Bounding boxes for weakly supervised segmentation: Global constraints get close to full supervision
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Abstract (arXiv)
We propose a novel weakly supervised learning segmentation based on several global constraints derived from box annotations. Particularly, we leverage a classical tightness prior to a deep learning setting via imposing a set of constraints on the network outputs. Such a powerful topological prior prevents solutions from excessive shrinking by enforcing any horizontal or vertical line within the bounding box to contain, at least, one pixel of the foreground region. Furthermore, we integrate our deep tightness prior with a global background emptiness constraint, guiding training with information outside the bounding box. We demonstrate experimentally that such a global constraint is much more powerful than standard cross-entropy for the background class. Our optimization problem is challenging as it takes the form of a large set of inequality constraints on the outputs of deep networks. We solve it with sequence of unconstrained losses based on a recent powerful extension of the log-barrier method, which is well-known in the context of interior-point methods. This accommodates standard stochastic gradient descent (SGD) for training deep networks, while avoiding computationally expensive and unstable Lagrangian dual steps and projections. Extensive experiments over two different public data sets and applications (prostate and brain lesions) demonstrate that the synergy between our global tightness and emptiness priors yield very competitive performances, approaching full supervision and outperforming significantly DeepCut. Furthermore, our approach removes the need for computationally expensive proposal generation. Our code is shared anonymously.
Key facts. Cited by 40 papers in the map (data through 7 Oct 2026). First posted on arXiv 14 Apr 2020.
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Citing papers per year: 2021: 16; 2022: 8; 2023: 9; 2024: 4; 2025: 3.
40 papers.
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- 2021Source-Free Domain Adaptation for Image Segmentationcited by 45
- 2021Every Annotation Counts: Multi-label Deep Supervision for Medical Image Segmentationcited by 37
- 2021Semantic Segmentation In-the-Wild Without Seeing Any Segmentation Examplescited by 24
- 2022FedMix: Mixed Supervised Federated Learning for Medical Image Segmentationcited by 22
- 2021Medical Image Segmentation with Limited Supervision: A Review of Deep Network Modelscited by 21
- 2021Inter Extreme Points Geodesics for End-to-End Weakly Supervised Image Segmentationcited by 21
- 2021Bounding Box Tightness Prior for Weakly Supervised Image Segmentationcited by 19
- 2021Weakly supervised segmentation with cross-modality equivariant constraintscited by 18
- 2022PA-Seg: Learning from Point Annotations for 3D Medical Image Segmentation using Contextual Regularization and Cross Knowledge Distillationcited by 16
- 2025Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentationcited by 16
- 2021The surprising impact of mask-head architecture on novel class segmentationcited by 13
- 2023Versatile Medical Image Segmentation Learned from Multi-Source Datasets via Model Self-Disambiguationcited by 12
28 more
- 2022Greybox XAI: a Neural-Symbolic learning framework to produce interpretable predictions for image classificationcited by 11
- 2023Weakly-Supervised 3D Medical Image Segmentation using Geometric Prior and Contrastive Similaritycited by 9
- 2022Negative Evidence Matters in Interpretable Histology Image Classificationcited by 8
- 2021Segmentation with mixed supervision: Confidence maximization helps knowledge distillationcited by 6
- 2023Weakly Supervised Intracranial Hemorrhage Segmentation using Head-Wise Gradient-Infused Self-Attention Maps from a Swin Transformer in Categorical Learningcited by 6
- 2023Industrial Anomaly Detection and Localization Using Weakly-Supervised Residual Transformerscited by 6
- 2024FedLPPA: Learning Personalized Prompt and Aggregation for Federated Weakly-supervised Medical Image Segmentationcited by 6
- 2024LNQ 2023 challenge: Benchmark of weakly-supervised techniques for mediastinal lymph node quantificationcited by 6
