Collaborative Graph Learning with Auxiliary Text for Temporal Event Prediction in Healthcare
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Abstract (arXiv)
Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these predictions. However, many deep learning based methods are not satisfactory in solving several key challenges: 1) effectively utilizing disease domain knowledge; 2) collaboratively learning representations of patients and diseases; and 3) incorporating unstructured text. To address these issues, we propose a collaborative graph learning model to explore patient-disease interactions and medical domain knowledge. Our solution is able to capture structural features of both patients and diseases. The proposed model also utilizes unstructured text data by employing an attention regulation strategy and then integrates attentive text features into a sequential learning process. We conduct extensive experiments on two important healthcare problems to show the competitive prediction performance of the proposed method compared with various state-of-the-art models. We also confirm the effectiveness of learned representations and model interpretability by a set of ablation and case studies.
Key facts. Cited by 30 papers in the map (data through 14 Oct 2026). Builds on 15 of its 23 references that are in the map. First posted on arXiv 16 May 2021.
Builds on
15 of 23 references.
References · 15
- 2015Effective Approaches to Attention-based Neural Machine Translationcited by 1,026
- 2019Attention is not Explanationcited by 929
- 2019Is Attention Interpretable?cited by 389
- 2016RETAIN: An Interpretable Predictive Model for Healthcare using Reverse Time Attention Mechanismcited by 349
- 2015Doctor AI: Predicting Clinical Events via Recurrent Neural Networkscited by 208
- 2016GRAM: Graph-based Attention Model for Healthcare Representation Learningcited by 156
- 2019Pre-training of Graph Augmented Transformers for Medication Recommendationcited by 127
- 2017Dipole: Diagnosis Prediction in Healthcare via Attention-based Bidirectional Recurrent Neural Networkscited by 116
- 2019Learning to Deceive with Attention-Based Explanationscited by 111
- 2019Learning the Graphical Structure of Electronic Health Records with Graph Convolutional Transformercited by 88
- 2018MiME: Multilevel Medical Embedding of Electronic Health Records for Predictive Healthcarecited by 72
- 2016Deepr: A Convolutional Net for Medical Recordscited by 60
3 more
- 2019ConCare: Personalized Clinical Feature Embedding via Capturing the Healthcare Contextcited by 56
- 2019AdaCare: Explainable Clinical Health Status Representation Learning via Scale-Adaptive Feature Extraction and Recalibrationcited by 51
- 2017SMR: Medical Knowledge Graph Embedding for Safe Medicine Recommendationcited by 15
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Citing papers per year: 2021: 2; 2022: 2; 2023: 5; 2024: 11; 2025: 8; 2026: 2.
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- 2023GraphCare: Enhancing Healthcare Predictions with Personalized Knowledge Graphscited by 58
- 2024REALM: RAG-Driven Enhancement of Multimodal Electronic Health Records Analysis via Large Language Modelscited by 23
- 2024RAM-EHR: Retrieval Augmentation Meets Clinical Predictions on Electronic Health Recordscited by 21
- 2021Context-aware Health Event Prediction via Transition Functions on Dynamic Disease Graphscited by 20
- 2024EMERGE: Enhancing Multimodal Electronic Health Records Predictive Modeling with Retrieval-Augmented Generationcited by 17
- 2022Multi-Label Clinical Time-Series Generation via Conditional GANcited by 16
- 2021Self-Supervised Graph Learning with Hyperbolic Embedding for Temporal Health Event Predictioncited by 15
- 2024Predictive Modeling with Temporal Graphical Representation on Electronic Health Recordscited by 9
- 2024SMART: Towards Pre-trained Missing-Aware Model for Patient Health Status Predictioncited by 8
- 2025Memorize and Rank: Elevating Large Language Models for Clinical Diagnosis Predictioncited by 8
- 2024Next Visit Diagnosis Prediction via Medical Code-Centric Multimodal Contrastive EHR Modelling with Hierarchical Regularisationcited by 5
