Truncated proposals for scalable and hassle-free simulation-based inference
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Abstract (arXiv)
Simulation-based inference (SBI) solves statistical inverse problems by repeatedly running a stochastic simulator and inferring posterior distributions from model-simulations. To improve simulation efficiency, several inference methods take a sequential approach and iteratively adapt the proposal distributions from which model simulations are generated. However, many of these sequential methods are difficult to use in practice, both because the resulting optimisation problems can be challenging and efficient diagnostic tools are lacking. To overcome these issues, we present Truncated Sequential Neural Posterior Estimation (TSNPE). TSNPE performs sequential inference with truncated proposals, sidestepping the optimisation issues of alternative approaches. In addition, TSNPE allows to efficiently perform coverage tests that can scale to complex models with many parameters. We demonstrate that TSNPE performs on par with previous methods on established benchmark tasks. We then apply TSNPE to two challenging problems from neuroscience and show that TSNPE can successfully obtain the posterior distributions, whereas previous methods fail. Overall, our results demonstrate that TSNPE is an efficient, accurate, and robust inference method that can scale to challenging scientific models.
Key facts. Cited by 40 papers in the map (data through 7 Oct 2026). Builds on 22 of its 67 references that are in the map. First posted on arXiv 10 Oct 2022.
Builds on
22 of 67 references.
References · 22
- 2019PyTorch: An Imperative Style, High-Performance Deep Learning Librarycited by 20,160
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- 2018Sequential Neural Likelihood: Fast Likelihood-free Inference with Autoregressive Flowscited by 217
- 2019Automatic Posterior Transformation for Likelihood-Free Inferencecited by 216
- 2017Flexible statistical inference for mechanistic models of neural dynamicscited by 162
- 2021Benchmarking Simulation-Based Inferencecited by 160
- 2020BayesFlow: Learning complex stochastic models with invertible neural networkscited by 139
- 2018Validating Bayesian Inference Algorithms with Simulation-Based Calibrationcited by 118
- 2020On Contrastive Learning for Likelihood-free Inferencecited by 96
- 2016Likelihood-free inference by ratio estimationcited by 80
- 2021Real-time gravitational-wave science with neural posterior estimationcited by 76
- 2018Likelihood-free inference with emulator networkscited by 61
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- 2022GATSBI: Generative Adversarial Training for Simulation-Based Inferencecited by 36
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- 2019Conditional Density Estimation Tools in Python and R with Applications to Photometric Redshifts and Likelihood-Free Cosmological Inferencecited by 21
- 2016Inference Networks for Sequential Monte Carlo in Graphical Modelscited by 19
- 2017Efficient acquisition rules for model-based approximate Bayesian computationcited by 16
- 2021Group equivariant neural posterior estimationcited by 16
- 2013Diagnostic tools of approximate Bayesian computation using the coverage propertycited by 10
- 2020Simulation-efficient marginal posterior estimation with swyft: stop wasting your precious timecited by 7
- 2016BluePyOpt: Leveraging open source software and cloud infrastructure to optimise model parameters in neurosciencecited by 4
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Citing papers per year: 2022: 1; 2023: 10; 2024: 11; 2025: 10; 2026: 8.
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- 2024All-in-one simulation-based inferencecited by 71
- 2023Sampling-Based Accuracy Testing of Posterior Estimators for General Inferencecited by 45
- 2023JANA: Jointly Amortized Neural Approximation of Complex Bayesian Modelscited by 41
- 2025Simulation-Based Inference: A Practical Guidecited by 30
- 2024sbi reloaded: a toolkit for simulation-based inference workflowscited by 23
- 2023Consistency Models for Scalable and Fast Simulation-Based Inferencecited by 22
- 2024Real-time gravitational-wave inference for binary neutron stars using machine learningcited by 21
- 2023Adversarial robustness of amortized Bayesian inferencecited by 17
- 2023Generalized Bayesian Inference for Scientific Simulators via Amortized Cost Estimationcited by 17
- 2025Effortless, Simulation-Efficient Bayesian Inference using Tabular Foundation Modelscited by 13
