RadPRISM: Schema-stratified radiology-report supervision for concept-disentangled image representations and visual grounding
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
Vision-language pretraining learns rich medical image representations from radiology reports, but previous model variants commonly operate within a single shared embedding space, so concept-level structure and interpretability must be recovered post hoc, limiting model transparency and, hence, clinical utility. We introduce RadPRISM, which makes a clinician-defined radiology schema a designated stratification axis: an on-premise large language model extracts per-concept text spans from free-text reports, and each clinical concept is aligned in its own dedicated visual subspace, turning concept stratification into direct, top-level alignment supervision. Instantiated on chest radiographs with a 19-concept schema over 203,602 examinations from an internal multi-year archive, RadPRISM improved internal dataset zero-shot classification from 0.717 (95% CI, 0.710-0.723) to 0.868 (95% CI, 0.863-0.872) macro AUROC over a matched global-alignment baseline, performed on par with the purpose-built CARZero reference in external zero-shot classification while substantially outperforming it (up to 4.3-fold) in pointing-game visual grounding. In addition, a radiologist reader study demonstrated concept-stratified retrieval ability (0.78 macro retrieval correctness rate within rank 3), surfacing disentangled descriptive findings that report-level retrieval and fixed-label vocabularies cannot express. RadPRISM yields discriminative, spatially faithful, natively concept-stratified representations shaped by and transparently inspectable by clinicians.
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 20 of its 46 references that are in the map. First posted on arXiv 31 Jul 2026.
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20 of 46 references.
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- 2025Anatomy-VLM: A Fine-grained Vision-Language Model for Medical Interpretation11 Nov
- 2025XBench: A Comprehensive Benchmark for Visual-Language Explanations in Chest Radiography22 Oct
Other references · 18
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6 more
- 2021VALSE: A Task-Independent Benchmark for Vision and Language Models Centered on Linguistic Phenomenacited by 134
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- 2024CARZero: Cross-Attention Alignment for Radiology Zero-Shot Classificationcited by 40
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- 2026Harrison.Rad 1.5 Technical Report: A radiology foundation model that can draft reports from images, priors and clinical context
- 2026GreenRFM: Learning a resource-efficient radiology vision-language foundation model via supervision-centric pre-training
- 2026Graph-Supervised Hierarchical Clinical Alignment for Radiology Report Generation with Large Language Models
- 2026AlphaRAD: Grounded Zero-Shot Classification in Chest Radiology via α-Corrected Binary Cross Entropy and Factorized Latent Supervision
- 2025A Reality Check of Vision-Language Pre-training in Radiology: Have We Progressed Using Text?
- 2026RadAnnotate: Large Language Models for Efficient and Reliable Radiology Report Annotation