- 2025No Black Boxes: Interpretable and Interactable Predictive Healthcare with Knowledge-Enhanced Agentic Causal Discoverycited by 5
18 more
- 2023Towards Semi-Structured Automatic ICD Coding via Tree-based Contrastive Learningcited by 4
- 2024SepsisCalc: Integrating Clinical Calculators into Early Sepsis Prediction via Dynamic Temporal Graph Constructioncited by 4
- 2025Multi-Ontology Integration with Dual-Axis Propagation for Medical Concept Representationcited by 4
- 2024Bridging Stepwise Lab-Informed Pretraining and Knowledge-Guided Learning for Diagnostic Reasoningcited by 3
- 2025Self-Explaining Hypergraph Neural Networks for Diagnosis Predictioncited by 3
- 2025Discovering Hierarchy-Grounded Domains with Adaptive Granularity for Clinical Domain Generalizationcited by 3
- 2023A Survey on Event Prediction Methods from a Systems Perspective: Bringing Together Disparate Research Areascited by 2
- 2023Multi-modal Graph Learning over UMLS Knowledge Graphscited by 2
- 2024Time-aware Heterogeneous Graph Transformer with Adaptive Attention Merging for Health Event Predictioncited by 1
- 2024MPLite: Multi-Aspect Pretraining for Mining Clinical Health Recordscited by 1
- 2025CURENet: Combining Unified Representations for Efficient Chronic Disease Predictioncited by 1
- 2026Text-Attributed Knowledge Graph Enrichment with Large Language Models for Medical Concept Representationcited by 1
- 2022MedFACT: Modeling Medical Feature Correlations in Patient Health Representation Learning via Feature Clusteringcited by 0
- 2023Adaptive Taxonomy Learning and Historical Patterns Modelling for Patent Classificationcited by 0
- 2024IntelliCare: Improving Healthcare Analysis with Variance-Controlled Patient-Level Knowledge from Large Language Modelscited by 0
- 2025THCM-CAL: Temporal-Hierarchical Causal Modelling with Conformal Calibration for Clinical Risk Predictioncited by 0
- 2025Structure-aware Hypergraph Transformer for Diagnosis Prediction in Electronic Health Recordscited by 0
- 2026REFINE: LLM Refinement over Budgeted Text-Attributed Graphs for Personalized Medical Concept Representationcited by 0
- 2026REFINE: LLM Refinement over Budgeted Text-Attributed Graphs for Personalized Medical Concept Representation3 Sep 2026
- 2026Text-Attributed Knowledge Graph Enrichment with Large Language Models for Medical Concept Representation14 Apr 2026
- 2025CURENet: Combining Unified Representations for Efficient Chronic Disease Prediction14 Nov 2025
- 2025Multi-Ontology Integration with Dual-Axis Propagation for Medical Concept Representation29 Aug 2025
- 2025Structure-aware Hypergraph Transformer for Diagnosis Prediction in Electronic Health Records28 Aug 2025
- 2025THCM-CAL: Temporal-Hierarchical Causal Modelling with Conformal Calibration for Clinical Risk Prediction21 Jun 2025
- 2025Discovering Hierarchy-Grounded Domains with Adaptive Granularity for Clinical Domain Generalization8 Jun 2025
- 2025No Black Boxes: Interpretable and Interactable Predictive Healthcare with Knowledge-Enhanced Agentic Causal Discovery22 May 2025
- 2025Self-Explaining Hypergraph Neural Networks for Diagnosis Prediction15 Feb 2025
- 2025Memorize and Rank: Elevating Large Language Models for Clinical Diagnosis Prediction28 Jan 2025
- 2024SepsisCalc: Integrating Clinical Calculators into Early Sepsis Prediction via Dynamic Temporal Graph Construction31 Dec 2024
- 2024MPLite: Multi-Aspect Pretraining for Mining Clinical Health Records17 Nov 2024
18 more
- 2024Bridging Stepwise Lab-Informed Pretraining and Knowledge-Guided Learning for Diagnostic Reasoning25 Oct 2024
- 2024IntelliCare: Improving Healthcare Analysis with Variance-Controlled Patient-Level Knowledge from Large Language Models23 Aug 2024
- 2024EMERGE: Enhancing Multimodal Electronic Health Records Predictive Modeling with Retrieval-Augmented Generation27 May 2024
- 2024SMART: Towards Pre-trained Missing-Aware Model for Patient Health Status Prediction15 May 2024
- 2024Predictive Modeling with Temporal Graphical Representation on Electronic Health Records7 May 2024
