A confounding bridge approach for double negative control inference on causal effects
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Abstract (arXiv)
Unmeasured confounding is a key challenge for causal inference. In this paper, we establish a framework for unmeasured confounding adjustment with negative control variables. A negative control outcome is associated with the confounder but not causally affected by the exposure in view, and a negative control exposure is correlated with the primary exposure or the confounder but does not causally affect the outcome of interest. We introduce an outcome confounding bridge function that depicts the relationship between the confounding effects on the primary outcome and the negative control outcome, and we incorporate a negative control exposure to identify the bridge function and the average causal effect. We also consider the extension to the positive control setting by allowing for nonzero causal effect of the primary exposure on the control outcome. We illustrate our approach with simulations and apply it to a study about the short-term effect of air pollution on mortality. Although a standard analysis shows a significant acute effect of PM2.5 on mortality, our analysis indicates that this effect may be confounded, and after double negative control adjustment, the effect is attenuated toward zero.
Key facts. Cited by 36 papers in the map (data through 7 Oct 2026). First posted on arXiv 15 Aug 2018.
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Citing papers per year: 2021: 6; 2022: 8; 2023: 8; 2024: 7; 2025: 3; 2026: 4.
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- 2021Proximal Reinforcement Learning: Efficient Off-Policy Evaluation in Partially Observed Markov Decision Processescited by 40
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- 2023Assumption-lean falsification tests of rate double-robustness of double-machine-learning estimatorscited by 2
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- 2023Contagion Effect Estimation Using Proximal Embeddingscited by 1
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- 2025Coupling Generative Modeling and an Autoencoder with the Causal Bridgecited by 0
- 2026Adaptive Estimation and Inference in Conditional Moment Models via the Discrepancy Principlecited by 0
- 2026Cross-fitted Proximal Learning for Model-Based Reinforcement Learningcited by 0
- 2026Decision-Aware Proximal Bridge Learning for Optimal Treatment Selectioncited by 0
- 2026Spatiotemporal Proximal Causal Inference under Hidden Confounding and Interferencecited by 0
- 2026Spatiotemporal Proximal Causal Inference under Hidden Confounding and Interference2 Aug 2026
- 2026Decision-Aware Proximal Bridge Learning for Optimal Treatment Selection16 May 2026
- 2026Cross-fitted Proximal Learning for Model-Based Reinforcement Learning6 Apr 2026
- 2026Adaptive Estimation and Inference in Conditional Moment Models via the Discrepancy Principle2 Mar 2026
- 2025Coupling Generative Modeling and an Autoencoder with the Causal Bridge29 Sep 2025
- 2025Sequential Treatment Effect Estimation with Unmeasured Confounders14 May 2025
- 2025Learning Exposure Mapping Functions for Inferring Heterogeneous Peer Effects3 Mar 2025
- 2024Assumption-Lean Post-Integrated Inference with Surrogate Control Outcomes7 Oct 2024
- 2024Causal Inference with Complex Treatments: A Survey19 Jul 2024
- 2024Spillover Detection for Donor Selection in Synthetic Control Models17 Jun 2024
- 2024Synthetic Potential Outcomes and Causal Mixture Identifiability29 May 2024
- 2024Automating the Selection of Proxy Variables of Unmeasured Confounders25 May 2024
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- 2024Predictive Performance Comparison of Decision Policies Under Confounding1 Apr 2024
- 2024Regularized DeepIV with Model Selection7 Mar 2024
- 2023AI in Pharma for Personalized Sequential Decision-Making: Methods, Applications and Opportunities30 Nov 2023
- 2023Doubly Robust Proximal Causal Learning for Continuous Treatments22 Sep 2023