- 2024Automating MedSAM by Learning Prompts with Weak Few-Shot Supervisioncited by 5
- 2021Self-supervised Multi-scale Consistency for Weakly Supervised Segmentation Learningcited by 4
- 2022A comprehensive survey on recent deep learning-based methods applied to surgical datacited by 3
- 2023Weakly Supervised Image Segmentation Beyond Tight Bounding Box Annotationscited by 3
- 2021Weakly Supervised Volumetric Segmentation via Self-taught Shape Denoising Modelcited by 2
- 2021CDRNet: Accurate Cup-to-Disc Ratio Measurement with Tight Bounding Box Supervision in Fundus Photography Using Deep Learningcited by 2
- 2023Leveraging point annotations in segmentation learning with boundary losscited by 2
- 2025Prompt learning with bounding box constraints for medical image segmentationcited by 2
- 2021Robust Trust Region for Weakly Supervised Segmentationcited by 1
- 2021Medical image segmentation with imperfect 3D bounding boxescited by 1
- 2021One-shot Weakly-Supervised Segmentation in Medical Imagescited by 1
- 2022Polar Transformation Based Multiple Instance Learning Assisting Weakly Supervised Image Segmentation With Loose Bounding Box Annotationscited by 1
- 2022Cardiac Adipose Tissue Segmentation via Image-Level Annotationscited by 1
- 2023BoxCell: Leveraging SAM for Cell Segmentation with Box Supervisioncited by 1
- 2024EP-SAM: Weakly Supervised Histopathology Segmentation via Enhanced Prompt with Segment Anythingcited by 1
- 2021Bladder segmentation based on deep learning approaches: current limitations and lessonscited by 0
- 2022Effect of Prior-based Losses on Segmentation Performance: A Benchmarkcited by 0
- 2023CQnet: convex-geometric interpretation and constraining neural-network trajectoriescited by 0
- 2023Efficient Subclass Segmentation in Medical Imagescited by 0
- 2025DualProtoSeg: Simple and Efficient Design with Text- and Image-Guided Prototype Learning for Weakly Supervised Histopathology Image Segmentationcited by 0
- 2025DualProtoSeg: Simple and Efficient Design with Text- and Image-Guided Prototype Learning for Weakly Supervised Histopathology Image Segmentation11 Dec 2025
- 2025Prompt learning with bounding box constraints for medical image segmentation3 Jul 2025
- 2025Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentation15 Mar 2025
- 2024EP-SAM: Weakly Supervised Histopathology Segmentation via Enhanced Prompt with Segment Anything17 Oct 2024
- 2024Automating MedSAM by Learning Prompts with Weak Few-Shot Supervision30 Sep 2024
- 2024LNQ 2023 challenge: Benchmark of weakly-supervised techniques for mediastinal lymph node quantification19 Aug 2024
- 2024FedLPPA: Learning Personalized Prompt and Aggregation for Federated Weakly-supervised Medical Image Segmentation27 Feb 2024
- 2023BoxCell: Leveraging SAM for Cell Segmentation with Box Supervision29 Nov 2023
- 2023Versatile Medical Image Segmentation Learned from Multi-Source Datasets via Model Self-Disambiguation17 Nov 2023
- 2023Leveraging point annotations in segmentation learning with boundary loss6 Nov 2023
- 2023Efficient Subclass Segmentation in Medical Images1 Jul 2023
- 2023Industrial Anomaly Detection and Localization Using Weakly-Supervised Residual Transformers6 Jun 2023
28 more
- 2023Weakly Supervised Intracranial Hemorrhage Segmentation using Head-Wise Gradient-Infused Self-Attention Maps from a Swin Transformer in Categorical Learning11 Apr 2023
- 2023CQnet: convex-geometric interpretation and constraining neural-network trajectories9 Feb 2023
- 2023Weakly-Supervised 3D Medical Image Segmentation using Geometric Prior and Contrastive Similarity4 Feb 2023
- 2023Weakly Supervised Image Segmentation Beyond Tight Bounding Box Annotations28 Jan 2023
- 2022Greybox XAI: a Neural-Symbolic learning framework to produce interpretable predictions for image classification26 Sep 2022
- 2022A comprehensive survey on recent deep learning-based methods applied to surgical data3 Sep 2022
- 2022PA-Seg: Learning from Point Annotations for 3D Medical Image Segmentation using Contextual Regularization and Cross Knowledge Distillation11 Aug 2022
- 2022Cardiac Adipose Tissue Segmentation via Image-Level Annotations9 Jun 2022
- 2022FedMix: Mixed Supervised Federated Learning for Medical Image Segmentation4 May 2022
