Enhancing Small Medical Learners with Privacy-preserving Contextual Prompting
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Abstract (arXiv)
Large language models (LLMs) demonstrate remarkable medical expertise, but data privacy concerns impede their direct use in healthcare environments. Although offering improved data privacy protection, domain-specific small language models (SLMs) often underperform LLMs, emphasizing the need for methods that reduce this performance gap while alleviating privacy concerns. In this paper, we present a simple yet effective method that harnesses LLMs' medical proficiency to boost SLM performance in medical tasks under privacy-restricted scenarios. Specifically, we mitigate patient privacy issues by extracting keywords from medical data and prompting the LLM to generate a medical knowledge-intensive context by simulating clinicians' thought processes. This context serves as additional input for SLMs, augmenting their decision-making capabilities. Our method significantly enhances performance in both few-shot and full training settings across three medical knowledge-intensive tasks, achieving up to a 22.57% increase in absolute accuracy compared to SLM fine-tuning without context, and sets new state-of-the-art results in two medical tasks within privacy-restricted scenarios. Further out-of-domain testing and experiments in two general domain datasets showcase its generalizability and broad applicability. Our code can be found at https://github.com/XZhang97666/PrivacyBoost-SLM.
Key facts. Cited by 11 papers in the map (data through 14 Oct 2026). Builds on 52 of its 80 references that are in the map. First posted on arXiv 22 May 2023.
Builds on
52 of 80 references.
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Citing papers per year: 2023: 3; 2024: 3; 2025: 3; 2026: 2.
11 papers.
- 2023AlpaCare:Instruction-tuned Large Language Models for Medical Applicationcited by 90
- 2024Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Datacited by 66
- 2024Unveiling the Impact of Coding Data Instruction Fine-Tuning on Large Language Models Reasoningcited by 31
- 2023Instruction-following Evaluation through Verbalizer Manipulationcited by 30
- 2023PrivacyMind: Large Language Models Can Be Contextual Privacy Protection Learnerscited by 14
- 2025LLM Sensitivity Evaluation Framework for Clinical Diagnosiscited by 7
- 2025A Survey on Collaborating Small and Large Language Models for Performance, Cost-effectiveness, Cloud-edge Privacy, and Trustworthinesscited by 7
- 2024Retrieval Augmented Thought Process for Private Data Handling in Healthcarecited by 5
- 2025FedCoT: Communication-Efficient Federated Reasoning Enhancement for Large Language Modelscited by 1
- 2026Continual Pretraining on Encrypted Synthetic Data for Privacy-Preserving LLMscited by 0
- 2026Applying Language Models in Clinical Medicine: Recent Trends and Perspectivescited by 0
- 2026Applying Language Models in Clinical Medicine: Recent Trends and Perspectives28 Sep 2026
- 2026Continual Pretraining on Encrypted Synthetic Data for Privacy-Preserving LLMs9 Jan 2026
- 2025A Survey on Collaborating Small and Large Language Models for Performance, Cost-effectiveness, Cloud-edge Privacy, and Trustworthiness14 Oct 2025
- 2025FedCoT: Communication-Efficient Federated Reasoning Enhancement for Large Language Models7 Aug 2025
- 2025LLM Sensitivity Evaluation Framework for Clinical Diagnosis18 Apr 2025
- 2024Unveiling the Impact of Coding Data Instruction Fine-Tuning on Large Language Models Reasoning30 May 2024
- 2024Retrieval Augmented Thought Process for Private Data Handling in Healthcare12 Feb 2024
- 2024Health-LLM: Large Language Models for Health Prediction via Wearable Sensor Data12 Jan 2024
- 2023AlpaCare:Instruction-tuned Large Language Models for Medical Application23 Oct 2023
- 2023PrivacyMind: Large Language Models Can Be Contextual Privacy Protection Learners3 Oct 2023
- 2023Instruction-following Evaluation through Verbalizer Manipulation20 Jul 2023