Self-Supervision with Superpixels: Training Few-shot Medical Image Segmentation without Annotation
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Abstract (arXiv)
Few-shot semantic segmentation (FSS) has great potential for medical imaging applications. Most of the existing FSS techniques require abundant annotated semantic classes for training. However, these methods may not be applicable for medical images due to the lack of annotations. To address this problem we make several contributions: (1) A novel self-supervised FSS framework for medical images in order to eliminate the requirement for annotations during training. Additionally, superpixel-based pseudo-labels are generated to provide supervision; (2) An adaptive local prototype pooling module plugged into prototypical networks, to solve the common challenging foreground-background imbalance problem in medical image segmentation; (3) We demonstrate the general applicability of the proposed approach for medical images using three different tasks: abdominal organ segmentation for CT and MRI, as well as cardiac segmentation for MRI. Our results show that, for medical image segmentation, the proposed method outperforms conventional FSS methods which require manual annotations for training.
Key facts. Cited by 128 papers in the map (data through 7 Oct 2026). First posted on arXiv 20 Jul 2020.
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Citing papers per year: 2021: 25; 2022: 24; 2023: 24; 2024: 28; 2025: 14; 2026: 13.
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- 2024Medical SAM 2: Segment medical images as video via Segment Anything Model 2cited by 151
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- 2022Anomaly Detection-Inspired Few-Shot Medical Image Segmentation Through Self-Supervision With Supervoxelscited by 42
38 more
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- 2021Squeezing Backbone Feature Distributions to the Max for Efficient Few-Shot Learningcited by 14
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- 2025MAUP: Training-free Multi-center Adaptive Uncertainty-aware Prompting for Cross-domain Few-shot Medical Image Segmentationcited by 8
50 most cited of 128 All 128 (JSON)
- 2026FSS-UBrain: Multi-region Few-Shot Brain Tumor MRI Segmentation26 Sep 2026
- 2026PANDA - Prototype-Anchored Alignment for Partially Unpaired Multimodal Learning, with Applications to Alzheimers MRI and TCGA Pathology26 Aug 2026
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- 2025AGENet: Adaptive Edge-aware Geodesic Distance Learning for Few-Shot Medical Image Segmentation11 Nov 2025
- 2025DPL: Spatial-Conditioned Diffusion Prototype Enhancement for One-Shot Medical Segmentation14 Oct 2025
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- 2025Tied Prototype Model for Few-Shot Medical Image Segmentation27 Jun 2025
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- 2025Rethinking Few-Shot Medical Image Segmentation by SAM2: A Training-Free Framework with Augmentative Prompting and Dynamic Matching5 Mar 2025
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- 2024SP 3 : Superpixel-propagated pseudo-label learning for weakly semi-supervised medical image segmentation18 Nov 2024
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- 2024Few-Shot Histopathology Image Classification: Evaluating State-of-the-Art Methods and Unveiling Performance Insights25 Aug 2024
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- 2024Self-supervised Learning via Cluster Distance Prediction for Operating Room Context Awareness7 Jul 2024
- 2024Few-Shot Medical Image Segmentation with High-Fidelity Prototypes26 Jun 2024
- 2024FIESTA: Fourier-Based Semantic Augmentation with Uncertainty Guidance for Enhanced Domain Generalizability in Medical Image Segmentation20 Jun 2024
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- 2024Support-Query Prototype Fusion Network for Few-shot Medical Image Segmentation13 May 2024
50 newest of 128 All 128 (JSON)
- 2022Unsupervised Visual Defect Detection with Score-Based Generative Modelcited by 7
- 2025Semi-Supervised Biomedical Image Segmentation via Diffusion Models and Teacher-Student Co-Trainingcited by 0
- 2025Task-oriented Learnable Diffusion Timesteps for Universal Few-shot Learning of Dense Taskscited by 0
- 2026SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentationcited by 0
- 2026SD-FSMIS: Adapting Stable Diffusion for Few-Shot Medical Image Segmentation3 Apr 2026
- 2025Task-oriented Learnable Diffusion Timesteps for Universal Few-shot Learning of Dense Tasks29 Dec 2025
- 2025Semi-Supervised Biomedical Image Segmentation via Diffusion Models and Teacher-Student Co-Training2 Apr 2025
- 2022Unsupervised Visual Defect Detection with Score-Based Generative Model29 Nov 2022
- 2024Medical SAM 2: Segment medical images as video via Segment Anything Model 2cited by 151
- 2021Causality-inspired Single-source Domain Generalization for Medical Image Segmentationcited by 118
- 2022Self-Support Few-Shot Semantic Segmentationcited by 96
- 2023UniverSeg: Universal Medical Image Segmentationcited by 90
- 2021Mining Latent Classes for Few-shot Segmentationcited by 69
- 2021Recurrent Mask Refinement for Few-Shot Medical Image Segmentationcited by 63
- 2021Learning Meta-class Memory for Few-Shot Semantic Segmentationcited by 56
- 2024A Comprehensive Survey of Foundation Models in Medicinecited by 56
- 2023Domain Generalization for Medical Image Analysis: A Reviewcited by 47
- 2022Rethinking Data Augmentation for Single-source Domain Generalization in Medical Image Segmentationcited by 44
- 2021Local contrastive loss with pseudo-label based self-training for semi-supervised medical image segmentationcited by 43
- 2022Anomaly Detection-Inspired Few-Shot Medical Image Segmentation Through Self-Supervision With Supervoxelscited by 42
12 most cited of 123 All 123 (JSON)
- 2026FSS-UBrain: Multi-region Few-Shot Brain Tumor MRI Segmentation26 Sep 2026
- 2026PANDA - Prototype-Anchored Alignment for Partially Unpaired Multimodal Learning, with Applications to Alzheimers MRI and TCGA Pathology26 Aug 2026
- 2026ESRVS: Extreme Semi-Supervised Retinal Vessel Segmentation with a Single Annotated Image27 Jul 2026
- 2026ASTRA-Net: Anatomy-Specific Transfer and Representation Alignment for Drug-Induced Sleep Endoscopy Segmentation23 Jul 2026
- 2026Memory-Supported Synergistic Adaptation for Training-Free Test-Time Medical Image Segmentation20 Jul 2026
- 2026Disentangling Sampling from Training Budget in Class-Imbalanced CT Body Composition Segmentation19 May 2026
- 2026Beyond Euclidean Prototypes: Spectral Disentanglement and Geodesic Matching for Few-Shot Medical Image Segmentation18 May 2026
- 2026Geometry-aware Prototype Learning for Cross-domain Few-shot Medical Image Segmentation11 May 2026
- 2026DINO-MVR: Multi-View Readout of Frozen DINOv3 for Annotation-Efficient Medical Segmentation8 May 2026
- 2026DyABD: The Abdominal Muscle Segmentation in Dynamic MRI Benchmark25 Apr 2026
- 2026Focus on Background: Exploring SAM's Potential in Few-shot Medical Image Segmentation with Background-centric Prompting22 Mar 2026
- 2026VesselBridge3D: A Foundation Model Adaptation Framework for Label-Efficient 3D Vessel Segmentation27 Feb 2026
12 newest of 123 All 123 (JSON)