U-Net v2: Rethinking the Skip Connections of U-Net for Medical Image Segmentation
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Abstract (arXiv)
In this paper, we introduce U-Net v2, a new robust and efficient U-Net variant for medical image segmentation. It aims to augment the infusion of semantic information into low-level features while simultaneously refining high-level features with finer details. For an input image, we begin by extracting multi-level features with a deep neural network encoder. Next, we enhance the feature map of each level by infusing semantic information from higher-level features and integrating finer details from lower-level features through Hadamard product. Our novel skip connections empower features of all the levels with enriched semantic characteristics and intricate details. The improved features are subsequently transmitted to the decoder for further processing and segmentation. Our method can be seamlessly integrated into any Encoder-Decoder network. We evaluate our method on several public medical image segmentation datasets for skin lesion segmentation and polyp segmentation, and the experimental results demonstrate the segmentation accuracy of our new method over state-of-the-art methods, while preserving memory and computational efficiency. Code is available at: https://github.com/yaoppeng/U-Net_v2
Key facts. Cited by 23 papers in the map (data through 14 Oct 2026). Builds on 21 of its 25 references that are in the map. First posted on arXiv 29 Nov 2023.
Builds on
21 of 25 references.
References · 21
- 2015Deep Residual Learning for Image Recognitioncited by 52,096
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,713
- 2014Fully Convolutional Networks for Semantic Segmentationcited by 4,859
- 2016DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFscited by 3,241
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- 2021Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutionscited by 1,962
- 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,525
- 2018Path Aggregation Network for Instance Segmentationcited by 798
- 2019Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)cited by 669
9 more
- 2019Kvasir-SEG: A Segmented Polyp Datasetcited by 589
- 2020PraNet: Parallel Reverse Attention Network for Polyp Segmentationcited by 460
- 2016A Benchmark for Endoluminal Scene Segmentation of Colonoscopy Imagescited by 221
- 2021Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformerscited by 159
- 2021Shallow Attention Network for Polyp Segmentationcited by 107
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- 2018MDU-Net: Multi-scale Densely Connected U-Net for biomedical image segmentationcited by 27
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Citing papers per year: 2024: 11; 2025: 4; 2026: 8.
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- 2024VM-UNET-V2 Rethinking Vision Mamba UNet for Medical Image Segmentationcited by 39
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentationcited by 35
- 2024Rotate to Scan: UNet-like Mamba with Triplet SSM Module for Medical Image Segmentationcited by 12
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- 2025Topo-VM-UNetV2: Encoding Topology into Vision Mamba UNet for Polyp Segmentationcited by 5
- 2024SkinMamba: A Precision Skin Lesion Segmentation Architecture with Cross-Scale Global State Modeling and Frequency Boundary Guidancecited by 4
- 2025SA-UNetv2: Rethinking Spatial Attention U-Net for Retinal Vessel Segmentationcited by 1
- 2026Learning with Geometric Priors in U-Net Variants for Polyp Segmentationcited by 1
- 2026SEMIR: Semantic Minor-Induced Representation Learning on Graphs for Visual Segmentationcited by 1
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- 2024LiteNeXt: A Novel Lightweight ConvMixer-based Model with Self-embedding Representation Parallel for Medical Image Segmentationcited by 0
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- 2025Simple is what you need for efficient and accurate medical image segmentationcited by 0
- 2025When Swin Transformer Meets KANs: An Improved Transformer Architecture for Medical Image Segmentationcited by 0
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- 2026AdaKAN: A dual-branch adaptive Kolmogorov-Arnold network for medical image segmentationcited by 0
- 2026AdaKAN: A dual-branch adaptive Kolmogorov-Arnold network for medical image segmentation24 Jul 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026Patch-MoE Mamba: A Patch-Ordered Mixture-of-Experts State Space Architecture for Medical Image Segmentation18 May 2026
- 2026SEMIR: Semantic Minor-Induced Representation Learning on Graphs for Visual Segmentation12 May 2026
- 2026XAttnRes: Cross-Stage Attention Residuals for Medical Image Segmentation28 Mar 2026
- 2026SGDC: Structurally-Guided Dynamic Convolution for Medical Image Segmentation26 Feb 2026
- 2026Learning with Geometric Priors in U-Net Variants for Polyp Segmentation24 Jan 2026
- 2026IMSAHLO: Integrating Multi-Scale Attention and Hybrid Loss Optimization Framework for Robust Neuronal Brain Cell Segmentation14 Jan 2026
- 2025When Swin Transformer Meets KANs: An Improved Transformer Architecture for Medical Image Segmentation6 Nov 2025
- 2025SA-UNetv2: Rethinking Spatial Attention U-Net for Retinal Vessel Segmentation15 Sep 2025
