Generative AI-Driven Human Digital Twin in IoT-Healthcare: A Comprehensive Survey
Not on the map. Why?
Abstract (arXiv)
The Internet of things (IoT) can significantly enhance the quality of human life, specifically in healthcare, attracting extensive attentions to IoT-healthcare services. Meanwhile, the human digital twin (HDT) is proposed as an innovative paradigm that can comprehensively characterize the replication of the individual human body in the digital world and reflect its physical status in real time. Naturally, HDT is envisioned to empower IoT-healthcare beyond the application of healthcare monitoring by acting as a versatile and vivid human digital testbed, simulating the outcomes and guiding the practical treatments. However, successfully establishing HDT requires high-fidelity virtual modeling and strong information interactions but possibly with scarce, biased and noisy data. Fortunately, a recent popular technology called generative artificial intelligence (GAI) may be a promising solution because it can leverage advanced AI algorithms to automatically create, manipulate, and modify valuable while diverse data. This survey particularly focuses on the implementation of GAI-driven HDT in IoT-healthcare. We start by introducing the background of IoT-healthcare and the potential of GAI-driven HDT. Then, we delve into the fundamental techniques and present the overall framework of GAI-driven HDT. After that, we explore the realization of GAI-driven HDT in detail, including GAI-enabled data acquisition, communication, data management, digital modeling, and data analysis. Besides, we discuss typical IoT-healthcare applications that can be revolutionized by GAI-driven HDT, namely personalized health monitoring and diagnosis, personalized prescription, and personalized rehabilitation. Finally, we conclude this survey by highlighting some future research directions.
Key facts. Cited by 11 papers in the map (data through 7 Oct 2026). Builds on 72 of its 196 references that are in the map. First posted on arXiv 22 Jan 2024.
Builds on
72 of 196 references.
References · 72
- 2017Attention Is All You Needcited by 59,932
- 2018BERT: Pre-training of Deep Bidirectional Transformers for Language Understandingcited by 40,204
- 2019RoBERTa: A Robustly Optimized BERT Pretraining Approachcited by 13,266
- 2020Score-Based Generative Modeling through Stochastic Differential Equationscited by 8,964
- 2018A Style-Based Generator Architecture for Generative Adversarial Networkscited by 5,986
- 2023Adding Conditional Control to Text-to-Image Diffusion Modelscited by 5,466
- 2016Image-to-Image Translation with Conditional Adversarial Networkscited by 4,510
- 2019DistilBERT, a distilled version of BERT: smaller, faster, cheaper and lightercited by 4,243
- 2018Large Scale GAN Training for High Fidelity Natural Image Synthesiscited by 2,609
- 2017Improved Training of Wasserstein GANscited by 2,223
- 2015Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networkscited by 2,048
- 2016Density estimation using Real NVPcited by 2,029
38 more
- 2019BioBERT: a pre-trained biomedical language representation model for biomedical text miningcited by 1,935
- 2021Image Super-Resolution via Iterative Refinementcited by 1,506
- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
- 2017High-Resolution Image Synthesis and Semantic Manipulation with Conditional GANscited by 1,176
- 2019An Introduction to Variational Autoencoderscited by 997
- 2017Generative Adversarial Networks: An Overviewcited by 588
- 2023Faster Segment Anything: Towards Lightweight SAM for Mobile Applicationscited by 345
- 2017Learning to Discover Cross-Domain Relations with Generative Adversarial Networkscited by 278
- 2022Diffusion Models for Medical Image Analysis: A Comprehensive Surveycited by 269
- 2021Deep Generative Modelling: A Comparative Review of VAEs, GANs, Normalizing Flows, Energy-Based and Autoregressive Modelscited by 251
- 2018Differentially Private Generative Adversarial Networkcited by 235
- 2018The relativistic discriminator: a key element missing from standard GANcited by 234
- 2022Diffusion Models for Medical Anomaly Detectioncited by 231
- 2017Generating Multi-label Discrete Patient Records using Generative Adversarial Networkscited by 197
- 2022Diffusion-based Time Series Imputation and Forecasting with Structured State Space Modelscited by 195
- 2021Noise2Score: Tweedie's Approach to Self-Supervised Image Denoising without Clean Imagescited by 110
- 2023Avatars Grow Legs: Generating Smooth Human Motion from Sparse Tracking Inputs with Diffusion Modelcited by 104
- 2019Missing MRI Pulse Sequence Synthesis using Multi-Modal Generative Adversarial Networkcited by 98
