HC-Mamba: Vision MAMBA with Hybrid Convolutional Techniques for Medical Image Segmentation
On the map: State-space sequence models (S4, Mamba) → Mamba for medical image analysis
Abstract (arXiv)
Automatic medical image segmentation technology has the potential to expedite pathological diagnoses, thereby enhancing the efficiency of patient care. However, medical images often have complex textures and structures, and the models often face the problem of reduced image resolution and information loss due to downsampling. To address this issue, we propose HC-Mamba, a new medical image segmentation model based on the modern state space model Mamba. Specifically, we introduce the technique of dilated convolution in the HC-Mamba model to capture a more extensive range of contextual information without increasing the computational cost by extending the perceptual field of the convolution kernel. In addition, the HC-Mamba model employs depthwise separable convolutions, significantly reducing the number of parameters and the computational power of the model. By combining dilated convolution and depthwise separable convolutions, HC-Mamba is able to process large-scale medical image data at a much lower computational cost while maintaining a high level of performance. We conduct comprehensive experiments on segmentation tasks including organ segmentation and skin lesion, and conduct extensive experiments on Synapse, ISIC17 and ISIC18 to demonstrate the potential of the HC-Mamba model in medical image segmentation. The experimental results show that HC-Mamba exhibits competitive performance on all these datasets, thereby proving its effectiveness and usefulness in medical image segmentation.
Key facts. Cited by 15 papers in the map (data through 14 Oct 2026). Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba). Builds on 21 of its 26 references that are in the map. First posted on arXiv 8 May 2024.
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- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 30,186
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,713
- 2021Swin Transformer: Hierarchical Vision Transformer using Shifted Windowscited by 12,139
- 2023Mamba: Linear-Time Sequence Modeling with Selective State Spacescited by 4,718
- 2016Xception: Deep Learning with Depthwise Separable Convolutionscited by 2,332
- 2016V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentationcited by 2,292
- 2021TransUNet: Transformers Make Strong Encoders for Medical Image Segmentationcited by 1,558
- 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,525
- 2018Attention U-Net: Learning Where to Look for the Pancreascited by 1,435
- 2021Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentationcited by 1,222
- 2017A Survey on Deep Learning in Medical Image Analysiscited by 1,186
- 2015Multi-Scale Context Aggregation by Dilated Convolutionscited by 1,133
8 more
- 2019Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)cited by 669
- 2022Hungry Hungry Hippos: Towards Language Modeling with State Space Modelscited by 499
- 2021TransFuse: Fusing Transformers and CNNs for Medical Image Segmentationcited by 258
- 2022It's Raw! Audio Generation with State-Space Modelscited by 171
- 2023ChatCAD: Interactive Computer-Aided Diagnosis on Medical Image using Large Language Modelscited by 116
- 2021Shallow Attention Network for Polyp Segmentationcited by 107
- 2021Recent advances and clinical applications of deep learning in medical image analysiscited by 104
- 2022MALUNet: A Multi-Attention and Light-weight UNet for Skin Lesion Segmentationcited by 59
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Citing papers per year: 2024: 5; 2025: 5; 2026: 5.
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- 2024Mamba in Vision: A Comprehensive Survey of Techniques and Applicationscited by 18
- 2024A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyondcited by 16
- 2024SliceMamba with Neural Architecture Search for Medical Image Segmentationcited by 11
- 2025Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentationcited by 7
- 2025Merging Context Clustering with Visual State Space Models for Medical Image Segmentationcited by 4
- 2024Med-TTT: Vision Test-Time Training model for Medical Image Segmentationcited by 3
- 2026Na-IRSTD: Enhancing Infrared Small Target Detection via Native-Resolution Feature Selection and Fusioncited by 1
- 2024FAN-Unet: Enhancing Unet with vision Fourier Analysis Block for Biomedical Image Segmentationcited by 0
- 2025MedSegNet10: A Publicly Accessible Network Repository for Split Federated Medical Image Segmentationcited by 0
- 2025ACM-UNet: Adaptive Integration of CNNs and Mamba for Efficient Medical Image Segmentationcited by 0
- 2025WDFFU-Mamba: A Wavelet-guided Dual-attention Feature Fusion Mamba for Breast Tumor Segmentation in Ultrasound Imagescited by 0
- 2026DB-MSMUNet:Dual Branch Multi-scale Mamba UNet for Pancreatic CT Scans Segmentationcited by 0
3 more
- 2026Decoding Matters: Efficient Mamba-Based Decoder with Distribution-Aware Deep Supervision for Medical Image Segmentationcited by 0
- 2026CS-MUNet: A Channel-Spatial Dual-Stream Mamba Network for Multi-Organ Segmentationcited by 0
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigmscited by 0
