mlsanityData to 14 Oct 2026

Constrained-CNN losses for weakly supervised segmentation

arXiv 1805.04628 ↗First posted 12 May 2018cs.CVcited by 62

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Abstract (arXiv)

Weakly-supervised learning based on, e.g., partially labelled images or image-tags, is currently attracting significant attention in CNN segmentation as it can mitigate the need for full and laborious pixel/voxel annotations. Enforcing high-order (global) inequality constraints on the network output (for instance, to constrain the size of the target region) can leverage unlabeled data, guiding the training process with domain-specific knowledge. Inequality constraints are very flexible because they do not assume exact prior knowledge. However, constrained Lagrangian dual optimization has been largely avoided in deep networks, mainly for computational tractability reasons. To the best of our knowledge, the method of [Pathak et al., 2015] is the only prior work that addresses deep CNNs with linear constraints in weakly supervised segmentation. It uses the constraints to synthesize fully-labeled training masks (proposals) from weak labels, mimicking full supervision and facilitating dual optimization. We propose to introduce a differentiable penalty, which enforces inequality constraints directly in the loss function, avoiding expensive Lagrangian dual iterates and proposal generation. From constrained-optimization perspective, our simple penalty-based approach is not optimal as there is no guarantee that the constraints are satisfied. However, surprisingly, it yields substantially better results than the Lagrangian-based constrained CNNs in [Pathak et al., 2015], while reducing the computational demand for training. By annotating only a small fraction of the pixels, the proposed approach can reach a level of segmentation performance that is comparable to full supervision on three separate tasks. While our experiments focused on basic linear constraints such as the target-region size and image tags, our framework can be easily extended to other non-linear constraints.

Key facts. Cited by 62 papers in the map (data through 14 Oct 2026). First posted on arXiv 12 May 2018.

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Citing papers per year: 2021: 19; 2022: 16; 2023: 11; 2024: 8; 2025: 4; 2026: 4.

62 papers.

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  1. 2021Source-Free Domain Adaptation for Image Segmentationcited by 45
  2. 2024Robust Calibration of Large Vision-Language Adapterscited by 28
  3. 2024EAGLE: Eigen Aggregation Learning for Object-Centric Unsupervised Semantic Segmentationcited by 27
  4. 2021Medical Image Segmentation with Limited Supervision: A Review of Deep Network Modelscited by 22
  5. 2021Inter Extreme Points Geodesics for End-to-End Weakly Supervised Image Segmentationcited by 21
  6. 2022Constrained unsupervised anomaly segmentationcited by 19
  7. 2022Test-Time Adaptation with Shape Moments for Image Segmentationcited by 19
  8. 2022Local Spatiotemporal Representation Learning for Longitudinally-consistent Neuroimage Analysiscited by 19
  9. 2021Weakly supervised segmentation with cross-modality equivariant constraintscited by 18
  10. 2022PA-Seg: Learning from Point Annotations for 3D Medical Image Segmentation using Contextual Regularization and Cross Knowledge Distillationcited by 17
  11. 2025Prototype-Based Image Prompting for Weakly Supervised Histopathological Image Segmentationcited by 17
  12. 2022Scribble2D5: Weakly-Supervised Volumetric Image Segmentation via Scribble Annotationscited by 15
38 more
  1. 2023Weakly supervised segmentation with point annotations for histopathology images via contrast-based variational modelcited by 13
  2. 2022Non-Iterative Scribble-Supervised Learning with Pacing Pseudo-Masks for Medical Image Segmentationcited by 9
  3. 2022Anatomy-guided domain adaptation for 3D in-bed human pose estimationcited by 9
  4. 2023Weakly-Supervised 3D Medical Image Segmentation using Geometric Prior and Contrastive Similaritycited by 9
  5. 2022Negative Evidence Matters in Interpretable Histology Image Classificationcited by 8
  6. 2021Recent Advances in Fibrosis and Scar Segmentation from Cardiac MRI: A State-of-the-Art Review and Future Perspectivescited by 7
  7. 2021Re-using Adversarial Mask Discriminators for Test-time Training under Distribution Shiftscited by 7
  8. 2021Segmentation with mixed supervision: Confidence maximization helps knowledge distillationcited by 6
  9. 2021Beyond pixel-wise supervision for segmentation: A few global shape descriptors might be surprisingly good!cited by 5
  10. 2021Self-supervised Multi-scale Consistency for Weakly Supervised Segmentation Learningcited by 4
  11. 2021Stop Throwing Away Discriminators! Re-using Adversaries for Test-Time Trainingcited by 4
  12. 2021Looking at the whole picture: constrained unsupervised anomaly segmentationcited by 4
  13. 2022Annotation by Clicks: A Point-Supervised Contrastive Variance Method for Medical Semantic Segmentationcited by 4
  14. 2024Tackling Ambiguity from Perspective of Uncertainty Inference and Affinity Diversification for Weakly Supervised Semantic Segmentationcited by 4
  15. 2024Beyond Pixel-Wise Supervision for Medical Image Segmentation: From Traditional Models to Foundation Modelscited by 4
  16. 2023Prompting classes: Exploring the Power of Prompt Class Learning in Weakly Supervised Semantic Segmentationcited by 3
  17. 2023Boundary-RL: Reinforcement Learning for Weakly-Supervised Prostate Segmentation in TRUS Imagescited by 3
  18. 2023Leveraging Anatomical Constraints with Uncertainty for Pneumothorax Segmentationcited by 3
  19. 2021Weakly Supervised Volumetric Segmentation via Self-taught Shape Denoising Modelcited by 2
  20. 2022On the pitfalls of entropy-based uncertainty for multi-class semi-supervised segmentationcited by 2
  21. 2022Learning to segment prostate cancer by aggressiveness from scribbles in bi-parametric MRIcited by 2
  22. 2022Information Gain Sampling for Active Learning in Medical Image Classificationcited by 2
  23. 2023Leveraging point annotations in segmentation learning with boundary losscited by 2
  24. 2026SnareNet: Flexible Repair Layers for Neural Networks with Hard Constraintscited by 2
  25. 2021Atlas-aware ConvNetfor Accurate yet Robust Anatomical Segmentationcited by 1
  26. 2021One-shot Weakly-Supervised Segmentation in Medical Imagescited by 1
  27. 2022Towards Positive Jacobian: Learn to Postprocess Diffeomorphic Image Registration with Matrix Exponentialcited by 1
  28. 2023Semantic Segmentation by Semantic Proportionscited by 1
  29. 2023Volumetric Medical Image Segmentation via Scribble Annotations and Shape Priorscited by 1
  30. 2024Clinical Domain Knowledge-Derived Template Improves Post Hoc AI Explanations in Pneumothorax Classificationcited by 1
  31. 2025Implicit Bias in Matrix Factorization and its Explicit Realization in a New Architecturecited by 1
  32. 2025MedCL: Learning Consistent Anatomy Distribution for Scribble-supervised Medical Image Segmentationcited by 1
  33. 2025Solving Scene Understanding for Autonomous Navigation in Unstructured Environmentscited by 1
  34. 2021Bladder segmentation based on deep learning approaches: current limitations and lessonscited by 0
  35. 2021Expectation-Maximization Regularized Deep Learning for Weakly Supervised Tumor Segmentation for Glioblastomacited by 0
  36. 2021Stateless actor-critic for instance segmentation with high-level priorscited by 0
  37. 2021Context-aware virtual adversarial training for anatomically-plausible segmentationcited by 0
  38. 2021Automatic cerebral hemisphere segmentation in rat MRI with lesions via attention-based convolutional neural networkscited by 0

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