogical Agents Against Diverse Student Profiles with Simulated Students5 Oct 2024
- 2025LLM Generated Persona is a Promise with a Catchcited by 77
- 2025EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safetycited by 21
- 2025Technological folie `a deux: Feedback Loops Between AI Chatbots and Mental Illnesscited by 14
- 2026MedDialogRubrics: A Comprehensive Benchmark and Evaluation Framework for Multi-turn Medical Consultations in Large Language Modelscited by 12
- 2025MindEval: Benchmarking Language Models on Multi-turn Mental Health Supportcited by 9
- 2024Quantifying Risk Propensities of Large Language Models: Ethical Focus and Bias Detection through Role-Playcited by 1
- 2025From Medical Records to Diagnostic Dialogues: A Clinical-Grounded Approach and Dataset for Psychiatric Comorbiditycited by 1
- 2026TherapyGym: Evaluating and Aligning Clinical Fidelity and Safety in Therapy Chatbotscited by 1
- 2025First, Do No Harm: AI Supervisor Scaffolds Novice Growth in Counselor Educationcited by 0
- 2025A Voice-Enabled Virtual Patient System for Interactive Training in Standardized Clinical Assessmentcited by 0
- 2026TherapyGym: Evaluating and Aligning Clinical Fidelity and Safety in Therapy Chatbots23 Feb 2026
- 2026MedDialogRubrics: A Comprehensive Benchmark and Evaluation Framework for Multi-turn Medical Consultations in Large Language Models6 Jan 2026
- 2025MindEval: Benchmarking Language Models on Multi-turn Mental Health Support23 Nov 2025
- 2025A Voice-Enabled Virtual Patient System for Interactive Training in Standardized Clinical Assessment1 Nov 2025
- 2025From Medical Records to Diagnostic Dialogues: A Clinical-Grounded Approach and Dataset for Psychiatric Comorbidity29 Oct 2025
- 2025First, Do No Harm: AI Supervisor Scaffolds Novice Growth in Counselor Education12 Aug 2025
- 2025Technological folie `a deux: Feedback Loops Between AI Chatbots and Mental Illness25 Jul 2025
- 2025EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safety13 Apr 2025
- 2025LLM Generated Persona is a Promise with a Catch18 Mar 2025
- 2024Quantifying Risk Propensities of Large Language Models: Ethical Focus and Bias Detection through Role-Play26 Oct 2024