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Can LLMs Follow Medical Expert Logic? A Benchmark for Hierarchical Logical Consistency in Risk-of-Bias Assessment

arXiv 2609.11185 ↗First posted 10 Sep 2026cs.AIcited by 0

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Abstract (arXiv)

Evidence-based medicine demands strict logical consistency, yet current evaluations of large language models (LLMs) prioritize superficial label matching over genuine reasoning. We introduce LogiMed-RoB, a benchmark grounded in Cochrane Risk of Bias (RoB) 2.0 expert logic, comprising 860 randomized controlled trials (RCTs) and 14,820 queries. It evaluates models under the Hierarchical Logical Consistency (HLC) framework across four dimensions: Atomic Consistency, Domain Consistency, Aggregation Consistency, and Evidential Faithfulness. Experiments on 10 state-of-the-art LLMs reveal a catastrophic Error Compounding Effect: despite the top model reaching 98.88% Atomic Consistency, its end-to-end consistency collapses to 45.13%, with several open-weight architectures plummeting to nearly 0%. We further uncover a systematic evidence-reasoning gap: even when models retrieve high-quality evidence, they fail to deduce correct outcomes in 18.63-40.05% of cases, while Blind Guess Rates reach 48.28%. LogiMed-RoB demonstrates that high outcome accuracy can conceal critical reasoning flaws, underscoring the necessity of white-box logical verification for clinical deployment.

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References · 16

  1. 2020Shortcut Learning in Deep Neural Networkscited by 1,969
  2. 2022Large Language Models Encode Clinical Knowledgecited by 1,830
  3. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
  4. 2023Language Models Don't Always Say What They Think: Unfaithful Explanations in Chain-of-Thought Promptingcited by 1,122
  5. 2023Capabilities of GPT-4 on Medical Challenge Problemscited by 638
  6. 2023Faith and Fate: Limits of Transformers on Compositionalitycited by 503
  7. 2023Logic-LM: Empowering Large Language Models with Symbolic Solvers for Faithful Logical Reasoningcited by 391
  8. 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 224
  9. 2020The Next Decade in AI: Four Steps Towards Robust Artificial Intelligencecited by 195
  10. 2023LINC: A Neurosymbolic Approach for Logical Reasoning by Combining Language Models with First-Order Logic Proverscited by 168
  11. 2018A Corpus with Multi-Level Annotations of Patients, Interventions and Outcomes to Support Language Processing for Medical Literaturecited by 79
  12. 2025Baichuan-M2: Scaling Medical Capability with Large Verifier Systemcited by 59
4 more
  1. 2025From Scores to Steps: Diagnosing and Improving LLM Performance in Evidence-Based Medical Calculationscited by 11
  2. 2024Measuring Risk of Bias in Biomedical Reports: The RoBBR Benchmarkcited by 4
  3. 2025ROBoto2: An Interactive System and Dataset for LLM-assisted Clinical Trial Risk of Bias Assessmentcited by 3
  4. 2025Automated Risk-of-Bias Assessment of Randomized Controlled Trials: A First Look at a GEPA-trained Programmatic Prompting Frameworkcited by 3

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