- 2025Multifidelity Simulation-based Inference for Computationally Expensive Simulatorscited by 9
- 2025Simulation-based Bayesian inference under model misspecificationcited by 9
28 more
- 2023Simulation-based Inference for High-dimensional Data using Surjective Sequential Neural Likelihood Estimationcited by 8
- 2024Compositional simulation-based inference for time seriescited by 8
- 2023InVAErt networks: a data-driven framework for model synthesis and identifiability analysiscited by 6
- 2024Preconditioned Neural Posterior Estimation for Likelihood-free Inferencecited by 6
- 2024Conditional diffusions for amortized neural posterior estimationcited by 6
- 2023Variational Inference with Coverage Guarantees in Simulation-Based Inferencecited by 5
- 2024A Kernel-Based Conditional Two-Sample Test Using Nearest Neighbors (with Applications to Calibration, Regression Curves, and Simulation-Based Inference)cited by 5
- 2024A Comprehensive Guide to Simulation-based Inference in Computational Biologycited by 5
- 2025CP4SBI: Local Conformal Calibration of Credible Sets in Simulation-Based Inferencecited by 5
- 2024Fast and Reliable Probabilistic Reflectometry Inversion with Prior-Amortized Neural Posterior Estimationcited by 4
- 2024Demonstrating the power and flexibility of variational assumptions for amortized neural posterior estimation in environmental applicationscited by 3
- 2022Bayesian score calibration for approximate modelscited by 2
- 2023Amortized Bayesian Decision Making for simulation-based modelscited by 1
- 2025Fine Tuning a Simulation-Driven Estimatorcited by 1
- 2025Uncertainty-Aware Surrogate-based Amortized Bayesian Inference for Computationally Expensive Modelscited by 1
- 2025Causal Posterior Estimationcited by 1
- 2026Supercharging Simulation-Based Inference for Bayesian Optimal Experimental Designcited by 1
- 2026An Introduction to Bayesian and Frequentist Simulation-Based Inference with Machine Learningcited by 1
- 2023An efficient likelihood-free Bayesian inference method based on sequential neural posterior estimationcited by 0
- 2024Leveraging Nested MLMC for Sequential Neural Posterior Estimation with Intractable Likelihoodscited by 0
- 2025Neural Posterior Estimation on Exponential Random Graph Models: Evaluating Bias and Implementation Challengescited by 0
- 2025Recent Advances in Simulation-based Inference for Gravitational Wave Data Analysiscited by 0
- 2026Tokenised Flow Matching for Hierarchical Simulation Based Inferencecited by 0
- 2026Mixed neural posterior estimation for simulators with discrete and continuous parameterscited by 0
- 2026A Convex Approximation Framework for Neural Likelihood-Based Bayesian Inverse Problemscited by 0
- 2026Program Synthesis for Simulation-Based Inference: Joint Model Selection and Parameter Estimationcited by 0
- 2026Calibrating subgrid parametrizations of single-column ocean models via simulation-based inferencecited by 0
- 2026A Three-Way Testing Framework for Quantifying Epistemic Calibration Uncertainty in SBIcited by 0
- 2026A Three-Way Testing Framework for Quantifying Epistemic Calibration Uncertainty in SBI21 Sep 2026
- 2026Calibrating subgrid parametrizations of single-column ocean models via simulation-based inference3 Sep 2026
- 2026An Introduction to Bayesian and Frequentist Simulation-Based Inference with Machine Learning23 Jul 2026
- 2026Program Synthesis for Simulation-Based Inference: Joint Model Selection and Parameter Estimation20 Jul 2026
- 2026A Convex Approximation Framework for Neural Likelihood-Based Bayesian Inverse Problems7 Jul 2026
- 2026Mixed neural posterior estimation for simulators with discrete and continuous parameters13 May 2026
- 2026Tokenised Flow Matching for Hierarchical Simulation Based Inference22 Apr 2026
- 2026Supercharging Simulation-Based Inference for Bayesian Optimal Experimental Design6 Feb 2026
- 2025CP4SBI: Local Conformal Calibration of Credible Sets in Simulation-Based Inference23 Aug 2025
- 2025Simulation-Based Inference: A Practical Guide18 Aug 2025
- 2025Recent Advances in Simulation-based Inference for Gravitational Wave Data Analysis15 Jul 2025
- 2025Causal Posterior Estimation27 May 2025
28 more
- 2025Uncertainty-Aware Surrogate-based Amortized Bayesian Inference for Computationally Expensive Models13 May 2025
- 2025Effortless, Simulation-Efficient Bayesian Inference using Tabular Foundation Models24 Apr 2025
- 2025Neural Posterior Estimation on Exponential Random Graph Models: Evaluating Bias and Implementation Challenges12 Apr 2025
- 2025Fine Tuning a Simulation-Driven Estimator6 Apr 2025
- 2025Simulation-based Bayesian inference under model misspecification16 Mar 2025