- 2022Semantic Communications for Future Internet: Fundamentals, Applications, and Challengescited by 94
- 2023Ambiguous Medical Image Segmentation using Diffusion Modelscited by 92
- 2020Hi-Net: Hybrid-fusion Network for Multi-modal MR Image Synthesiscited by 86
- 2018GANs for Medical Image Analysiscited by 81
- 2023Unleashing the Power of Edge-Cloud Generative AI in Mobile Networks: A Survey of AIGC Servicescited by 76
- 2022A Morphology Focused Diffusion Probabilistic Model for Synthesis of Histopathology Imagescited by 74
- 2022Conversion Between CT and MRI Images Using Diffusion and Score-Matching Modelscited by 69
- 2023AI-Generated Content (AIGC): A Surveycited by 59
- 2022PET image denoising based on denoising diffusion probabilistic modelscited by 57
- 2022SADM: Sequence-Aware Diffusion Model for Longitudinal Medical Image Generationcited by 56
- 2022Diffusion Adversarial Representation Learning for Self-supervised Vessel Segmentationcited by 55
- 2023DDM2: Self-Supervised Diffusion MRI Denoising with Generative Diffusion Modelscited by 50
- 2023Generative Semantic Communication: Diffusion Models Beyond Bit Recoverycited by 41
- 2023Generative AI-driven Semantic Communication Networks: Architecture, Technologies and Applicationscited by 36
- 2023Diffusion-based Conditional ECG Generation with Structured State Space Modelscited by 35
- 2023Diffusion-based Reinforcement Learning for Edge-enabled AI-Generated Content Servicescited by 33
- 2019PathologyGAN: Learning deep representations of cancer tissuecited by 32
- 2020SimGANs: Simulator-Based Generative Adversarial Networks for ECG Synthesis to Improve Deep ECG Classificationcited by 32
- 2022A Novel Unified Conditional Score-based Generative Framework for Multi-modal Medical Image Completioncited by 23
- 2023AI-Generated Incentive Mechanism and Full-Duplex Semantic Communications for Information Sharingcited by 21
50 most cited of 72 All 72 (JSON)
Built on by
Citing papers per year: 2024: 2; 2025: 6; 2026: 3.
11 papers.
- 2025Generative Diffusion Models for Wireless Networks: Fundamental, Architecture, and State-of-the-Artcited by 13
- 2024Hybrid RAG-empowered Multi-modal LLM for Secure Data Management in Internet of Medical Things: A Diffusion-based Contract Approachcited by 7
- 2025Mitigating Catastrophic Forgetting with Adaptive Transformer Block Expansion in Federated Fine-Tuningcited by 7
- 2025"X of Information'' Continuum: A Survey on AI-Driven Multi-dimensional Metrics for Next-Generation Networked Systemscited by 7
- 2025Diffusion Models for Future Networks and Communications: A Comprehensive Surveycited by 6
- 2025Generative Artificial Intelligence for Internet of Things Computing: A Systematic Surveycited by 3
- 2025Future You: Designing and Evaluating Multimodal AI-generated Digital Twins for Strengthening Future Self-Continuitycited by 2
- 2024Sustainable Diffusion-based Incentive Mechanism for Generative AI-driven Digital Twins in Industrial Cyber-Physical Systemscited by 1
- 2026Proof of Reasoning for Privacy Enhanced Federated Blockchain Learning at the Edgecited by 1
- 2026CalTwin: Towards Calibrated, Shift-Robust Medical World Models via Fisher-Information Regularisationcited by 1
- 2026PsyAgent: Constructing Human-like Agents Based on Psychological Modeling and Contextual Interactioncited by 0
- 2026CalTwin: Towards Calibrated, Shift-Robust Medical World Models via Fisher-Information Regularisation29 Jul 2026
- 2026Proof of Reasoning for Privacy Enhanced Federated Blockchain Learning at the Edge12 Jan 2026
- 2026PsyAgent: Constructing Human-like Agents Based on Psychological Modeling and Contextual Interaction6 Jan 2026
- 2025Future You: Designing and Evaluating Multimodal AI-generated Digital Twins for Strengthening Future Self-Continuity5 Dec 2025
- 2025Diffusion Models for Future Networks and Communications: A Comprehensive Survey3 Aug 2025
- 2025"X of Information'' Continuum: A Survey on AI-Driven Multi-dimensional Metrics for Next-Generation Networked Systems25 Jul 2025
- 2025Generative Diffusion Models for Wireless Networks: Fundamental, Architecture, and State-of-the-Art22 Jul 2025
- 2025Mitigating Catastrophic Forgetting with Adaptive Transformer Block Expansion in Federated Fine-Tuning6 Jun 2025
- 2025Generative Artificial Intelligence for Internet of Things Computing: A Systematic Survey10 Apr 2025
- 2024Sustainable Diffusion-based Incentive Mechanism for Generative AI-driven Digital Twins in Industrial Cyber-Physical Systems2 Aug 2024
- 2024Hybrid RAG-empowered Multi-modal LLM for Secure Data Management in Internet of Medical Things: A Diffusion-based Contract Approach1 Jul 2024