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026Na-IRSTD: Enhancing Infrared Small Target Detection via Native-Resolution Feature Selection and Fusion7 May 2026
- 2026CS-MUNet: A Channel-Spatial Dual-Stream Mamba Network for Multi-Organ Segmentation20 Mar 2026
- 2026Decoding Matters: Efficient Mamba-Based Decoder with Distribution-Aware Deep Supervision for Medical Image Segmentation13 Mar 2026
- 2026DB-MSMUNet:Dual Branch Multi-scale Mamba UNet for Pancreatic CT Scans Segmentation8 Jan 2026
- 2025WDFFU-Mamba: A Wavelet-guided Dual-attention Feature Fusion Mamba for Breast Tumor Segmentation in Ultrasound Images19 Dec 2025
- 2025ACM-UNet: Adaptive Integration of CNNs and Mamba for Efficient Medical Image Segmentation30 May 2025
- 2025Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentation24 Apr 2025
- 2025MedSegNet10: A Publicly Accessible Network Repository for Split Federated Medical Image Segmentation26 Mar 2025
- 2025Merging Context Clustering with Visual State Space Models for Medical Image Segmentation3 Jan 2025
- 2024FAN-Unet: Enhancing Unet with vision Fourier Analysis Block for Biomedical Image Segmentation28 Nov 2024
- 2024Mamba in Vision: A Comprehensive Survey of Techniques and Applications4 Oct 2024
3 more
- 2024Med-TTT: Vision Test-Time Training model for Medical Image Segmentation3 Oct 2024
- 2024A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyond3 Oct 2024
- 2024SliceMamba with Neural Architecture Search for Medical Image Segmentation11 Jul 2024
- 2024Mamba in Vision: A Comprehensive Survey of Techniques and Applicationscited by 18
- 2024A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyondcited by 16
- 2024SliceMamba with Neural Architecture Search for Medical Image Segmentationcited by 11
- 2025Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentationcited by 7
- 2025ACM-UNet: Adaptive Integration of CNNs and Mamba for Efficient Medical Image Segmentationcited by 0
- 2025WDFFU-Mamba: A Wavelet-guided Dual-attention Feature Fusion Mamba for Breast Tumor Segmentation in Ultrasound Imagescited by 0
- 2026DB-MSMUNet:Dual Branch Multi-scale Mamba UNet for Pancreatic CT Scans Segmentationcited by 0
- 2026Decoding Matters: Efficient Mamba-Based Decoder with Distribution-Aware Deep Supervision for Medical Image Segmentationcited by 0
- 2026CS-MUNet: A Channel-Spatial Dual-Stream Mamba Network for Multi-Organ Segmentationcited by 0
- 2026CS-MUNet: A Channel-Spatial Dual-Stream Mamba Network for Multi-Organ Segmentation20 Mar 2026
- 2026Decoding Matters: Efficient Mamba-Based Decoder with Distribution-Aware Deep Supervision for Medical Image Segmentation13 Mar 2026
- 2026DB-MSMUNet:Dual Branch Multi-scale Mamba UNet for Pancreatic CT Scans Segmentation8 Jan 2026
- 2025WDFFU-Mamba: A Wavelet-guided Dual-attention Feature Fusion Mamba for Breast Tumor Segmentation in Ultrasound Images19 Dec 2025
- 2025ACM-UNet: Adaptive Integration of CNNs and Mamba for Efficient Medical Image Segmentation30 May 2025
- 2025Mamba-Sea: A Mamba-based Framework with Global-to-Local Sequence Augmentation for Generalizable Medical Image Segmentation24 Apr 2025
- 2024Mamba in Vision: A Comprehensive Survey of Techniques and Applications4 Oct 2024
- 2024A Comprehensive Survey of Mamba Architectures for Medical Image Analysis: Classification, Segmentation, Restoration and Beyond3 Oct 2024
- 2024SliceMamba with Neural Architecture Search for Medical Image Segmentation11 Jul 2024
- 2025Merging Context Clustering with Visual State Space Models for Medical Image Segmentationcited by 4
- 2024Med-TTT: Vision Test-Time Training model for Medical Image Segmentationcited by 3
- 2026Na-IRSTD: Enhancing Infrared Small Target Detection via Native-Resolution Feature Selection and Fusioncited by 1
- 2024FAN-Unet: Enhancing Unet with vision Fourier Analysis Block for Biomedical Image Segmentationcited by 0
- 2025MedSegNet10: A Publicly Accessible Network Repository for Split Federated Medical Image Segmentationcited by 0
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigmscited by 0
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026Na-IRSTD: Enhancing Infrared Small Target Detection via Native-Resolution Feature Selection and Fusion7 May 2026
- 2025MedSegNet10: A Publicly Accessible Network Repository for Split Federated Medical Image Segmentation26 Mar 2025
- 2025Merging Context Clustering with Visual State Space Models for Medical Image Segmentation3 Jan 2025
- 2024FAN-Unet: Enhancing Unet with vision Fourier Analysis Block for Biomedical Image Segmentation28 Nov 2024
- 2024Med-TTT: Vision Test-Time Training model for Medical Image Segmentation3 Oct 2024
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- 2025MambaCAFU: Hybrid Multi-Scale and Multi-Attention Model with Mamba-Based Fusion for Medical Image Segmentation
- 2024MambaClinix: Hierarchical Gated Convolution and Mamba-Based U-Net for Enhanced 3D Medical Image Segmentation
- 2024Mamba-UNet: UNet-Like Pure Visual Mamba for Medical Image Segmentation
- 2025A Comprehensive Analysis of Mamba for 3D Volumetric Medical Image Segmentation
- 2024CAMS: Convolution and Attention-Free Mamba-based Cardiac Image Segmentation
- 2024MSVM-UNet: Multi-Scale Vision Mamba UNet for Medical Image Segmentation
- 2025InceptionMamba: Efficient Multi-Stage Feature Enhancement with Selective State Space Model for Microscopic Medical Image Segmentation