Towards Automatic Generation of Shareable Synthetic Clinical Notes Using Neural Language Models
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Abstract (arXiv)
Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed research. De-identification methods attempt to address these concerns but were shown to be susceptible to adversarial attacks. In this work, we focus on the vast amounts of unstructured natural language data stored in clinical notes and propose to automatically generate synthetic clinical notes that are more amenable to sharing using generative models trained on real de-identified records. To evaluate the merit of such notes, we measure both their privacy preservation properties as well as utility in training clinical NLP models. Experiments using neural language models yield notes whose utility is close to that of the real ones in some clinical NLP tasks, yet leave ample room for future improvements.
Key facts. Cited by 20 papers in the map (data through 7 Oct 2026). First posted on arXiv 16 May 2019.
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Citing papers per year: 2021: 4; 2022: 3; 2023: 4; 2024: 3; 2025: 2; 2026: 4.
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- 2021Large Language Models Can Be Strong Differentially Private Learnerscited by 405
- 2023Harnessing large-language models to generate private synthetic textcited by 65
- 2021Selective Differential Privacy for Language Modelingcited by 61
- 2023Publicly Shareable Clinical Large Language Model Built on Synthetic Clinical Notescited by 51
- 2021Neural Natural Language Processing for Unstructured Data in Electronic Health Records: a Reviewcited by 35
- 2022How to keep text private? A systematic review of deep learning methods for privacy-preserving natural language processingcited by 16
- 2023Lightweight Transformers for Clinical Natural Language Processingcited by 15
- 2023Enhancing Small Medical Learners with Privacy-preserving Contextual Promptingcited by 11
- 2021Generating Synthetic Text Data to Evaluate Causal Inference Methodscited by 9
- 2025Understanding the Effects of Domain Finetuning on LLMscited by 4
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applicationscited by 3
- 2022Swing Distillation: A Privacy-Preserving Knowledge Distillation Frameworkcited by 1
8 more
- 2024Zero-shot and Few-shot Generation Strategies for Artificial Clinical Recordscited by 1
- 2026Talking to Yourself: Defying Forgetting in Large Language Modelscited by 1
- 2026PARHAF, a human-authored corpus of clinical reports for fictitious patients in Frenchcited by 1
- 2022The NLP Sandbox: an efficient model-to-data system to enable federated and unbiased evaluation of clinical NLP modelscited by 0
- 2024AspirinSum: an Aspect-based utility-preserved de-identification Summarization frameworkcited by 0
- 2024Generating Completions for Broca's Aphasic Sentences Using Large Language Modelscited by 0
- 2026Clinical Intent Extraction: A FHIR-Aligned Representation and the CIRCA Benchmarkcited by 0
- 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmarkcited by 0
- 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmark24 Sep 2026
- 2026Clinical Intent Extraction: A FHIR-Aligned Representation and the CIRCA Benchmark24 Aug 2026
- 2026PARHAF, a human-authored corpus of clinical reports for fictitious patients in French20 Mar 2026
- 2026Talking to Yourself: Defying Forgetting in Large Language Models23 Jan 2026
- 2025Understanding the Effects of Domain Finetuning on LLMs10 Oct 2025
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applications7 May 2025
- 2024Generating Completions for Broca's Aphasic Sentences Using Large Language Models23 Dec 2024
- 2024AspirinSum: an Aspect-based utility-preserved de-identification Summarization framework20 Jun 2024
- 2024Zero-shot and Few-shot Generation Strategies for Artificial Clinical Records13 Mar 2024
- 2023Publicly Shareable Clinical Large Language Model Built on Synthetic Clinical Notes1 Sep 2023
- 2023Harnessing large-language models to generate private synthetic text2 Jun 2023
- 2023Enhancing Small Medical Learners with Privacy-preserving Contextual Prompting22 May 2023
8 more
- 2023Lightweight Transformers for Clinical Natural Language Processing9 Feb 2023
- 2022Swing Distillation: A Privacy-Preserving Knowledge Distillation Framework16 Dec 2022
- 2022The NLP Sandbox: an efficient model-to-data system to enable federated and unbiased evaluation of clinical NLP models28 Jun 2022
- 2022How to keep text private? A systematic review of deep learning methods for privacy-preserving natural language processing20 May 2022
- 2021Large Language Models Can Be Strong Differentially Private Learners12 Oct 2021
- 2021Selective Differential Privacy for Language Modeling30 Aug 2021
- 2021Neural Natural Language Processing for Unstructured Data in Electronic Health Records: a Review7 Jul 2021
- 2021Generating Synthetic Text Data to Evaluate Causal Inference Methods10 Feb 2021
- 2021Large Language Models Can Be Strong Differentially Private Learnerscited by 405
- 2023Harnessing large-language models to generate private synthetic textcited by 65
- 2021Selective Differential Privacy for Language Modelingcited by 61
- 2023Publicly Shareable Clinical Large Language Model Built on Synthetic Clinical Notescited by 51
- 2021Neural Natural Language Processing for Unstructured Data in Electronic Health Records: a Reviewcited by 35
- 2022How to keep text private? A systematic review of deep learning methods for privacy-preserving natural language processingcited by 16
- 2023Lightweight Transformers for Clinical Natural Language Processingcited by 15
- 2023Enhancing Small Medical Learners with Privacy-preserving Contextual Promptingcited by 11
- 2021Generating Synthetic Text Data to Evaluate Causal Inference Methodscited by 9
- 2025Understanding the Effects of Domain Finetuning on LLMscited by 4
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applicationscited by 3
- 2022Swing Distillation: A Privacy-Preserving Knowledge Distillation Frameworkcited by 1
12 most cited of 19 All 19 (JSON)
- 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmark24 Sep 2026
- 2026Clinical Intent Extraction: A FHIR-Aligned Representation and the CIRCA Benchmark24 Aug 2026
- 2026PARHAF, a human-authored corpus of clinical reports for fictitious patients in French20 Mar 2026
- 2025Understanding the Effects of Domain Finetuning on LLMs10 Oct 2025
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applications7 May 2025
- 2024Generating Completions for Broca's Aphasic Sentences Using Large Language Models23 Dec 2024
- 2024AspirinSum: an Aspect-based utility-preserved de-identification Summarization framework20 Jun 2024
- 2024Zero-shot and Few-shot Generation Strategies for Artificial Clinical Records13 Mar 2024
- 2023Publicly Shareable Clinical Large Language Model Built on Synthetic Clinical Notes1 Sep 2023
- 2023Harnessing large-language models to generate private synthetic text2 Jun 2023
- 2023Enhancing Small Medical Learners with Privacy-preserving Contextual Prompting22 May 2023
- 2023Lightweight Transformers for Clinical Natural Language Processing9 Feb 2023
12 newest of 19 All 19 (JSON)