- 2025Multifidelity Simulation-based Inference for Computationally Expensive Simulators12 Feb 2025
- 2024sbi reloaded: a toolkit for simulation-based inference workflows26 Nov 2024
- 2024Compositional simulation-based inference for time series5 Nov 2024
- 2024Conditional diffusions for amortized neural posterior estimation24 Oct 2024
- 2024A Comprehensive Guide to Simulation-based Inference in Computational Biology29 Sep 2024
- 2024Fast and Reliable Probabilistic Reflectometry Inversion with Prior-Amortized Neural Posterior Estimation26 Jul 2024
- 2024A Kernel-Based Conditional Two-Sample Test Using Nearest Neighbors (with Applications to Calibration, Regression Curves, and Simulation-Based Inference)23 Jul 2024
- 2024Real-time gravitational-wave inference for binary neutron stars using machine learning12 Jul 2024
- 2024Preconditioned Neural Posterior Estimation for Likelihood-free Inference21 Apr 2024
- 2024Demonstrating the power and flexibility of variational assumptions for amortized neural posterior estimation in environmental applications16 Apr 2024
- 2024All-in-one simulation-based inference15 Apr 2024
- 2024Leveraging Nested MLMC for Sequential Neural Posterior Estimation with Intractable Likelihoods30 Jan 2024
- 2023Consistency Models for Scalable and Fast Simulation-Based Inference9 Dec 2023
- 2023Amortized Bayesian Decision Making for simulation-based models5 Dec 2023
- 2023An efficient likelihood-free Bayesian inference method based on sequential neural posterior estimation21 Nov 2023
- 2023Simulation-based Inference for High-dimensional Data using Surjective Sequential Neural Likelihood Estimation2 Aug 2023
- 2023InVAErt networks: a data-driven framework for model synthesis and identifiability analysis24 Jul 2023
- 2023Generalized Bayesian Inference for Scientific Simulators via Amortized Cost Estimation24 May 2023
- 2023Adversarial robustness of amortized Bayesian inference24 May 2023
- 2023Variational Inference with Coverage Guarantees in Simulation-Based Inference23 May 2023
- 2023JANA: Jointly Amortized Neural Approximation of Complex Bayesian Models17 Feb 2023
- 2023Sampling-Based Accuracy Testing of Posterior Estimators for General Inference6 Feb 2023
- 2022Bayesian score calibration for approximate models10 Nov 2022
- 2024All-in-one simulation-based inferencecited by 71
- 2023Sampling-Based Accuracy Testing of Posterior Estimators for General Inferencecited by 45
- 2023JANA: Jointly Amortized Neural Approximation of Complex Bayesian Modelscited by 41
- 2025Simulation-Based Inference: A Practical Guidecited by 30
- 2024sbi reloaded: a toolkit for simulation-based inference workflowscited by 23
- 2024Real-time gravitational-wave inference for binary neutron stars using machine learningcited by 21
- 2023Adversarial robustness of amortized Bayesian inferencecited by 17
- 2023Generalized Bayesian Inference for Scientific Simulators via Amortized Cost Estimationcited by 17
- 2025Effortless, Simulation-Efficient Bayesian Inference using Tabular Foundation Modelscited by 13
- 2025Multifidelity Simulation-based Inference for Computationally Expensive Simulatorscited by 9
- 2025Simulation-based Bayesian inference under model misspecificationcited by 9
- 2023Simulation-based Inference for High-dimensional Data using Surjective Sequential Neural Likelihood Estimationcited by 8
12 most cited of 38 All 38 (JSON)
- 2026A Three-Way Testing Framework for Quantifying Epistemic Calibration Uncertainty in SBI21 Sep 2026
- 2026Calibrating subgrid parametrizations of single-column ocean models via simulation-based inference3 Sep 2026
- 2026An Introduction to Bayesian and Frequentist Simulation-Based Inference with Machine Learning23 Jul 2026
- 2026Program Synthesis for Simulation-Based Inference: Joint Model Selection and Parameter Estimation20 Jul 2026
- 2026A Convex Approximation Framework for Neural Likelihood-Based Bayesian Inverse Problems7 Jul 2026
- 2026Mixed neural posterior estimation for simulators with discrete and continuous parameters13 May 2026
- 2026Supercharging Simulation-Based Inference for Bayesian Optimal Experimental Design6 Feb 2026
- 2025CP4SBI: Local Conformal Calibration of Credible Sets in Simulation-Based Inference23 Aug 2025
- 2025Simulation-Based Inference: A Practical Guide18 Aug 2025
- 2025Recent Advances in Simulation-based Inference for Gravitational Wave Data Analysis15 Jul 2025
- 2025Causal Posterior Estimation27 May 2025
- 2025Uncertainty-Aware Surrogate-based Amortized Bayesian Inference for Computationally Expensive Models13 May 2025
12 newest of 38 All 38 (JSON)