- 2024Time-aware Heterogeneous Graph Transformer with Adaptive Attention Merging for Health Event Prediction23 Apr 2024
- 2024RAM-EHR: Retrieval Augmentation Meets Clinical Predictions on Electronic Health Records25 Feb 2024
- 2024REALM: RAG-Driven Enhancement of Multimodal Electronic Health Records Analysis via Large Language Models10 Feb 2024
- 2024Next Visit Diagnosis Prediction via Medical Code-Centric Multimodal Contrastive EHR Modelling with Hierarchical Regularisation22 Jan 2024
- 2023Towards Semi-Structured Automatic ICD Coding via Tree-based Contrastive Learning14 Oct 2023
- 2023Adaptive Taxonomy Learning and Historical Patterns Modelling for Patent Classification10 Aug 2023
- 2023Multi-modal Graph Learning over UMLS Knowledge Graphs10 Jul 2023
- 2023GraphCare: Enhancing Healthcare Predictions with Personalized Knowledge Graphs22 May 2023
- 2023A Survey on Event Prediction Methods from a Systems Perspective: Bringing Together Disparate Research Areas8 Feb 2023
- 2022MedFACT: Modeling Medical Feature Correlations in Patient Health Representation Learning via Feature Clustering21 Apr 2022
- 2022Multi-Label Clinical Time-Series Generation via Conditional GAN10 Apr 2022
- 2021Context-aware Health Event Prediction via Transition Functions on Dynamic Disease Graphs9 Dec 2021
- 2021Self-Supervised Graph Learning with Hyperbolic Embedding for Temporal Health Event Prediction9 Jun 2021
- 2023GraphCare: Enhancing Healthcare Predictions with Personalized Knowledge Graphscited by 58
- 2024REALM: RAG-Driven Enhancement of Multimodal Electronic Health Records Analysis via Large Language Modelscited by 23
- 2024RAM-EHR: Retrieval Augmentation Meets Clinical Predictions on Electronic Health Recordscited by 21
- 2021Context-aware Health Event Prediction via Transition Functions on Dynamic Disease Graphscited by 20
- 2022Multi-Label Clinical Time-Series Generation via Conditional GANcited by 16
- 2021Self-Supervised Graph Learning with Hyperbolic Embedding for Temporal Health Event Predictioncited by 15
- 2024Predictive Modeling with Temporal Graphical Representation on Electronic Health Recordscited by 9
- 2024SMART: Towards Pre-trained Missing-Aware Model for Patient Health Status Predictioncited by 8
- 2025Memorize and Rank: Elevating Large Language Models for Clinical Diagnosis Predictioncited by 8
- 2024Next Visit Diagnosis Prediction via Medical Code-Centric Multimodal Contrastive EHR Modelling with Hierarchical Regularisationcited by 5
- 2023Towards Semi-Structured Automatic ICD Coding via Tree-based Contrastive Learningcited by 4
- 2024SepsisCalc: Integrating Clinical Calculators into Early Sepsis Prediction via Dynamic Temporal Graph Constructioncited by 4
12 most cited of 27 All 27 (JSON)
- 2026REFINE: LLM Refinement over Budgeted Text-Attributed Graphs for Personalized Medical Concept Representation3 Sep 2026
- 2026Text-Attributed Knowledge Graph Enrichment with Large Language Models for Medical Concept Representation14 Apr 2026
- 2025CURENet: Combining Unified Representations for Efficient Chronic Disease Prediction14 Nov 2025
- 2025Multi-Ontology Integration with Dual-Axis Propagation for Medical Concept Representation29 Aug 2025
- 2025Structure-aware Hypergraph Transformer for Diagnosis Prediction in Electronic Health Records28 Aug 2025
- 2025THCM-CAL: Temporal-Hierarchical Causal Modelling with Conformal Calibration for Clinical Risk Prediction21 Jun 2025
- 2025Discovering Hierarchy-Grounded Domains with Adaptive Granularity for Clinical Domain Generalization8 Jun 2025
- 2025Self-Explaining Hypergraph Neural Networks for Diagnosis Prediction15 Feb 2025
- 2025Memorize and Rank: Elevating Large Language Models for Clinical Diagnosis Prediction28 Jan 2025
- 2024SepsisCalc: Integrating Clinical Calculators into Early Sepsis Prediction via Dynamic Temporal Graph Construction31 Dec 2024
- 2024MPLite: Multi-Aspect Pretraining for Mining Clinical Health Records17 Nov 2024
- 2024IntelliCare: Improving Healthcare Analysis with Variance-Controlled Patient-Level Knowledge from Large Language Models23 Aug 2024
12 newest of 27 All 27 (JSON)