- 2025Simple is what you need for efficient and accurate medical image segmentation16 Jun 2025
- 2025Topo-VM-UNetV2: Encoding Topology into Vision Mamba UNet for Polyp Segmentation9 May 2025
11 more
- 2024When Mamba Meets xLSTM: An Efficient and Precise Method with the xLSTM-VMUNet Model for Skin lesion Segmentation14 Nov 2024
- 2024Vascular Segmentation of Functional Ultrasound Images using Deep Learning28 Oct 2024
- 2024SkinMamba: A Precision Skin Lesion Segmentation Architecture with Cross-Scale Global State Modeling and Frequency Boundary Guidance17 Sep 2024
- 2024Cross-Organ Domain Adaptive Neural Network for Pancreatic Endoscopic Ultrasound Image Segmentation7 Sep 2024
- 2024HMT-UNet: A hybird Mamba-Transformer Vision UNet for Medical Image Segmentation21 Aug 2024
- 2024Rethinking Medical Anomaly Detection in Brain MRI: An Image Quality Assessment Perspective15 Aug 2024
- 2024LiteNeXt: A Novel Lightweight ConvMixer-based Model with Self-embedding Representation Parallel for Medical Image Segmentation4 Apr 2024
- 2024Rotate to Scan: UNet-like Mamba with Triplet SSM Module for Medical Image Segmentation26 Mar 2024
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentation20 Mar 2024
- 2024VM-UNET-V2 Rethinking Vision Mamba UNet for Medical Image Segmentation14 Mar 2024
- 2024CausalCellSegmenter: Causal Inference inspired Diversified Aggregation Convolution for Pathology Image Segmentation10 Mar 2024
- 2024VM-UNET-V2 Rethinking Vision Mamba UNet for Medical Image Segmentationcited by 39
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentationcited by 35
- 2024Rotate to Scan: UNet-like Mamba with Triplet SSM Module for Medical Image Segmentationcited by 12
- 2024HMT-UNet: A hybird Mamba-Transformer Vision UNet for Medical Image Segmentationcited by 6
- 2025Topo-VM-UNetV2: Encoding Topology into Vision Mamba UNet for Polyp Segmentationcited by 5
- 2024When Mamba Meets xLSTM: An Efficient and Precise Method with the xLSTM-VMUNet Model for Skin lesion Segmentationcited by 0
- 2025Topo-VM-UNetV2: Encoding Topology into Vision Mamba UNet for Polyp Segmentation9 May 2025
- 2024When Mamba Meets xLSTM: An Efficient and Precise Method with the xLSTM-VMUNet Model for Skin lesion Segmentation14 Nov 2024
- 2024HMT-UNet: A hybird Mamba-Transformer Vision UNet for Medical Image Segmentation21 Aug 2024
- 2024Rotate to Scan: UNet-like Mamba with Triplet SSM Module for Medical Image Segmentation26 Mar 2024
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentation20 Mar 2024
- 2024VM-UNET-V2 Rethinking Vision Mamba UNet for Medical Image Segmentation14 Mar 2024
- 2024SkinMamba: A Precision Skin Lesion Segmentation Architecture with Cross-Scale Global State Modeling and Frequency Boundary Guidancecited by 4
- 2025SA-UNetv2: Rethinking Spatial Attention U-Net for Retinal Vessel Segmentationcited by 1
- 2026Learning with Geometric Priors in U-Net Variants for Polyp Segmentationcited by 1
- 2026SEMIR: Semantic Minor-Induced Representation Learning on Graphs for Visual Segmentationcited by 1
- 2024CausalCellSegmenter: Causal Inference inspired Diversified Aggregation Convolution for Pathology Image Segmentationcited by 0
- 2024LiteNeXt: A Novel Lightweight ConvMixer-based Model with Self-embedding Representation Parallel for Medical Image Segmentationcited by 0
- 2024Rethinking Medical Anomaly Detection in Brain MRI: An Image Quality Assessment Perspectivecited by 0
- 2024Cross-Organ Domain Adaptive Neural Network for Pancreatic Endoscopic Ultrasound Image Segmentationcited by 0
- 2024Vascular Segmentation of Functional Ultrasound Images using Deep Learningcited by 0
- 2025Simple is what you need for efficient and accurate medical image segmentationcited by 0
- 2025When Swin Transformer Meets KANs: An Improved Transformer Architecture for Medical Image Segmentationcited by 0
- 2026IMSAHLO: Integrating Multi-Scale Attention and Hybrid Loss Optimization Framework for Robust Neuronal Brain Cell Segmentationcited by 0
12 most cited of 16 All 16 (JSON)
- 2026AdaKAN: A dual-branch adaptive Kolmogorov-Arnold network for medical image segmentation24 Jul 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026SEMIR: Semantic Minor-Induced Representation Learning on Graphs for Visual Segmentation12 May 2026
- 2026XAttnRes: Cross-Stage Attention Residuals for Medical Image Segmentation28 Mar 2026
- 2026SGDC: Structurally-Guided Dynamic Convolution for Medical Image Segmentation26 Feb 2026
- 2026Learning with Geometric Priors in U-Net Variants for Polyp Segmentation24 Jan 2026
- 2026IMSAHLO: Integrating Multi-Scale Attention and Hybrid Loss Optimization Framework for Robust Neuronal Brain Cell Segmentation14 Jan 2026
- 2025When Swin Transformer Meets KANs: An Improved Transformer Architecture for Medical Image Segmentation6 Nov 2025
- 2025SA-UNetv2: Rethinking Spatial Attention U-Net for Retinal Vessel Segmentation15 Sep 2025
- 2025Simple is what you need for efficient and accurate medical image segmentation16 Jun 2025
- 2024Vascular Segmentation of Functional Ultrasound Images using Deep Learning28 Oct 2024
- 2024SkinMamba: A Precision Skin Lesion Segmentation Architecture with Cross-Scale Global State Modeling and Frequency Boundary Guidance17 Sep 2024
12 newest of 16 All 16 (JSON)