- 2022Polar Transformation Based Multiple Instance Learning Assisting Weakly Supervised Image Segmentation With Loose Bounding Box Annotations3 Mar 2022
- 2022Negative Evidence Matters in Interpretable Histology Image Classification7 Jan 2022
- 2022Effect of Prior-based Losses on Segmentation Performance: A Benchmark7 Jan 2022
- 2021Semantic Segmentation In-the-Wild Without Seeing Any Segmentation Examples6 Dec 2021
- 2021One-shot Weakly-Supervised Segmentation in Medical Images21 Nov 2021
- 2021CDRNet: Accurate Cup-to-Disc Ratio Measurement with Tight Bounding Box Supervision in Fundus Photography Using Deep Learning3 Oct 2021
- 2021Bounding Box Tightness Prior for Weakly Supervised Image Segmentation3 Oct 2021
- 2021Segmentation with mixed supervision: Confidence maximization helps knowledge distillation21 Sep 2021
- 2021Self-supervised Multi-scale Consistency for Weakly Supervised Segmentation Learning26 Aug 2021
- 2021Medical image segmentation with imperfect 3D bounding boxes6 Aug 2021
- 2021Source-Free Domain Adaptation for Image Segmentation6 Aug 2021
- 2021Inter Extreme Points Geodesics for End-to-End Weakly Supervised Image Segmentation1 Jul 2021
- 2021Every Annotation Counts: Multi-label Deep Supervision for Medical Image Segmentation27 Apr 2021
- 2021Weakly Supervised Volumetric Segmentation via Self-taught Shape Denoising Model27 Apr 2021
- 2021Weakly supervised segmentation with cross-modality equivariant constraints6 Apr 2021
- 2021Robust Trust Region for Weakly Supervised Segmentation5 Apr 2021
- 2021The surprising impact of mask-head architecture on novel class segmentation1 Apr 2021
- 2021Medical Image Segmentation with Limited Supervision: A Review of Deep Network Models28 Feb 2021
- 2021Bladder segmentation based on deep learning approaches: current limitations and lessons16 Jan 2021
- 2021Source-Free Domain Adaptation for Image Segmentationcited by 45
- 2021Every Annotation Counts: Multi-label Deep Supervision for Medical Image Segmentationcited by 37
- 2021Semantic Segmentation In-the-Wild Without Seeing Any Segmentation Examplescited by 24
- 2022FedMix: Mixed Supervised Federated Learning for Medical Image Segmentationcited by 22
- 2021Medical Image Segmentation with Limited Supervision: A Review of Deep Network Modelscited by 21
- 2021Inter Extreme Points Geodesics for End-to-End Weakly Supervised Image Segmentationcited by 21
- 2021Bounding Box Tightness Prior for Weakly Supervised Image Segmentationcited by 19
- 2021Weakly supervised segmentation with cross-modality equivariant constraintscited by 18
- 2022PA-Seg: Learning from Point Annotations for 3D Medical Image Segmentation using Contextual Regularization and Cross Knowledge Distillationcited by 16
- 2025Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentationcited by 16
- 2021The surprising impact of mask-head architecture on novel class segmentationcited by 13
- 2023Versatile Medical Image Segmentation Learned from Multi-Source Datasets via Model Self-Disambiguationcited by 12
12 most cited of 40 All 40 (JSON)
- 2025DualProtoSeg: Simple and Efficient Design with Text- and Image-Guided Prototype Learning for Weakly Supervised Histopathology Image Segmentation11 Dec 2025
- 2025Prompt learning with bounding box constraints for medical image segmentation3 Jul 2025
- 2025Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentation15 Mar 2025
- 2024EP-SAM: Weakly Supervised Histopathology Segmentation via Enhanced Prompt with Segment Anything17 Oct 2024
- 2024Automating MedSAM by Learning Prompts with Weak Few-Shot Supervision30 Sep 2024
- 2024LNQ 2023 challenge: Benchmark of weakly-supervised techniques for mediastinal lymph node quantification19 Aug 2024
- 2024FedLPPA: Learning Personalized Prompt and Aggregation for Federated Weakly-supervised Medical Image Segmentation27 Feb 2024
- 2023BoxCell: Leveraging SAM for Cell Segmentation with Box Supervision29 Nov 2023
- 2023Versatile Medical Image Segmentation Learned from Multi-Source Datasets via Model Self-Disambiguation17 Nov 2023
- 2023Leveraging point annotations in segmentation learning with boundary loss6 Nov 2023
- 2023Efficient Subclass Segmentation in Medical Images1 Jul 2023
- 2023Industrial Anomaly Detection and Localization Using Weakly-Supervised Residual Transformers6 Jun 2023
12 newest of 40 All 40 (JSON)