- 2023Assumption-lean falsification tests of rate double-robustness of double-machine-learning estimators18 Jun 2023
- 2023Contagion Effect Estimation Using Proximal Embeddings4 Jun 2023
- 2023A Policy Gradient Method for Confounded POMDPs26 May 2023
- 2023Partial Identification of Causal Effects Using Proxy Variables10 Apr 2023
- 2023A Unified Framework of Policy Learning for Contextual Bandit with Confounding Bias and Missing Observations20 Mar 2023
- 2023Debiasing Recommendation by Learning Identifiable Latent Confounders10 Feb 2023
- 2022Optimal Treatment Regimes for Proximal Causal Learning19 Dec 2022
- 2022Blessing from Human-AI Interaction: Super Reinforcement Learning in Confounded Environments29 Sep 2022
- 2022Off-Policy Evaluation for Episodic Partially Observable Markov Decision Processes under Non-Parametric Models21 Sep 2022
- 2022Inference on Strongly Identified Functionals of Weakly Identified Functions17 Aug 2022
- 2022Future-Dependent Value-Based Off-Policy Evaluation in POMDPs26 Jul 2022
- 2022Provably Efficient Reinforcement Learning in Partially Observable Dynamical Systems24 Jun 2022
- 2022Pessimism in the Face of Confounders: Provably Efficient Offline Reinforcement Learning in Partially Observable Markov Decision Processes26 May 2022
- 2022Long-term Causal Inference Under Persistent Confounding via Data Combination15 Feb 2022
- 2021Proximal Reinforcement Learning: Efficient Off-Policy Evaluation in Partially Observed Markov Decision Processes28 Oct 2021
- 2021Many Proxy Controls8 Oct 2021
- 2021The Proximal ID Algorithm15 Aug 2021
- 2021Deep Proxy Causal Learning and its Application to Confounded Bandit Policy Evaluation7 Jun 2021
- 2021Proximal Learning for Individualized Treatment Regimes Under Unmeasured Confounding3 May 2021
- 2021Minimax Kernel Machine Learning for a Class of Doubly Robust Functionals with Application to Proximal Causal Inference7 Apr 2021
- 2021Deep Proxy Causal Learning and its Application to Confounded Bandit Policy Evaluationcited by 39
- 2022Provably Efficient Reinforcement Learning in Partially Observable Dynamical Systemscited by 35
- 2022Long-term Causal Inference Under Persistent Confounding via Data Combinationcited by 27
- 2021Proximal Learning for Individualized Treatment Regimes Under Unmeasured Confoundingcited by 21
- 2021Minimax Kernel Machine Learning for a Class of Doubly Robust Functionals with Application to Proximal Causal Inferencecited by 20
- 2022Future-Dependent Value-Based Off-Policy Evaluation in POMDPscited by 20
- 2022Off-Policy Evaluation for Episodic Partially Observable Markov Decision Processes under Non-Parametric Modelscited by 18
- 2022Inference on Strongly Identified Functionals of Weakly Identified Functionscited by 12
- 2021The Proximal ID Algorithmcited by 11
- 2023Debiasing Recommendation by Learning Identifiable Latent Confounderscited by 7
- 2023Partial Identification of Causal Effects Using Proxy Variablescited by 7
- 2023A Policy Gradient Method for Confounded POMDPscited by 6
12 most cited of 34 All 34 (JSON)
- 2026Spatiotemporal Proximal Causal Inference under Hidden Confounding and Interference2 Aug 2026
- 2026Decision-Aware Proximal Bridge Learning for Optimal Treatment Selection16 May 2026
- 2026Cross-fitted Proximal Learning for Model-Based Reinforcement Learning6 Apr 2026
- 2026Adaptive Estimation and Inference in Conditional Moment Models via the Discrepancy Principle2 Mar 2026
- 2025Coupling Generative Modeling and an Autoencoder with the Causal Bridge29 Sep 2025
- 2025Sequential Treatment Effect Estimation with Unmeasured Confounders14 May 2025
- 2025Learning Exposure Mapping Functions for Inferring Heterogeneous Peer Effects3 Mar 2025
- 2024Assumption-Lean Post-Integrated Inference with Surrogate Control Outcomes7 Oct 2024
- 2024Causal Inference with Complex Treatments: A Survey19 Jul 2024
- 2024Spillover Detection for Donor Selection in Synthetic Control Models17 Jun 2024
- 2024Synthetic Potential Outcomes and Causal Mixture Identifiability29 May 2024
- 2024Automating the Selection of Proxy Variables of Unmeasured Confounders25 May 2024
12 newest of 34 All 34 (JSON)